Regional lung deposition and clearance of 99mTc-labeled beclomethasone-DLPC liposomes in mild and severe asthma

Chest

Volumn 113, Issue 6, 1998, Pages 1573-1579

  Saari, S Marisanna ^a   Vidgren, Mika T ^c   Koskinen, Matti O ^a   Turjanmaa, Väinö M H ^a   Waldrep, J Clifford ^d   Nieminen, Markku M ^b  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

99mtechnetium; Aerosol; Asthma; Beclomethasone dipropionate (Bec); Corticosteroids; Dilauroylphosphatidylcholine (DLPC); Liposome; Nebulizer

Indexed keywords

BECLOMETASONE DIPROPIONATE; CORTICOSTEROID; DILAUROYLPHOSPHATIDYLCHOLINE; TECHNETIUM 99M;

ARTICLE; DISEASE SEVERITY; DRUG DISTRIBUTION; LUNG CLEARANCE; LUNG DEPOSIT; MUCOCILIARY CLEARANCE; NEBULIZATION; PRIORITY JOURNAL;

EID: 0031750244     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.113.6.1573     Document Type: Article

References (27)

1. Taylor KMG, Taylor G, Kellaway JM. The influence of liposomal encapsulation on sodium cromoglycate pharmacokinetics in man. Pharm Res 1989; 6:633-36
2. Meisner D, Pringle J. Liposomal pulmonary delivery. J Microencapsul 1989; 6:379-87
3. McCalden TA, Abra RM. Bronchodilator efficacy of liposome formulations of metaproterenol sulfate in the anesthetized guinea pig. J Liposome Res 1989; 1:211-22
4. Waldrep JC, Keyhani K, Black M, et al. Operating characteristics of 18 different continuous-flow jet nebulizers with beclomethasone dipropionate liposome aerosol. Chest 1994; 105:106-10
5. Knight CM, Gilbert CM, Waldrep JC, et al. Inhalation of a corticosteroid-liposome preparation by normal subjects causes no adverse effects. Am Rev Respir Dis 1994; 4:A220
6. 99mtechnetium labelled beclomethasone dipropionate dilauroylphosphatidylcholine liposome aerosol in normal volunteers. Int J Pharm 1995; 115:209-16
7. Waldrep JC, Gilbert BE, Knight BN, et al. Pulmonary delivery of beclomethasone liposome aerosol in volunteers. Chest 1997; 111:316-23
8. American Thoracic Society. Guidelines to the diagnosis and treatment of asthma. Am Rev Respir Dis 1987; 136:224-44
9. Waldrep JC, Scherer PW, Hess GD, et al. Nebulized glucocorticoids in liposomes: aerosol characteristics and human dose estimates. J Aerosol Med 1994; 7:135-44
10. Robbins PJ. Chromatography of technetium-radiopharmaceuticals - a practical guide. New York: Society of Nuclear Medicine, 1984
11. Nieminen MM, Holli H, Lahdensuo A, et al. Aerosol deposition in automatic dosimeter nebulization. Eur J Respir Dis 1987; 71:145-52
12. Nieminen MM, Lahdensuo A, Kellomäki, et al. Methacholine bronchial challenge using dosimeter with controlled tidal breathing. Thorax 1988; 43:896-900
13. Nieminen MM, Moilanen E, Nyholm J-E, et al. Platelet-activating factor impairs tracheobronchial transport and increases plasma leukotriene. Eur Respir J 1991; 4:561-70
14. Smaldone GC, Perry RJ, Bennett WD, et al. Interpretation of '24 hour lung retention' in studies of mucociliary clearance. J Aerosol Med 1988; 1:11-20
15. Smaldone GC, Walser L, Perry RJ, et al. Generation and administration of aerosols for medical and physiological research studies. J Aerosol Med 1989; 2:81-87
16. Macey DJ, Marshall R. Absolute quantitation of radiotracer uptake in the lungs using a gamma camera. J Nucl Med 1982; 23:731-35
17. Dahlström K, Larsson P. Lung deposition and systemic availability of budenoside inhaled as nebulized suspension from different nebulizers. Drug Res Days (Stockholm); December 1996; 10
18. Laube BL, Swift DL, Wagner HN, et al. The effect of bronchial obstruction on central airway deposition of a saline aerosol in patients with asthma. Am Rev Respir Dis 1986; 133:740-43
19. Chung KF, Jeyasingh K, Snashall PD. Influence of airway calibre on the intrapulmonary dose and distribution of inhaled aerosol in normal and asthmatic subjects. Eur Respir J 1988; 1:890-95
20. Bateman JRM, Pavia D, Sheahan NF, et al. Impaired tracheobroncial clearance in patients with mild stable asthma. Thorax 1983; 38:463-67
21. Pavia D, Bateman JRM, Sheahan NF, et al. Tracheobronchial mucociliary clearance in asthma: impairment during remission. Thorax 1985; 40:171-75
22. O'Riordan TG, Iacono A, Keenan RJ, et al. Delivery and distribution of aerosolized cyclosporine in lung allograft recipients. Am J Respir Crit Care Med 1995; 151:516-21
23. Farr SJ, Kellaway IW, Parry-Jones DR, et al. 99m-Technetium as a marker of liposomal deposition and clearance in the human lung. Int J Pharm 1985; 26:303-16
24. 99mTc-DTPA in the human respiratory tract. Int J Pharm 1994; 102:159-65
25. Foster WM, Langenbach EG, Bergofsky EH. Lung mucociliary clearance in man: interdependence of bronchial and trachea mucus transport velocities with lung clearance in bronchial asthma and healthy subjects. Ann Occup Hyg 1982; 26:227-44
26. Messina MS, O'Riordan TG, Smaldone GC. Changes in mucociliary clearance during acute exacerbation of asthma. Am Rev Respir Dis 1991; 143:993-97
27. O'Riordan TG, Zwang J, Smaldone GC. Mucociliary clearance in adult asthma. Am Rev Respir Dis 1992; 146:598-603