Insufficient TGF-β1 production inactivates the autocrine growth suppressive circuit in human ovarian cancer cell lines

Anticancer Research

Volumn 19, Issue 1 A, 1999, Pages 413-420

  Zeinoun, Ziad ^b   Teugels, Erik ^a   De Bleser, Pieter J ^a   Neyns, Bart ^a   Geerts, Albert ^a   De Greve, Jacques ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b NONE

Author keywords

Apoptosis; Growth inhibition; Ovarian cancer; Transforming growth factor

Indexed keywords

CYTOKINE; MESSENGER RNA; RECEPTOR SUBTYPE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; AUTOCRINE EFFECT; AUTORADIOGRAPHY; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; NORTHERN BLOTTING; OVARY CANCER; PRIORITY JOURNAL;

ACTIVIN RECEPTORS, TYPE I; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; OVARIAN NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED;

EID: 0032922737     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. MacKay SL, Yaswen LR, Tarnuzzer RW, Moldawer LL, Bland KI, Copeland EM 3rd, Schultz GS: Colon cancer cells that are not growth inhibited by TGF-beta lack functional type I and type II TGF-beta receptors. Ann Surg 221: 767-776, 1995.
2. Lyons RM, Gentry E, Purchio A, Moses H: Mechanism of Activation of Latent Recombinant Transforming Growth Factor ß1 by Plasmin. J Cell Biol 110: 1361-1367, 1990.
3. Franzen P, ten Dijke P, Ichijo H, Yamashita H, Schulz P, Heldin C-H, Miyazono K: Cloning of a TGFB type I receptor that forms a heteromeric complex with TGFB type II receptor. Cell 75: 681-692, 1993.
4. Lin HY, Wang X-F, Ng-Eaton H, Weinberg RA, Lodish HF: Expression Cloning of the TGF-ß Type II Receptor, a Functional Transmembrane Serine Threonine Kinase. Cell 68: 775-785, 1992.
5. Laiho M, Weis FMB, Massague J: Concomitant Loss of Transforming Growth Factor (TGF)-ß Receptor Types I and II in TGF-ß-resistant Cell Mutants Implicates both receptor Types in Signal Transduction. J Biol Chem 265: 18518-18524, 1990.
6. Wieser R, Wrana JL, Massague J: GS domain mutation that constitutively activates T beta R-I, the downstream signalling component in the TGF-beta receptor complex. EMBO J 14: 2199-2208, 1995.
7. Nogaard P, Spang-Thomson M, Poulsen HS: Expression and autoregulation of transforming growth factor B receptor mRNA in small-cell lung cancer cell lines. Br J Cancer 67: 1015-1021, 1995.
8. Liu O, Huang SS, San Huang J: Function of the type V transforming growth factor B receptor in transforming growth factor B-induced growth inhibition of mink lung epithelial cells. J Biol Them 272: 18891-18895, 1997.
9. Havriesky LJ, Hurteau JA, Whitaker RS, Elbendary A, Wu S, Rodriguez G, Bast RC, Berchuck A: Regulation of Apoptosis in Normal and Malignant Ovarian Epithelial Cells by Transforming Growth Factor B. Cancer Res 55: 944-948, 1995.
10. Berchuck A, Rodriguez G, Olt G, Boente M, Whitaker R, Arrick BA, Clarke-Pearson D, Bast RC Jr: Regulation of growth of normal ovarian epithelial cells and ovarian cancer cell lines by transforming growth factor-B. Am J Obstet Gynecol 166: 676-684, 1992.
11. Elbentlary A, Berchuck A, Davis P, Havrilesky L, Bast RC Jr, Iglehart JD, Marks JR: Transforming growth factor beta 1 can induce CIP/WAFI expression independent of the p53 pathway in ovarian cancer cells. Cell Growth Differ 5: 1301-1307, 1994.
12. Massagué J: The Transforming Growth Factor-ß Family. Annu Rev Cell Biol 6: 597-641, 1990.
13. Rosl F: A simple and rapid method for detection of apoptosis in human cells. Nucl Acids Res 20: 5243, 1992.
14. Mathieu C, Jozan S, Mazars P, Come MG, Moisand A, Valette A: Density-Dependent Induction of Apoptosis by Transforming Growth Factor-ß1 in a Human Ovarian Carcinoma Cell Line. Exp Cell Res 216: 13-20, 1995.
15. Mazars P, Barboule N, Baldin V, Vidal S, Ducommun B, Valette A: Effects of TGF-ß1 (transforming growth factor-ß1) on the cell cycle regulation of human breast adenocarcinoma (MCF-7) cells. FEBS letters 362: 295-300, 1995.
16. Martikainen P, Kyaprianou N, Isaacs JT: Effect of transforming growth factor-ß1 on proliferation and death of rat prostatic cells. Endocrinology, 127: 2963-2968, 1990.
17. Chaouchi N, Arvanitakis L, Auffredou MT, Blanchard DA, Vazquez A, Sharma S: Characterization of transforming growth factor-ß1 induced apoptosis in normal human B cells and lymphoma B cell lines. Oncogene 11: 1615-22, 1995.
18. Yaginuma Y, Westphal H: Abnormal structure and expression of p53 gene in human ovarian carcinoma cell lines. Cancer Res 52: 4196-4199, 1992.
19. Jozan S, Guerrin M, Mazars P, Dutaur M, Monsarrat B, Cheutin F, Bugat R, Martel P: Transformong growth factor ß1 (TGF-ß1) inhibits growth of a human ovarian carcinoma cell line (OVCCR1) and is expressed in human ovarian tumors. Int J Cancer 52: 766-770, 1992.
20. Schwarz LC, Wright JA, Gingras MC, Kondaiah P, Danielpour D, Pimentel M. Sporn MB, Greenberg AH: Aberrant TGF-ß production and regulation in metastatic malignancy. Growth Factors J: 115-127, 1990.
21. Inagaki M, Moustakas A, Lin HY, Lodish HF, Carr BI: Growth inhibition by transforming growth factor beta (TGF-beta) type I is restored in TGF-beta-resistant hepatoma cells after expression of TGF-beta receptor type II cDNA. Proc Natl Acad Sci USA 90: 5359-63, 1993.
22. Eppert K, Scherer SW, Ozcelik H, Prione R, Hoodless P, Kim H, Tsui L, Bapat B, Gallinger S, Andulis IL, Thomsen HG, Wrana JL, Atlisano L: MADR2 Maps to 18q21 and Encodes a TGFB-Regulated MAD-Related Protein That Is Functionally Mutated in Colorectal Carcinoma. Cell 86: 543-552, 1996.
23. Hahn SA, Schutte M, Hoque ATMS, Moskaluk CA, da Costa LT, Rozenblum E, Weinstein CL, Fischer A, Yeo CJ, Hruban R, Kern SE: DPC4, A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1 Science 271: 350-353, 1996.
24. Lagna G, Hata A, Hemmati-Brivanlou A, Massague J: Partnership between DPC4 and SMAD proteins in TGF-ß signalling pathways. Nature 383: 832-836, 1996.
25. Hannon G. Beach D: plS is a potential effector of TGF-ß-induced cell cycle arrest. Nature, Vol. 371: 257-260, 1995.
26. Polyak K, Kato JY, Solomon MJ, Sherr CJ, Massague J, Roberts JM, Koff A: p27Kip1, a cyclin-CDK inhibitor, links transforming growth factor-ß and contact inhibition to cell cycle arrest. Genes Dev 8: 9-22, 1994.
27. Markowitz S, Wang J, Myeroff L, Parsons R, Sun L, Lutterbaugh J, Fan RS, Zborowaska E, Kinzler KW, Vogelstein B: Inactivation of type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science 268: 1336-1338, 1995.
28. Garrigue-Antar L, Munoz-Antonia T, Antonia SJ, Gesmonde J, Vellucci VF, Reiss M: Missense Mutation of the Transforming Growth Factor ß Type II Receptor in Human Head and Neck Squamous Carcinoma Cells. Cancer Res 55: 3982-3987, 1995.
29. Munoz-Antonia T, Li X, Reiss M. Jackson R, Antonia S: A Mutation in the Transforming Growth Factor ß Type II Recceptor Gene Promoter Associated with Loss of Gene Expression. Cancer Res 56: 4831-4835, 1996.