Dynamics of growth and death within a Salmonella typhimurium population during infection of macrophages

Canadian Journal of Microbiology

Volumn 43, Issue 1, 1997, Pages 29-34

  Buchmeier, Nancy A ^a   Libby, Stephen J ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

macrophage; purD; purine auxotroph; Salmonella

Indexed keywords

ANIMAL CELL; ARTICLE; BACTERIAL GROWTH; CELL COUNT; DEATH; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM;

EID: 0031057032     PISSN: 00084166     EISSN: None     Source Type: Journal    
DOI: 10.1139/m97-005     Document Type: Article

References (16)

1. Abshire, K., and Neidhardt, F. 1993. Growth paradox of Salmonella typhimurium within host macrophages. J. Bacteriol. 175: 3744-3748.
2. Alpuche-Aranda, C., Berthiaume, E., Mock, B., Swanson, J., and Miller, S. 1995. Spacious phagosome formation within mouse macrophages correlates with Salmonella serotype pathogenicity and host specificity. Infect. Immun. 63: 4456-4462.
3. Baumler, A.J., Kusters, J., Stojiljkovic, I., and Heffron, F. 1994. Salmonella typhimurium loci involved in survival within macrophages. Infect. Immun. 62: 1623-1630.
4. Buchmeier, N.A., and Heffron, F. 1989. Intracellular survival of wild-type Salmonella typhimurium and macrophage-sensitive mutants in diverse populations of macrophages. Infect. Immun. 57: 1-7.
5. Buchmeier, N.A., Lipps, C.J., So, M., and Heffron, F. 1993. Recombination-deficient mutants of Salmonella typhimurium are avirulent and sensitive to the oxidative burst of macrophages. Mol. Microbiol. 7: 933-936.
6. Buchmeier, N.A., Libby, S.J., Xu, Y., Loewen, P.C., Switala, J., Guiney, D.G., and Fang, F.C. 1995. DNA repair is more important than catalase for Salmonella virulence in mice. J. Clin. Invest. 95: 1047-1053.
7. Chopra, A., Peterson, J., and Prasad, R. 1991. Nucleotide sequence analysis of pur and purD genes from Salmonella typhimurium. Biochim. Biophys. Acta, 1090: 351-354.
8. de Chastellier, C. and Berche, P. 1994. Fate of Listeria monocytogenes in murine macrophages: evidence for simultaneous killing and survival of intracellular bacteria. Infect. Immun. 62: 543-553.
9. DeGroote, M., Granger, D., Xu, Y., Campbell, G., Prince, R., and Fang, F. 1995. Genetic and redox determinants of nitric oxide cytotoxicity in a Salmonella typhimurium model. Proc. Natl. Acad. Sci. U.S.A. 92: 6399-6403.
10. Fields, P.I., Swanson, R.V., Haidaris, C.G., and Heffron, F. 1986. Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent. Proc. Natl. Acad. Sci. U.S.A. 83: 5189-5193.
11. Fields, P.I., Groisman, E.A., and Heffron, F. 1989. A Salmonella locus that controls resistance to microbicidal proteins from phagocytic cells. Science (Washington, D.C.), 243: 1059-1062.
12. Leung, K.Y., and Finlay, B.B. 1991. Intracellular replication is essential for the virulence of Salmonella typhimurium. Proc. Natl. Acad. Sci. U.S.A. 88: 11470-11474.
13. Miller, S.I., and Mekalanos, J.J. 1990. Constitutive expression of the PhoP regulon attenuates Salmonella virulence and survival within macrophages. J. Bacteriol. 172: 2485-2490.
14. Papp-Szabo, E., Firtel, M., and Josephy, P.D. 1994. Comparison of the sensitivities of Salmonella typhimurium oxyR and katG mutants to killing by human neutrophils. Infect. Immun. 62: 2662-2668.
15. Raybourne, R., and Bunning, V. 1994. Bacterium-host cell interactions at the cellular level: fluorescent labeling and analysis of short-term bacterium-phagocyte interaction by flow cytometry. Infect. Immun. 62: 665-672.
16. Tsolis, R., Baumler, A., and Heffron, F. 1995. Role of Salmonella typhimurium Mn-superoxide dismutase (SodA) in protection against early killing by J774 macrophages. Infect. Immun. 63: 1739-1744.