Structure and function of cardiac sodium and potassium channels

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 273, Issue 2 42-2, 1997, Pages

  Roden, Dan M ^a   George Jr , Alfred L ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Arrhythmia; Cardiac electrophysiology; Ion channels; Ion currents

Indexed keywords

GENE PRODUCT; ION CHANNEL; POTASSIUM CHANNEL; POTASSIUM ION; SODIUM CHANNEL; SODIUM ION;

ACTION POTENTIAL; ALPHA CHAIN; BETA CHAIN; ELECTROPHYSIOLOGY; GENE EXPRESSION; GENE STRUCTURE; HEART ARRHYTHMIA; HEART MUSCLE CELL; HUMAN; ION CURRENT; LONG QT SYNDROME; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVIEW; SODIUM CURRENT; STRUCTURE ACTIVITY RELATION;

EID: 0030760007     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1997.273.2.h511     Document Type: Review

References (14)

1. Abrahamsson, C., M. Palmer, B. Ljung, G. Duker, C. Baeaernhielm, L. Carlsson, and B. Danielsson. Induction of rhythm abnormalities in the fetal rat heart. A tentative mechanism for the embryotoxic effect of the class III antiarrhythmic agent almokalant. Cardiovasc. Res. 28: 337-344, 1994.
2. + channel. Neuron 16: 1169-1177, 1996.
3. Ahmed, C. M., D. H. Ware, S. C. Lee, C. D. Patten, A. V. Ferrer-Montiel, A. F. Schinder, J. D. McPherson, C. B. Wagner-McPherson, J. J. Wasmuth, G. A. Evans, and M. Montai. Primary structure, chromosomal localization, and functional expression of a voltage-gated sodium channel from human brain. Proc. Natl. Acad. Sci. USA 89: 8220-8224, 1992.
4. Akopian, A. N., L. Sivilotti, and J. N. Wood. A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature 379: 257-262, 1996.
5. Antzelevitch, C., S. Sicouri, S. H. Litovsky, A. Lukas, S. C. Krishnan, J. M. Di Diego, G. A. Gintant, and D. W. Liu. Heterogeneity within the ventricular wall: electrophysiology and pharmacology of epicardial, endocardial, and M cells. Circ. Res. 69: 1427-1449, 1991.
6. Armstrong, C. M. Inactivation of the potassium conductance and related phenomena caused by quaternary ammonium ion injection in squid axons. J. Gen. Physiol. 54: 553-575, 1969.
7. Aronson, R. S. Mechanisms of arrhythmias in ventricular hypertrophy. J. Cardiovasc. Electrophysiol. 2: 249-261, 1991.
8. Backx, P. H., and E. Marban. Background potassium current active during the plateau of the action potential in guinea pig ventricular myocytes. Circ. Res. 72: 890-900, 1993.
9. Backx, P. H., D. T. Yue, J. H. Lawrence, E. Marban, and G. F. Tomaselli. Molecular localization of an ion-binding site within the pore of mammalian sodium channels. Science 257: 248-251, 1992.
10. Balser, J. R., P. B. Bennett, and D. M. Roden. Time-dependent outward current in guinea pig ventricular myocytes. Gating kinetics of the delayed rectifier. J. Gen. Physiol. 96: 835-863, 1990.
11. Balser, J. R., H. B. Nuss, D. W. Orias, E. Marban, G. F. Tomaselli, and J. H. Lawrence. Mechanism of lidocaine block reinterpreted as catalysis of fast inactivation (Abstract). Circulation 94: 1-45, 1996.
12. Ks cardiac potassium current. Nature 384: 78-80, 1996.
13. + channels? Circ. Res. 77: 361-369, 1995.
14. Benitah, J. P., G. F. Tomaselli, and E. Marban. Adjacent pore-lining residues within sodium channels identified by paired cysteine mutagenesis. Proc. Natl. Acad. Sci. USA 93: 7392-7396, 1996.