Iron uptake promotes hyperoxic injury to alveolar macrophages

American Journal of Respiratory and Critical Care Medicine

Volumn 159, Issue 1, 1999, Pages 100-106

  Wesselius, Lewis J ^a   Williams, Wade L ^b   Bailey, Kirstin ^b   Vamos, Susan ^b   O'Brien ladner, Amy R ^b   Wiegmann, Thomas ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; FERRITIN; FERROUS CHLORIDE; INDO 1; LACTATE DEHYDROGENASE; OXYGEN;

ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYPEROXIA; IRON TRANSPORT; LUNG ALVEOLUS MACROPHAGE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SACCHAROMYCES CEREVISIAE;

EID: 0032926181     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.159.1.9801033     Document Type: Article

References (35)

1. Halliwell, B., and J. M. C. Gutteridge. 1986. Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts. Arch. Biochem. Biophys. 246:501-514.
2. Aust, S. D. 1995. Ferritin as a source of iron and protection from iron-induced toxicities. Toxicol. Lett. 82/83:941-944.
3. Breuer, W., E. Greenberg, and Z. I. Cabantchik. 1997. Newly delivered transferrin iron and oxidative cell injury. FEBS Lett. 403:213-219.
4. Gutteridge, J. M. C., S. Mumby, G. J. Quinlan, K. F. Chung, and T. W. Evans. 1996. Pro-oxidant iron is present in human pulmonary epithelial lining fluid: implications for oxiditive stress in the lung. Biochem. Biophys. Res. Commun. 220:1024-1027.
5. Baz, M. A., A. J. Ghio, V. L. Roggli, V. F. Tapson, and C. A. Piantadosi. 1997. Iron accumulation in lung allografts after transplantation. Chest 112:435-439.
6. Wesselius, L. J., M. E. Nelson, and B. S. Skikne. 1994. Increased release of ferritin and iron by iron-loaded alveolar macrophages in cigarette smokers. Am. J. Respir. Crit. Care Med. 150:690-695.
7. Nelson, M. E., A. R. O'Brien-Ladner, and L. J. Wesselius. 1996. Regional variation in iron and iron-binding proteins within the lungs of cigarette smokers. Am. J. Respir. Crit. Care Med. 153:1353-1358.
8. Olakanmi, O., J. B. Stokes, and B. E. Britigan. 1994. Acquisition of iron bound to low molecular weight chelates by human monocyte-derived macrophages. J. Immunol. 153:2691-2703.
9. Wesselius, L. J., I. M. Smirnov, M. E. Nelson, A. R. O'Brien-Ladner, C. H. Flowers, and B. S. Skikne. 1996. Alveolar macrophages accumulate iron and ferritin after in vivo exposure to iron or tungsten dusts. J. Lab. Clin. Med. 127:401-409.
10. Olakanmi, O., S. E. McGowan, M. B. Hayek, and B. E. Britigan. 1993. Iron sequestration by macrophages decreases the potential for extracellular hydroxyl radical formation. J. Clin. Invest. 91:889-899.
11. Wesselius, L. J., C. H. Flowers, and B. S. Skikne. 1992. Alveolar macrophage content of isoferritins and transferrin. Am. Rev. Respir. Dis. 145:311-316.
12. Gille, J. J. P., C. G. M. Vanberkel, and H. Joenje. 1994. Mutagenicity of metabolic oxygen radicals in mammalian cell cultures. Carcinogenesis 15:2695-2699.
13. Aerts, C., B. Wallaert, P. Gosset, and C. Voisin. 1995. Relationship between oxygen-induced alveolar macrophage injury and cell antioxidant defense. J. Appl. Toxicol. 15:53-58.
14. Harada, R. N., A. E. Vatter, and J. E. Repine. 1983. Oxygen radical scavengers protect alveolar macrophages from hyperoxic injury in vitro. Am. Rev. Respir. Dis. 128:761-762.
15. Suttorp, N., and L. M. Simon. 1983. Decreased bactericidal function and impaired respiratory burst in lung macrophages after sustained in vitro hyperoxia. Am. Rev. Respir. Dis. 128:486-490.
16. Raffin, T. A., L. M. Simon, D. Braun, J. Theodore, and E. D. Robin. 1980. Impairment of phagocytosis by moderate hyperoxia (40 to 60 percent oxygen) in lung macrophages. Lab. Invest. 42:622-626.
17. Forman, H. J., J. J. Williams, J. Nelson, R. P. Daniele, and A. B. Fisher. 1982. Hyperoxia inhibits stimulated superoxide release by rat alveolar macrophages. J. Appl. Physiol. (Respir. Environ. Exerc. Physiol.) 53:685-689.
18. + and membrane potential. Arch. Biochem. Biophys. 259:457-465.
19. O'Brien-Ladner, A. R., M. E. Nelson, B. D. Cowley, K. Bailey, and L. J. Wesselius. 1995. Hyperoxia amplifies TNF-α production in LPS-stimulated human alveolar macrophages. Am. J. Respir. Cell Mol. Biol. 12:275-279.
20. Skikne, B. S. 1987. A commercial electrochemical method evaluated for measurement of iron status. Clin. Chem. 33:1645-1647.
21. Whittaker, P., B. S. Skikne, A. M. Covell, et al. 1989. Duodenal iron proteins in idiopathic hemochromatosis. J. Clin. Invest. 83:261-267.
22. Magae, J., T. Nagi, K. Takaku, T. Kataoka, H. Koshino, M. Uramoto, and K. Nagai. 1994. Screening for specific inhibitors of phagocytosis of thioglycollate-elicited macrophages. Biosci. Biotech. Biochem. 58:104-107.
23. Vamos, S., L. W. Welling, and T. B. Wiegmann. 1995. Maintenance of bradykinin-induced intracellular calcium response of MDCK cells depends on extracellular calcium. J. Lab. Clin. Med. 125:470-478.
24. Morris, S. J., D. M. Beatty, L. W. Welling, and T. B. Wiegmann. 1991. Instrumentation for simultaneous kinetic imaging of multiple fluorophores in single living cells. SPIE 1428:148-158.
25. Lattanzio, F. A. 1990. The effects of pH and temperature on fluorescent calcium indicators as determined with chelex-100 EDTA buffer systems. Biochem. Biophys. Res. Commun. 171:102-108.
26. Lattanzio, F. A., and D. K. Bartchat. 1991. The effects of pH on rate constants, ion selectivity and thermodynamics of fluorescent calcium and magnesium indicators. Biochem. Biophys. Res. Commun. 177:184-191.
27. 2+] and pH in single MDCK and glomerular epithelial cells. Am. J. Physiol. 265:C1184-1190.
28. Fang, R., and A. E. Aust. 1997. Induction of ferritin synthesis in human lung epithelial cells treated with crocidolite asbestos. Arch. Biochem. Biophys. 340:369-375.
29. Ghio, A. J., R. H. Jaskot, and G. E. Hatch. 1994. Lung injury after silica instillation is associated with an accumulation of iron in rats. Am. J. Physiol. 267 (Lung Cell Mol. Physiol. 11):L686-L692.
30. Santambrogio, P., S. Levi, A. Cozzi, E. Rovida, A. Albertini, and P. Arosio. 1993. Production and characterization of recombinant heteropolymers of human ferritin H and L chains. J. Biol. Chem. 268:12744-12748.
31. Cairo, G., E. Castrusini, G. Minotti, and A. Bernelli-Zazzera. 1996. Superoxide and hydrogen peroxide-dependent inhibition of iron regulatory protein activity: a protective stratagem against oxidative injury. FASEB J. 10:1326-1335.
32. Ryan, T. P., R. F. Krzesicki, D. P. Blakeman, J. E. Chin, R. L. Griffin, I. M. Richards, S. D. Aust, and T. W. Petry. 1997. Pulmonary ferritin, differential effects of hyperoxic lung injury on subunit mRNA levels. Free Radic. Biol. Med. 22:901-908.
33. Rojanasakul, Y., L. Wang, A. H. Hoffman, X. Shi, N. S. Dalal, D. E. Banks, and J. K. H. Ma. 1993. Mechanisms of hydroxyl free radical-induced cellular injury and calcium overloading in alveolar macrophages. Am. J. Respir. Cell Mol. Biol. 8:377-383.
34. Nicotera, P., G. Bellomo, and S. Orrenius. 1992. Calcium-mediated mechanisms in chemically induced cell death. Annu. Rev. Pharmacol. Toxicol. 32:449-470.
35. Steinberg, K. P., J. A. Milbuerg, T. R. Martin, R. J. Maunder, B. A. Cockrill, and L. D. Hudson. 1994. Evolution of bronchoalveolar cell populations in the adult respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 150:113-122.