Circulating interferon-γ- and interleukin-4-secreting cells in recurrent spontaneous abortions

American Journal of Reproductive Immunology

Volumn 41, Issue 4, 1999, Pages 257-263

  Palfi, Miodrag ^a   Jablonowska, Barbara ^b   Matthiesen, Leif ^b   Ernerudh, Jan ^b  

^a LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^b NONE

Author keywords

Cytokines; Interferon ; Interleukin 4; Pregnancy; Recurrent spontaneous abortion (RSA); Th1; Th2

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; INTERLEUKIN 4; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME IMMUNOASSAY; FEMALE; HELPER CELL; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; PREGNANCY; PREGNANCY TERMINATION; PRIMIGRAVIDA; PRIORITY JOURNAL; SECRETORY CELL; SPONTANEOUS ABORTION;

EID: 0032920183     PISSN: 10467408     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0897.1999.tb00436.x     Document Type: Article

References (20)

1. H2 phenomenon? Immunol Today 1993; 14:353-356.
2. Hill JA, Polgar K, Anderson D: T-helper 1-type immunity to trophoblast in women with recurrent spontaneous abortion. JAMA 1995; 273:1933-1941.
3. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL: Two types of murine helper T cell clone: I. Definition according to profiles of lymfokine activities and secreted proteins. J Immunol 1986; 136:2348-2357.
4. Powrie F, Coffman RL: Cytokine regulation of T-cell function: Potential for therapeutic intervention. Immunol Today 1993; 14:270-274.
5. H2 responses: A key role for the 'natural' immune response? Immunol Today 1992; 13:379-381.
6. Mosmann TR, Sad S: The expanding universe of T-cell subsets: Th1, Th2, and more. Immunol Today 1996; 17:138-145.
7. Romaanani S: The Th1/Th2 paradigm. Immunol Today 1997; 18:263-266.
8. Lin H, Mosmann TR, Guilbert L, Tuntipopipat S, Wegmann TG: Synthesis of T helper 2-type cytokines at the maternal-fetal interface. J Immunol 1993; 151:4562-4573.
9. Drake BL, Head JR: Murine trophoblast can be killed by lymphokine-activated killer cells. J Immunol 1989; 143:9-14.
10. Raghupathy R: Th1-type immunity is incompatible with successful pregnancy. Immunol Today 1997; 18:478-482.
11. Tangri S, Wegmann TG, Lin H, Raghupathy R: Maternal anti-placental reactivity in natural immunologically mediated fetal resorptions. J Immunol 1994; 152:4903-4911.
12. Ekerfelt C, Matthiesen L, Berg G, Ernerudh J: Paternal leukocytes selectively increase secretion of IL-4 in periferal blood during normal pregnancies: Demonstrated by a novel one-way MLC-measuring cyokine secretion. Am J Reprod Immunol 1997; 38:320-327.
13. Matthiesen L, Ekerfelt C, Berg G, Ernerudh J: Increased numbers of circulating interferon-γ and interleukin-4 secreting cells during normal pregnancy. Am J Reprod Immunol 1998; 39:362-370.
14. Böyum A: Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest 1968; 21:77-79.
15. Czerkinsky C, Tarkowski A, Nilsson L-Å, Outcherlony Ö, Nygren H, Gretzer C: Reverse enzyme-linked immunospot (RELISPOT) assay for detection of cells secreting immunoreactive substances. J Immunol Methods 1984; 72:489-496.
16. Martzi M, Vigano A, Trabattoni D, Villa ML, Salvaggio A, Clerici E, Clerici M: Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic pregnancy. Clin Exp Immunol 1996; 106:127-133.
17. Jones CA, Finlay-Jones JJ, Hart PH: Type-1 and type-2 cytokines in human late-gestation decidual tissue. Biol Reprod 1997; 57:303-311.
18. Muraille E, Leo O: Revisiting the Th1/Th2 paradigm. Scand J Immunol 1998; 47:1-9.
19. Dudley DJ: Recurrent pregnancy loss and cytokines: Not as simple as it seems. JAMA 1995; 273:1958-1959.
20. Deneys V, De Bruyere M: Immunological tolerance of the fetal allograft: Efficacy of immunotherapy and IL-4 and TNFα serum levels in recurrent abortion. Transpl Proc 1997; 29:2467-2469.