Thyroglobulin monoclonal antibody cross-reacting with thyroperoxidase induces in syngeneic mice anti-idiotypic monoclonal antibodies with dual autoantigen binding properties. The intertope hypothesis

European Journal of Immunology

Volumn 29, Issue 5, 1999, Pages 1626-1634

  Duthoit, Christine ^a   Estienne, Valérie ^a   Durand Gorde, Josée Martine ^a   Carayon, Pierre ^a   Ruf, Jean ^a  

^a INSERM   (France)

Author keywords

Anti idiotypic antibody; Autoantibody; Autoimmunity; Thyroid

Indexed keywords

CROSS REACTING ANTIBODY; MONOCLONAL ANTIBODY; THYROGLOBULIN ANTIBODY; THYROID ANTIBODY; THYROID PEROXIDASE;

ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNITY; CROSS REACTION; HASHIMOTO DISEASE; IMMUNIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY;

EID: 0032927432     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199905)29:05<1626::AID-IMMU1626>3.0.CO;2-7     Document Type: Article

References (46)

1. Lissitzky, S., Torresani, J., Carayon, P. and Amr, S., Physiology of the thyroid. In DeGroot, L. J. (Ed.) Endocrinology, 2nd Edn., Vol. 1. Saunders, Philadelphia 1989, pp 512-540.
2. Weetman, A. P. and McGregor, A. M., Autoimmune thyroid disease: further development in our understanding. Endocr. Rev. 1994. 15: 788-830.
3. Ruf, J., Ferrand, M., Durand-Gorde, J.-M. and Carayon, P., Immunopurification and characterization of thyroid autoantibodies with dual specificity for thyroglobulin and thyroperoxidase. Autoimmunity 1992. 11: 179-188.
4. Henry, M., Zanelli, E. and Malthiery, Y., Anti-human thyroid peroxidase and anti-human thyroglobulin antibodies present no cross-reactivity on recombinant peptides. Clin. Exp. Immunol. 1991. 86: 478-482.
5. Ruf, J., Ferrand, M., Durand-Gorde, J.-M., Lejeune, P. J., Mallet, B., Marriq, C. and Carayon, P., Thyroglobulin-peroxidase antibodies, a new class of thyroid antibodies with dual specificity for thyroglobulin and thyroperoxidase. In Nagataki, S., Mori, T. and Torizuka, K. (Eds.) 80 years of Hashimoto Disease. Elsevier, Amsterdam 1993, pp 393-398.
6. Ruf, J. and Carayon, P., The molecular recognition theory applied to bispecific antibodies. Nature Med. 1995. 1: 1222.
7. Ruf, J., Ferrand, M., Durand-Gorde, J.-M. and Carayon, P., Autoantibodies and monoclonal antibodies directed to an immunodominant antigenic region of thyroglobulin interact with thyroperoxidase through an interspecies idiotype. Autoimmunity 1994. 19: 55-62.
8. Villa, M., Durand-Gorde, J.-M., Carayon, P. and Ruf, J., Idiotypic study of a bispecific thyroglobulin and thyroperoxidase monoclonal antibody. J. Autoimmun. 1996. 9: 653-660.
9. Coutinho, A., The network theory: 21 years later. Scand. J. Immunol. 1995. 42: 3-8.
10. Shoenfeld, Y., Idiotypic induction of autoimmunity: a new aspect of the idiotypic network. FASEB J. 1994. 8: 1296-1301.
11. Tomer, Y., Gilburd, B., Sack, J., Davies, T. F., Meshorer, A., Lynne Burek, C., Rose, N. R. and Shoenfeld, Y., Induction of thyroid autoantibodies in naive mice by idiotypic manipulation. Clin. Immunol. Immunopathol. 1996. 78: 180-187.
12. Wadeleux, P., Winand-Devigne, J., Ruf, J., Carayon, P. and Winand, R., Cytotoxic assay of circulating thyroid peroxidase antibodies. Autoimmunity 1989. 4: 247-254.
13. Rodien, P., Madec, A. M., Ruf, J., Rajas, F., Bornet, H., Carayon, P. and Orgiazzi, J., Antibody-dependent cell-mediated cytotoxicity in autoimmune thyroid disease: relationship to antithyroperoxidase antibodies. J. Clin. Endocrinol. Metab. 1996. 81: 2595-2600.
14. Kohno, Y., Hiyama, Y., Shimojo, N., Niimi, H., Nakajima, H. and Hosoya, T., Autoantibodies to thyroid peroxidase in patients with chronic thyroiditis: effect of antibody binding on enzyme activities. Clin. Exp. Immunol. 1986. 65: 534-541.
15. Doble, N. D., Banga, J. P., Pope, R., Lalor, E., Kilduff, P. and McGregor, A. M., Autoantibodies to the thyroid microsomal/thyroid peroxidase antigen are polyclonal and directed to several distinct antigenic sites, Immunology 1988. 64: 23-29.
16. Yokoyama, N., Taurog, A. and Klee, G. G., Thyroid peroxidase and thyroid microsomal antibodies. J. Clin. Endocrinol. Metab. 1989. 68: 766-773.
17. Okamoto, Y., Hamada, N., Saito, H., Ohno, M., Noh, J., lto, K. and Morii, H., Thyroid peroxidase activity-inhibiting immunoglobulins in patients with autoimmune thyroid disease. J. Clin. Endocrinol. Metab. 1989. 68: 730-734.
18. Ruf, J., Ferrand, M., Durand-Gorde, J.-M., De Micco, C. and Carayon, P., Significance of thyroglobulin antibodies cross-reactive with thyroperoxidase (TGPO antibodies) in individual patients and immunized mice. Clin. Exp. Immunol. 1993. 92: 65-72.
19. Ruf, J., Carayon, P., Saries-Philip, N., Kourilsky, F. and Lissitzky, S., Specificity of monoclonal antibodies against human thyroglobulin: comparison with autoimmune antibodies. EMBO J. 1983. 2: 1821-1826.
20. Ruf, J., Toubert, M. E., Czarnocka, B., Durand-Gorde, J. M., Ferrand, M. and Carayon, P., Relationship between immunological structure and biochemical properties of human thyroid peroxidase. Endocrinology 1989. 125: 1211-1218.
21. Bona, C.-A., Finley, S., Waters, S. and Kunkel, H. G., Anti-immunoglobulin antibodies. III. Properties of sequential anti-idiotypic antibodies to heterologous anti-globulins. Detection of reactivity of anti-idiotype antibodies with epitopes of Fc fragments (homobodies) and with epitopes and idiotopes (epibodies). J. Exp. Med. 1982. 156: 986-999.
22. Migliorini, P., Ardman, B., Kaburaki, J. and Schwartz, R. S., Parallel sets of autoantibodies in MRL-lpr/lpr mice. An anti-DNA, anti-SmRNP, anti-gp70 network. J. Exp. Med. 1987. 165: 483-499.
23. Bigazzi, P. E., Michaelson, J. H. and Potter, N. T., Epibodies in autoimmunity: antisera against autoantibodies to the renal glomerular basement membrane react with idiotypes as well as with autoantigens. J. Autoimmun. 1989. 5: 3-16.
24. Dwyer, D. S., Vakil, M. and Kearney, J. F., Idiotypic network connectivity and a possible cause of myasthenia gravis. J. Exp. Med. 1986. 164: 1310-1318.
25. Kang, C.-Y. and Köhler, H., Immunoglobulin with complementarity paratope and idiotope. J. Exp. Med. 1986. 163: 787-796.
26. Kaveri, S.-V., Halpern, R., Kang, C.-Y. and Köhler, H., Self-binding antibodies (autobodies) form specific complexes in solution. J. Immunol. 1990. 145: 2533-2538.
27. Kang, C.-Y., Cheng, H. L., Rudikoff, S. and Köhler, H., Idiotypic self-binding of a dominant germline idiotype (T15): autobody activity is affected by antibody valency. J. Exp. Med. 1987. 165: 1332-1343.
28. H derived peptide. Science 1988. 240: 1034-1036.
29. Chapman, P. B., Yuasa, H. and Houghton, A. N., Homophilic binding of mouse monoclonal antibodies against GD3 ganglioside. J. Immunol. 1990. 145: 891-898.
30. Yan, X., Evans, S. V, Kaminki, M. J., Gillies, S. D., Reisfeld, R. A., Houghton, A. N. and Chapman, P. B., Characterization of an Ig VH idiotope that results in specific homophilic binding and increased avidity for antigen. J. Immunol. 1996. 157: 1582-1588.
31. Kaveri, S. V, Wang, H., Rowen, D., Kazatchkine, M. D. and Köhler, H., Monoclonal anti-idiotypic antibodies against human anti-thyroglobulin autoantibodies recognize idiotopes shared by disease-associated and natural anti-thyroglobulin autoantibodies. Clin. Immunol. Immunopathol. 1993. 69: 333-340.
32. Ruf, J., Feldt-Rasmussen, U., Hegedüs, L., Ferrand, M. and Carayon, P., Bispecific thyroglobulin and thyroperoxidase autoantibodies in patients with various thyroid and autoimmune diseases. J. Clin. Endocrinol. Metab. 1994. 79: 1404-1409.
33. Carayanniotis, G., Chronopoulou, E. and Rao, V. P., Distinct genetic pattern of mouse susceptibility to thyroiditis induced by a novel thyroglobulin peptide. Immunogenetics 1994. 39: 21-28.
34. Vladutiu, A. and Rose, N. R., Autoimmune murine thyroiditis: relation to histocompatibility (H-2) type. Science 1971. 174: 1137-1139.
35. Avrameas, S., Natural autoantibodies: self-recognition and physiological autoimmunity. In Shoenfeld, Y. and Isenberg, D. A. (Eds.) Natural autoantibodies. Their physiological role and regulatory significance. CRC press, Boca Raton 1993, p 1.
36. Song, Y.-H., Li, Y. and Maclaren, N. K., The nature of autoantigens targeted in autoimmune endocrine diseases, Immunol. Today 1996. 17: 232-238.
37. Mallet, B., Lejeune, R-J., Ruf, J., Piechaczyk, M., Marriq, C. and Carayon, P., Tyrosine iodination and iodotyrosyl coupling of the N-terminal thyroid hormone forming site of human thyroglobulin modulate its binding to auto- and monoclonal antibodies. Mol. Cell. Endocrinol. 1992. 88: 89-95.
38. Kong, Y.-C. M., McCormick, D. J., Wan, Q., Motte, R. W., Fuller, B. E., Giraldo, A. A. and David, C. S., Primary hormonogenic sites as conserved autoepitopes on thyroglobulin in murine autoimmune thyroiditis. J. Immunol. 1995. 155: 5847-5854.
39. Braley-Mullen, H. and Sharp, G. C., A thyroxine-containing thyroglobulin peptide induces both lymphocytic and granulomatous forms of experimental autoimmune thyroiditis. J. Autoimmun. 1997. 10: 531-540.
40. Cohen, I. R., The cognitive paradigm and the immunological homunculus. Immunol. Today 1992.13: 490-494.
41. Zouali, M.,Isenberg, D. A. and Morrow, W. J. W., Idiotype manipulation for autoimmune diseases: where are we going? Autoimmunity 1996. 24: 55-63.
42. Marriq, C., Rolland, M. and Lissitzky, S., Polypeptide chains of 19-S thyroglobulin from several mammalian species and of porcine 27-S iodoprotein. Eur. J. Biochem. 1977. 79: 143-149.
43. Marriq, C., Lejeune, P. J., Venot, N., Rolland, M. and Lissitzky, S., Characterization of an hormonogenic domain from human thyroglobulin. FEBS Lett. 1986. 207: 302-306.
44. Czarnocka, B., Ruf, J., Ferrand, M., Carayon, P. and Lissitzky, S., Purification of the human thyroid peroxidase and its identification as the microsomal antigen involved in autoimmune thyroid diseases. FEBS Lett. 1985. 190: 147-152.
45. Kaufman, K. D., Rapoport, B., Seto, P., Chazenbalk, B. and Magnusson, R. P., Generation of recombinant, enzymatically active human thyroid peroxidase and its recognition by antibodies in the sera of patients with Hashimoto's thyroiditis. J. Clin. Invest. 1989. 84: 394-403.
46. Kearney, J. K., Radbruch, A., Lisegang, B. and Rajewsky, K., A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines. J. Immunol. 1979. 123: 1548-1550.