Mechanisms of α-latrotoxin action

Cell and Tissue Research

Volumn 296, Issue 2, 1999, Pages 229-233

  Henkel, Andreas W ^a   Sankaranarayanan, Sethuraman ^a  

^a MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

Author keywords

Black widow spider venom; Calcium independent receptor for latrotoxin; Chromaffin cells; Exocytosis; G proteins; Latrophilin; Neurexins

Indexed keywords

ALPHA LATROTOXIN; CALCIUM ION; LATROPHILIN; MEMBRANE RECEPTOR; NEUREXIN; SPIDER VENOM; SYNAPTOTAGMIN; UNCLASSIFIED DRUG;

CALCIUM TRANSPORT; EXOCYTOSIS; MEMBRANE CHANNEL; NEUROSECRETORY CELL; NEUROTOXICITY; PRIORITY JOURNAL; SHORT SURVEY;

ANIMALS; BLACK WIDOW SPIDER; CALCIUM; CALCIUM CHANNELS; EXOCYTOSIS; MODELS, BIOLOGICAL; NERVE TISSUE PROTEINS; RECEPTORS, PEPTIDE; SPIDER VENOMS;

ARANEAE; LATRODECTUS TREDECIMGUTTATUS;

EID: 0032918324     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004410051284     Document Type: Short Survey

References (29)

1. 2+. Pflügers Arch 432:1039-1046
2. Capogna M, Gähwiler BH, Thompson SM (1996) Calcium-independent actions of α-latrotoxin on spontaneous and evoked synaptic transmission in the hippocampus. J Neurophysiol. 76:3149-3158
3. 2+-free solutions on the structure of the active zone. J Cell Biol 81:163-177
4. Davletov BA, Krasnoperov V, Hata Y, Petrenko AG, Südhof TC (1995) High affinity binding of alpha-latrotoxin to recombinant neurexin 1-alpha. J Biol Chem 270:23903-23905
5. 2+-independent alpha-latrotoxin-binding protein. J Biol Chem 271:23239-23245
6. Finkelstein A, Rubin LL, Tzeng MC (1976) Black widow spider venom: effect of purified toxin on lipid bilayer membranes. Science 193:1009-1011
7. 2+ sensor for transmitter release at a central synapse. Cell 79:717-727
8. Geppert M, Khvotchev M, Krasnoperov V, Goda Y, Missler M, Hammer RE, Ichtchenko K, Petrenko AG, Südhof TC (1998) Neurexin 1-alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action. J Biol Chem 273:1705-1710
9. Gorio A, Hurlbut WP, Ceccarelli B (1978) Acetylcholine compartments in mouse diaphragm. Comparison of the effects of black widow spider venom, electrical stimulation, and high concentrations of potassium. J Cell Biol 78:716-733
10. Hata Y, Butz S, Südhof TC (1996) Cask - a novel dlg/psd95 homolog with an n-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins. J Neurosci 16:2488-2494
11. Henkel AW, Betz WJ (1995) Visualization of black widow spider venom induced exo- and endocytosis at the frog neuromuscular junction with FM1-43. Neuropharmacology 34:1397-1406
12. Hurlbut WP, Chieregatti E, Valtorta F, Haimann C (1994) α-Latrotoxin channels in neuroblastoma cells. J Memb Biol 138:91-102
13. Krasnoperov VG, Beavis R, Chepurny OG, Little AR, Plotnikov AN, Petrenko AG (1996) The calcium-independent receptor of alpha-latrotoxin is not a neurexin. Biochem Biophys Res Comm 227:868-875
14. Krasnoperov VG, Bittner MA, Beavis R, Kuang YN, Salnikow KV, Chepurny OG, Little AR, Plotnikov AN, Wu DQ, Holz RW, Petrenko AG (1997) Alpha-latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor. Neuron 18:925-937
15. 2+-independent insulin exocytosis induced by alpha-latrotoxin requires latrophilin, a G-protein-coupled receptor. EMBO J 17: 648-657
16. Lelianova VG, Davletov BA, Sterling A, Rahman MA, Grishin EV, Totty NF, Ushkaryov YA (1997) Alpha-latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptors. J Biol Chem 72:21504-21508
17. Liu J, Misler S (1998) α-Latrotoxin alters spontaneous and depolarization-evoked quantal release from rat adrenal chromaffin cells: evidence for multiple modes of action. J Neurosci 18:6113-6125
18. 2+ and neurotransmitter release: studies on PC12 cells and synaptosomes exposed to alpha-latrotoxin. Proc Natl Acad Sci U S A 81:620-624
19. 2+ entry or [Ca+](i). J Physiol Lond 502: 481-496
20. Missler M, Südhof TC (1998a) Neurexins - three genes and 1001 products. Trends Genetics 14:20-26
21. Missler M, Südhof TC (1998b) Neurexophilins form a conserved family of neuropeptide-like glycoproteins. J Neurosci 18:3630-3638
22. 2+ influx and stimulated neurotransmitter release. Neuroscience 56:695-701
23. Petrenko AG, Kovalenko VA, Shamotienko OG, Surkova IN, Tarasyuk TA, Ushkaryov YA, Grishin EV (1990) Isolation and properties of the α-latrotoxin receptor. EMBO J 9:2023-2027
24. Petrenko AG, Perin MS, Davletov BA, Ushkaryov YA, Geppert M, Südhof TC (1991) Binding of synaptotagmin to the alpha-latrotoxin receptor implicates both in synaptic vesicle exocytosis. Nature 353:65-68
25. Petrenko AG, Ullrich B, Missler M, Krasnoperov V, Rosahl TW, Südhof TC (1996) Structure and evolution of neurexophilin. J Neurosci 16:4360-4369
26. Rosenthal L, Meldolesi J (1989) Alpha-latrotoxin and related toxins. Pharmacol Ther 42:115-134
27. Ullrich B, Ushkaryov YA, Südhof TC (1995) Cartography of neurexins - more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons. Neuron 14:497-507
28. Ushkaryov YA, Petrenko AG, Geppert M, Südhof TC (1992) Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin. Science 257:50-56
29. Volkova TM, Pluzhnikov KA, Woll PG, Grishin EV (1995) Low molecular weight components from black widow spider venom. Toxicon 33:483-489