Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist

European Journal of Pharmacology

Volumn 323, Issue 2-3, 1997, Pages 181-192

  Baron, Bruce M ^a   Harrison, Boyd L ^a   Kehne, John H ^a   Schmidt, Christopher J ^a   Van Giersbergen, Paul L M ^a   White, H Steven ^b   Siegel, Barry W ^a   Senyah, Yaw ^a   McCloskey, Timothy C ^a   Fadayel, Gina M ^a   Taylor, Vicki L ^a   Murawsky, Michael K ^a   Nyce, Phillip ^a,c   Salituro, Francesco G ^a,c  

^a SANOFI   (France)

^b UNIVERSITY OF UTAH   (United States)

^c VERTEX PHARMACEUTICALS   (United States)

Author keywords

Anticonvulsant; Anxiolytic; Dopamine; Excitatory amino acid; Psychosis; Sensory processing

Indexed keywords

3 (2 CARBOXY 2 PHENYLETHENYL) 4,6 DICHLORO 1H INDOLE 2 CARBOXYLIC ACID; CYCLIC GMP; DIZOCILPINE; DOPAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN MEMBRANE; BRAIN SLICE; CHO CELL; CONTROLLED STUDY; CONVULSION; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; MUSCLE RELAXATION; NONHUMAN; PRIORITY JOURNAL; RAT; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; ANTICONVULSANTS; CALCIUM CHANNELS; CELLS, CULTURED; CEREBELLUM; CYCLIC GMP; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; INDOLES; LIGANDS; MALE; MICE; MICE, INBRED DBA; MOTOR ACTIVITY; N-METHYLASPARTATE; PHENCYCLIDINE; RATS; RATS, INBRED F344; RATS, WISTAR; RECEPTORS, GLYCINE; RECEPTORS, N-METHYL-D-ASPARTATE; SODIUM CHANNELS;

EID: 0030999917     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)00045-9     Document Type: Article

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