Chronic exposure of rats to ozone and sulfuric acid aerosol: Biochemical and structural responses

Toxicology

Volumn 116, Issue 1-3, 1997, Pages 133-146

  Last, Jerold A ^a   Pinkerton, Kent E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acid aerosols; Air pollution; Collagen; Lung; Morphometry; Ozone

Indexed keywords

COLLAGEN; HYDROXYPROLINE; OZONE; SULFURIC ACID;

AEROSOL; AIR POLLUTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG MIXTURE; DRUG TOXICITY; LONG TERM EXPOSURE; LUNG INJURY; MALE; MORPHOMETRICS; PRIORITY JOURNAL; RAT;

AEROSOLS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; HYDROXYPROLINE; LUNG; MALE; OZONE; PULMONARY FIBROSIS; RATS; RATS, SPRAGUE-DAWLEY; SENSITIVITY AND SPECIFICITY; SULFURIC ACIDS; TIME FACTORS;

ANIMALIA;

EID: 0031029039     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(96)03535-4     Document Type: Article

References (39)

1. Alarie, Y.C., Busey, W.M., Krumm, A.A. and Ulrich, C.E. (1973) Long-term continuous exposure to sulfuric acid mist in cynomolgus monkeys and guinea pigs. Arch. Environ. Health 27, 16-24.
2. Alarie, Y.C., Busey, W.M., Krumm, A.A., Ulrich, C.E. and Krantz, R.J. (1975) Long-term exposure to sulfur dioxide, sulfuric acid mist, fly ash, and their mixtures: results of studies in monkeys and guinea pigs. Arch. Environ. Health 30, 254-262.
3. Amdur, M.O., Dubriel, M. and Creasia, D.A. (1978) Respiratory response of guinea pigs to low levels of sulfuric acid. Environ. Res. 15, 418-423.
4. Armstrong, L.C., Watkins, K., Pinkerton, K.E. and Last, J.A. (1994) Collagen mRNA content and distribution in the lungs of rats exposed to ozone. Am. J. Respir. Cell. Mol. Biol. 11, 25-34.
5. Catalano, P.J., Chang, L.L., Harkema, J.R., Kaden, D.A. et al. (1995) Consequences of prolonged inhalation of ozone on F344/N rats: collaborative studies. Research Report No. 65, Health Effects Institute, Cambridge, MA.
6. Cavender, F.L., Williams, J.L., Steinhagen, W.H. and Woods, D. (1977) Thermodynamics and toxicity of sulfuric acid mists. J. Toxicol. Environ. Health 2, 1147-1159.
7. Chow, C.K. and Tappel, A.L. (1972) Enzymatic protective mechanism against lipid peroxidation damage to lungs of ozone-exposed rats. Lipids 7, 518-524.
8. Chow, C.K. and Tappel, A.L. (1973) Activities of pentose shunt and glycolytic enzymes in lungs of ozone-exposed rats. Arch. Environ. Health 26, 205-208.
9. Crapo, J.D., Barry, B.E., Chang, L. and Mercer, R.R. (1984) Alterations in lung structure caused by inhalation of oxidants. J. Toxicol. Environ. Health 13, 310-321.
10. Eustis, S.L., Schwartz, L.W., Kosch, P.C. and Dungworth, D.L. (1981) Chronic bronchiolitis in nonhuman primates after prolonged ozone exposure. Am. J. Pathol. 105, 121-137.
11. Freeman, G., Stephens, R.J., Coffin, D.L. and Stara, J.F. (1973) Changes in dogs' lungs after long-term exposure to ozone. Arch. Environ. Health 26, 209-216.
12. Gallop, P.M. and Paz, M.A. (1975) Post-translational protein modifications, with special attention to collagen and elastin. Physiol. Rev. 55, 418-487.
13. 3. J. Environ. Sci. Health 13, 33-47.
14. Last, J.A. (1988) Biochemical and cellular interrelationships in the development of ozone-induced pulmonary fibrosis. In: A.Y. Watson, R.R. Bates and D. Kennedy (Eds), Air Pollution, the Automobile, and Public Health. Nat. Acad. Sci., Washington, DC, pp. 415-440.
15. Last, J.A. (1991) Global atmospheric change: potential health effects of acid aerosol and oxidant gas mixtures. Environ. Health Perspect. 96, 151-157.
16. Last, J.A. and Cross, C.E. (1978) A new model for health effects of air pollutants: evidence for synergistic effects of mixtures of ozone and sulfuric acid aerosols on rat lungs. J. Lab. Clin. Med. 91, 328-339.
17. Last, J.A. and Greenberg, D.B. (1980) Ozone-induced alterations in collagen metabolism of rat lungs. II. Long-term exposures. Toxicol. Appl. Pharmacol. 55, 108-114.
18. Last, J.A. and Warren, D.L. (1987) Synergistic interaction between nitrogen dioxide and respirable aerosols of sulfuric acid or sodium chloride on rats lungs. Toxicol. Appl. Pharmacol. 90, 34-42.
19. Last, J.A., Greenberg, D.B. and Castleman, W.L. (1979) Ozone-induced alterations in collagen metabolism of rat lungs. Toxicol. Appl. Pharmacol. 51, 247-258.
20. Last, J.A., Gerriets, J.E. and Hyde, D.M. (1983) Synergistic effects on rat lungs of mixtures of oxidant air pollutants (ozone or nitrogen dioxide) and respirable aerosols. Am. Rev. Respir. Dis. 128, 539-544.
21. Last, J.A., Hyde, D.M., and Chang, D.P.Y. (1984) A mechanism of synergistic lung damage by ozone and a respirable aerosol. Exp. Lung Res. 7, 223-236.
22. Mustafa, M.G. and Tierney, D.F. (1978) Biochemical and metabolic changes in the lung with oxygen, ozone, and nitrogen dioxide toxicity. Am. Rev. Respir. Dis. 118, 1061-1090.
23. Naumann, B.D. and Schlesinger, R.B. (1986) Assessment of early alveolar particle clearance and microphage function following an acute inhalation of sulfuric acid mist. Exp. Lung Res. 11, 13-33.
24. Osebold, J.W., Gershwin, L.J. and Zee, Y.C. (1980) Studies on the enhancement of allergic lung sensitization by inhalation of ozone and sulfuric acid aerosol. J. Environ. Pathol. Toxicol. 3, 221-234.
25. Pease, D.C. (1964) Histological Techniques for Electron Microscopy, Second Edition. Academic Press, New York, pp. 38-39.
26. Reiser, K.M. and Last, J.A. (1983) Analysis of collagen composition and biosynthesis by HPLC. Liq. Chromatogr. 1, 498-502.
27. Reiser, K.M. and Last, J.A. (1986) Collagen crosslinging in lungs of rats with experimental silicosis. Collagen Rel. Res. 6, 313-324.
28. Reiser, K.M., Tryka, A.F., Lindenschmidt, R.C., Last, J.A. and Witschi, H.R. (1986) Changes in collagen crosslinking in bleomycin-induced pulmonary fibrosis. J. Biochem. Toxicol. 1, 83-91.
29. Reiser, K.M., Tyler, W.S., Hennessy, S.M., Dominguez, J.J. and Last, J.A. (1987) Long-term consequences of exposure to ozone. II. Structural alterations in lung collagen of monkeys. Toxicol. Appl. Pharmacol. 89, 314-322.
30. Schlesinger, R.B., Naumann, B.D. and Chen, L.C. (1983) Physiological and histological alterations in the bronchial nucociliary clearance system of rabbits following intermittent oral or nasal inhalation of sulfuric acid mist. J. Toxicol. Environ. Health 12, 441-465.
31. Schlesinger, R.B. (1990) Exposure response pattern for sulfuric acid-induced effects on particle clearance from the respiratory region of rabbit lungs. Inhal. Toxicol. 2, 21-27.
32. Schwartz, L.W., Dungworth, D.L., Mustafa, M.G., Tarkington, B.K. and Tyler, W.S. (1976) Pulmonary responses of rats to ambient levels of ozone. Lab. Invest. 34, 565-572.
33. Schwartz, L.W., Moore, P.F., Chang, D.P., Tarkington, B.K., Dungworth, D.L. and Tyler, W.S. (1977) Short-term effects of sulfuric acid aerosols on the respiratory tract: a morphological study in guinea pigs, mice, rats, and monkeys. In: S.D. Lee and B. Peirano (Eds.), Biochemical Effects of Environmental Pollutants, Ann Arbor Science Publishers, Ann Arbor, pp. 257-271.
34. Snedecor, C.W. and Cochran, W.G. (1967) Statistical Methods. Iowa State University Press, Ames.
35. Stokinger, H.E., Wagner, W.D. and Dobrogorski, O.J. (1957) Ozone toxicity studies. III. Chronic injury to lungs of animals following exposure at a low level. Arch. Ind. Health 16, 514-522.
36. Vincent, R., Chang, L.Y., Mercer, R.R., Miller, F.J. and Crapo, J.D. (1989) Interstitial pulmonary fibrosis in rodents following chronic exposure to an ambient pattern of ozone. Am. Rev. Respir. Dis. 139, A278 (Abstract).
37. Warren, D.L. and Last, J.A. (1987) Synergistic interaction of ozone and respirable aerosols on rat lungs. III. Ozone and sulfuric acid aerosol. Toxicol. Appl. Pharmacol. 88, 203-216.
38. Werthamer, S., Penha, P.D. and Amaral, L. (1974) Pulmonary lesions induced by chronic exposure to ozone. Arch. Environ. Health 29, 164-166.
39. Woessner, Jr. J.F. (1961) The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch. Biochem. Biophys. 93, 440-447.