A tyrosine kinase signaling pathway, regulated by calcium entry and dissociated from tyrosine phosphorylation of phospholipase Cγ-1, is involved in inositol phosphate production by activated G protein-coupled receptors in myometrium

Journal of Pharmacology and Experimental Therapeutics

Volumn 289, Issue 2, 1999, Pages 1022-1030

  Palmier, Bruno ^a   Vacher, Monique ^a   Harbon, Simone ^a   Leiber, Denis ^a,b  

^a CNRS   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; BOMBESIN; BOMBESIN RECEPTOR; CALCIUM CHANNEL; CALCIUM ION; CARBACHOL; ENDOTHELIN 1; FLUOROALUMINATE; FURA 2; GENISTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL PHOSPHATE; MUSCARINIC RECEPTOR; NIFEDIPINE; OXYTOCIN; PERTUSSIS TOXIN; PERVANADATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE C; PROTEIN TYROSINE KINASE; TYRPHOSTIN;

ANIMAL CELL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; HYDROLYSIS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MYOMETRIUM; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; UTERUS CONTRACTION;

ANIMALS; CALCIUM; CALCIUM CHANNELS; ENZYME INHIBITORS; FEMALE; FLUORESCENT DYES; FURA-2; GTP-BINDING PROTEINS; IMMUNOBLOTTING; INOSITOL PHOSPHATES; ISOENZYMES; MYOMETRIUM; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TYROSINE; UTERINE CONTRACTION; UTERUS;

EID: 0032927058     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (43)

1. Akiyama T, Ishida J, Nakagawa S, Ogawara H, Watanabe S-I, Itoh N, Shibuya M and Fukami Y (1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262:5592-5595.
2. Amédée T, Mironneau C and Mironneau J (1986) Isolation and contractile responses of single pregnant rat myometrial cells in short-term primary culture and the effects of pharmacological and electrical stimuli. Br J Pharmacol 188:873-880.
3. Amiot F, Leiber D, Marc S and Harbon S (1993) GRP-preferring bombesin receptors increase generation of inositol phosphates and tension in rat myometrium. Am J Physiol 265:C1579-C1587.
4. Arnaudeau S, Leprêtre N and Mironneau J (1994) Oxytocin mobilizes calcium from a unique heparin-sensitive and thapsigargin-sensitive store in single myometrial cells from pregnant rats. Pfluegers Arch 428:51-59.
5. Berridge MJ (1993) Inositol trisphosphate and calcium signalling. Nature (London) 361:315-325.
6. Carpenter G, Hernandez-Sotomayor T and Jones G (1993) Tyrosine phosphorylation of phospholipase C-γ1. Adv Second Messenger Phosphoprotein Res 28:179-185.
7. 3 cells. J Biol Chem 271:9441-9446.
8. Di Salvo JG and Nelson SR (1998) Stimulation of G-protein coupled receptors in vascular smooth muscle cells induces tyrosine kinase dependent increases in calcium without tyrosine phosphorylation of phospholipase C-γ1. FEBS Lett 422: 85-88.
9. 2+ sensitivity for contraction of smooth muscle. Can J Physiol Pharmacol 72:1434-1439
10. ++ influx, a cAMP-independent mechanism. J Pharmacol Exp Ther 276:130-136.
11. 2+ entry-mediated generation of inositol phosphates in the guinea pig myometrium, a cyclic AMP-independent event. Mol Pharmacol 41:509-519.
12. Dokhac L, Naze S and Harbon S (1994) Endothelin receptor type A signals both the accumulation of inositol phosphates and the inhibition of cyclic AMP generation in rat myometrium: stimulation and desensitization. Mol Pharmacol 46:485-494.
13. Fischer EH, Charbonneau H and Tonks NK (1991) Protein tyrosine phosphatases: A diverse family of intracellular and transmembrane enzymes. Science (Wash DC) 253:401-406.
14. 2+ mobilization in swine carotid media. Am J Physiol 268:C1425-C1429.
15. Gusovsky F, Lueders JE, Kohn EC and Felder CC (1993) Muscarinic receptor-mediated tyrosine phosphorylation of phospholipase C-γ: An alternative mechanism for cholinergic-induced phosphoinositide breakdown. J Biol Chem 268:7768-7772.
16. Hatakeyama N, Mukhopadhyay D, Goyal RK and Akbarali HI (1996) Tyrosine kinase-dependent modulation of calcium entry in rabbit colonic muscularis mucosae. Am J Physiol 270:C1780-C1789.
17. Hollenberg MD (1994) Tyrosine kinase pathways and the regulation of smooth muscle contractility. Trends Pharmacol Sci 15:108-114.
18. Ku CY, Quian A, Wen Y, Anwers K and Sanborn BM (1995) Oxytocin stimulates myometrial guanosine triphosphatase and phospholipase-C activities via coupling to Gαq/11. Endocrinology 136:1509-1515.
19. Kusaka M and Sperelakis N (1995) Inhibition of L-type calcium current by genistein, a tyrosine kinase inhibitor, in pregnant rat myometrial cells. Biochim Biophys Acta 1240:196-200.
20. Laemmli UK (1970) Cleavage of structural protein during assembly of the head of bacteriophage T4. Nature (London) 227:680-685.
21. 11α in rat myometrium during gestation. Am J Physiol 71:C895-C904.
22. Leeb-Lundberg LMF and Song XH (1991) Bradykinin and bombesin rapidly stimulate tyrosine phosphorylation of a 120-kDa group of proteins in Swiss 3T3 cells. J Biol Chem 266:7746-7749.
23. Leiber D, Marc S and Harbon S (1990) Pharmacological evidence for distinct muscarinic receptor subtypes coupled to the inhibition of adenylate cyclase and to the increased generation of inositol phosphates in the guinea pig myometrium. J Pharmacol Exp Ther 252:800-809.
24. 2+-induced regulation of ion channel and MAP kinase functions. Nature (Lond) 376:737-745.
25. Levitzki A (1992) Tyrphostins: Tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction. FASEB J 6:3275-3282.
26. Liao F, Shin HS and Rhee SG (1993) In vitro tyrosine phosphorylation of PLC-γ1 and PLC-γ2 by Src-family protein tyrosine kinases. Biochem Biophys Res Commun 191:1028-1033.
27. Liu CY and Sturek M (1996) Attenuation of endothelin-1-induced calcium response by tyrosine kinase inhibitors in vascular smooth muscle cells. Am J Physiol 270:C1825-C1833.
28. Liu WW, Mattingly RR and Garrison JC (1996) Transformation of rat-1 fibroblasts with the v-src oncogene increases the tyrosine phosphorylation state and activity of the α subunit of Gq/G11. Proc Natl Acad Sci USA 93:8258-8263.
29. Lowry OH, Rosebrough NF, Farr AL and Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265-275.
30. Malarkey K, Belham CM, Paul A, Graham A, McLees A, Scott PH and Plevin R (1995) The regulation of tyrosine kinase signalling pathways by growth factor and G-protein-coupled receptors. Biochem J 309:361-375.
31. Marc S, Leiber D and Harbon S (1988) Fluoroaluminates mimic muscarinic and oxytocin receptor-mediated generation of inositol phosphates and contraction in the guinea-pig myometrium. Biochem J 255:705-713.
32. Marrero MB, Paxton WG, Duff JL, Berk BC and Bernstein KE (1994) Angiotensin II stimulation tyrosine phosphorylation of phospholipase C-γ1 in vascular smooth muscle Cells. J Biol Chem 269:10935-10939.
33. c-src antibodies inhibit the angiotensin II activation of phospholipase C-γ1 in rat aortic smooth muscle cells. J Biol Chem 270:15734-15738.
34. Palmier B, Leiber D and Harbon S (1996) Pervanadate mediated an increased generation of inositol phosphates and tension in rat myometrium: Activation and phosphorylation of phospholipase C-γ1. Biol Reprod 54:1383-1389
35. 3 production and amylase release in pancreatic acini. Am J Physiol 266:G363-G371.
36. Post GR and Heller Brown J (1996) G protein-coupled receptors and signaling pathways regulating growth responses. FASEB J 10:741-749.
37. Pumiglia KM, Lau LF, Huang CK, Burroughs S and Feinstein B (1992) Activation of signal transduction in platelets by the tyrosine phosphatase inhibitor pervanadate (vanadyl hydroperoxide). Biochem J 286:441-449.
38. Saifedine M, Laniyonu A, Yang SG and Hollenberg MD (1992) Tyrosine kinase inhibitors and the contractile action of angiotensin-II in vascular tissue. Pharmacol Commun 1:177-184.
39. 2+ mobilization in cardiac cells. Circ Res 78:102-109.
40. Triggle DJ and Rampe D (1989) 1,4-Dihydropyridine activators and antagonists: structural and functional distinctions. Trends Pharmacol Sci 10:507-511.
41. Umemori H, Inoue T, Kume S, Sekiyama N, Nagao M, Itoh H, Nakaanishi S, Mikoshiba K and Yamamoto T (1997) Activation of G protein Gq/G11 through tyrosine phosphorylation of the α subunit. Science (Wash DC) 276:1878-1881.
42. van der Geer P and Hunter T (1994) Receptor protein-tyrosine kinases and their signal transduction pathways. Annu Rev Cell Biol 10:251-337.
43. Wijetunge S and Hughes AD (1995) pp60c-src increases voltage-operated calcium channel currents in vascular smooth muscle cells. Biochem Biophys Res Commun 217:1039-1044.