Adaptive and non-adaptive responses in rats exposed to ozone, alone and in mixtures, with acidic aerosols

Inhalation Toxicology

Volumn 11, Issue 3, 1999, Pages 249-264

  Kleinman, Michael T ^a   Mautz, William J ^b   Bjarnason, Stephen ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF HAWAII AT HILO   (United States)

^c HEALTH CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0032925207     PISSN: 08958378     EISSN: None     Source Type: Journal    
DOI: 10.1080/089583799197177     Document Type: Article

References (43)

1. Becker, S., Madden, M. C., Newman, S. L., Devlin, R. B., and Koren, H. S. 1991. Modulation of human alveolar macrophage properties by ozone exposure in vitro. Toxicol. Appl. Pharmacol. 110:403-415.
2. Bedi, J. F., Horvath, S. M., and Drechsler-Parks, D. M. 1989. Adaptation by older individuals repeatedly exposed to 0.45 parts per million ozone for two hours. J. Air Pollut. Control Assoc. 39:194-199.
3. 3. J. Toxicol. Environ. Health 21:73-87.
4. Bromberg, P. A., Ranga, V., and Stutts, M. J. 1991. Effects of Ozone on Airway Epithelial Permeability and Ion Transport. Research Report, Health Effects Institute, December, 48:1-22.
5. Chen, L. C., Miller, P. D., Lam, H. F., Guty, J., and Amdur, M. O. 1991. Sulfuric acid-layered ultrafine particles potentiate ozone-induced airway injury. J. Toxicol. Environ. Health 34:337-352.
6. Currie, W. D., van Schaik, S. M., Vargas, I., and Enhorning, G. 1998. Ozone affects breathing and pulmonary surfactant function in mice. Toxicologist 125:21-30.
7. Duan, X., Buckpitt, A. R., Pinkerton, K. E., Ji, C., and Plopper, C. G. 1996. Ozone-induced alterations in glutathione in lung subcompartments of rats and monkeys. Am. J. Respir. Cell Mol. Biol. 14: 70-75.
8. Elias, H., and Hyde, D. M. 1980. An elementary introduction to stereology quantitative microscopy. Am. J. Anat. 159:412-446.
9. Folinsbee, L. J., McDonnell, W. F., and Horstman, D. H. 1988. Pulmonary function and symptom responses after 6.6-hour exposure to 0.12 ppm ozone with moderate exercise. J. Air Pollut. Control Assoc. 38:28-35.
10. 2max. J. Appl. Physiol. 61:960-966.
11. Frampton, M. W., Morrow, P. E., Cox, C., Levy, P. C., Condemi, J. J., Speers, D., Gibb, F. R., and Utell, M. J. 1995. Sulfuric acid aerosol followed by ozone exposure in healthy and asthmatic subjects. Environ. Res. 69:1-14.
12. Harkema, J. R., Barr, E. B., and Hotchkiss, J. A. 1997. Responses of rat nasal epithelium to short- and long-term exposures of ozone: Image analysis of epithelial injury, adaptation and repair. Microsc. Res. Tech. 36:276-286.
13. Horstman, D. H., Folinsbee, L. J., Ives, P. J., Abdul-Salaam, S., and McDonnell, W. F. 1990. Ozone concentration and pulmonary response relationships for 6.6-hour exposures with five hours of moderate exercise to 0.08, 0.10, and 0.12 ppm. Am. Rev. Respir. Dis. 142:1158-1163.
14. Kleinman, M. T. 1991. Effects of ozone on pulmonary function: the relationship of response to dose. J. Expos. Anal. Environ. Epidemiol. 1:309-325.
15. Kleinman, M. T., Bhalla, D. K., Ziegler, B., Bucher-Evans, S., and McClure, T. R. 1993. Effects of inhaled fine particles and ozone on pulmonary macrophages and epithelia. Inhal. Toxicol. 5: 371-388.
16. Kleinman, M. T., Bhalla, D. K., Mautz, W. J., and Phalen, R. F. 19 . Cellular and immunologic injury with PM10 inhalation. Inhal. Toxicol. 7:589-602.
17. Kodavanti, U. P., Hatch, G. E., Starcher, B., Giri, S. N., Winsett, D., and Costa, D. L. 1995. Ozone-induced pulmonary functional, pathological, and biochemical changes in normal and vitamin C-deficient guinea pigs. Fundam. Appl. Toxicol. 24:154-164.
18. Koren, H. S., and Bromberg P. A. 1995. Respiratory responses of asthmatics to ozone. Int. Arch. Allergy Immunol. 107:236-238.
19. Koren, H. S., Devlin, R. B., Graham, D. E., Mann, R., McGee, M. P., Horstman, D. H., Kozumbo, W. J., Becker, S., House, D. E., and McDonnell, W. F. 1989. Ozone-induced inflammation in the lower airways of human subjects. Am. Rev. Respir. Dis. 139:407-415.
20. Kulle, T. J., Sauder, L. R., Kerr, H. D., Farrell, B. P., Bermel, M. S., and Smith, D. M. 1982. Duration of pulmonary function adaptation to ozone in humans. Am. Ind. Hyg. Assoc. J. 43:832-837.
21. Last, J. A., and Pinkerton, K. E. 1997. Chronic exposure of rats to ozone and sulfuric acid aerosol: biochemical and structural responses. Toxicologist 116:133-146.
22. Last, J. A., Gerriets, J. E., and Hyde, D. M. 1983. Synergistic effects on rat lungs of mixtures of oxidant air pollutants ozone or nitrogen dioxide and respirable aerosols. Am. Rev. Respir. Dis. 128: 539-544.
23. Linn, W. S., Medway, D. A., Anzar, U. T., Valencia, L. M., Spier, C. E., Tsao, F. S., Fischer, D. A., and Hackney, J. D. 1982. Persistence of adaptation to ozone in volunteers exposed repeatedly for six weeks. Am. Rev. Respir. Dis. 125:491-495.
24. Mautz, W. J., and Bufalino, C. 1989. Breathing pattern and metabolic rate responses of rats exposed to ozone. Respir. Physiol. 76:69-77.
25. Mautz, W. J., McClure, T. R., Reischl, P., Phalen, R. F., and Crocker, T. T. 1985. Enhancement of ozone-induced lung injury by exercise. J. Toxicol. Environ. Health 16:841-854.
26. Mautz, W. J., Kleinman, M. T., Phalen, R. F., and Crocker, T. T. 1988. Effects of exercise exposure on toxic interactions between inhaled oxidant and aldehyde air pollutants. J. Toxicol. Environ. Health 25:165-177.
27. Menzel, D. B. 1984. Ozone: An overview of its toxicity in man and animals. J. Toxicol. Environ. Health 13:184-204.
28. McKinney, W. J., Jaskot, R. H., Richards, J. H., Costa, D. L., and Dreher, K. L. 1998. Cytokine mediation of ozone-induced pulmonary adaptation. Am. J. Respir. Cell Mol. Biol. 18:695-705.
29. Moffatt, R. K., Hyde, D. M., Plopper, C. G., Tyler, W. S., and Putney, L. F. 1987. Ozone-induced adaptive and reactive cellular changes in respiratory bronchioles of bonnet monkeys. Exp. Lung Res. 12:57-74.
30. Nikula, K. J., Wilson, D. W., Dungworth, D. L., and Plopper, C. G. 1988. In vitro evidence of cellular adaptation to ozone toxicity in the rat trachea. Toxicol. Appl. Pharmacol. 93:394-402.
31. Paterson, J. F., Hammond, M. D., Montgomery, M. R., Sharp, J. T., Farrier, S. E., and Balis, J. U. 1992. Acute ozone-induced lung injury in rats: Structural-functional relationships of developing alveolar edema. Toxicol. Appl. Pharmacol. 117:37-45.
32. Prasad, S. B., Rao, V. S., Mannix, R. C., and Phalen R. F. 1988. Effects of pollutant atmospheres on surface receptors of pulmonary macrophages. J. Toxicol. Environ. Health 24:385-402.
33. Sasaki, K., Nadel, J. A., and Hahn, H. L. 1995. Effect of ozone on breathing in dogs: Vagal and non-vagal mechanisms. J. Appl. Physiol. 62:15-26.
34. Schlesinger, R. B., Zelikoff, J. T., Chen, L. C., and Kinney, P. L. 1992a. Assessment of toxicologic interactions resulting from acute inhalation exposure to sulfuric acid and ozone mixtures. Toxicol. Appl. Pharmacol. 115:183-190.
35. Schlesinger, R. B., Gorczynski, J. E., Dennison, J., Richards, L., Kinney, P. L., and Bosland, M. C. 1992b. Long-term intermittent exposure to sulfuric acid aerosol, ozone, and their combination: alterations in tracheobronchial mucociliary clearance and epithelial secretory cells. Exp. Lung Res. 18:505-534.
36. Shelley, S. A. 1994. Oxidant-induced alterations of lung surfactant system. J. Florida Med. Assoc. 81:49-51.
37. Silbaugh, S. A., and Mauderly, J. L. 1986. Effects of ozone and sulfuric acic aerosol on gas trapping in the guinea pig lung. J. Toxicol. Environ. Health 18:133-141.
38. Stevens, T. P., McBride, J. T., Peake, J. L., Pinkerton, K. E., and Stripp, B. R. 1997. Cell proliferation contributes to PNEC hyperplasia after acute airway injury. Am. J. Physiol. 272:L486-493.
39. Sun, J., and Chung, K. F. 1997. Airway inflammation despite loss of bronchial hyper-responsiveness after multiple ozone exposures. Respir. Med. 91:47-55.
40. Tepper, J. S., Costa, D. L., Lehmann, J. R., Weber, M. F., and Hatch, G. E. 1989. Unattenuated structural and biochemical alterations in the rat lung during functional adaptation to ozone. Am. Rev. Respir. Dis. 140:493-501.
41. Tepper, J. S., Wiester, M. J., Weber, M. F., and Menache, M. G. 1990. Measurements of cardiopulmonary response in awake rats during acute exposure to near-ambient concentrations of ozone. J. Appl. Toxicol. 10:7-15.
42. Wardlaw, A. J. 1993. Air pollution and allergic disease. Report of a Working Party of the British Society for Allergy and Clinical Immunology. Clin. Exp. Allergy 25:6-8.
43. Wiester, M. J., Tepper, J. S., Doerfler, D. L., and Costa, D. L. 1995. Ozone adaptation in rats after chronic exposure to a simulated urban profile of ozone. Fundam. Appl. Toxicol. 24:42-51.