Regional heterogeneity in the brain's response to hypoxia measured using BOLD MR imaging

Magnetic Resonance in Medicine

Volumn 41, Issue 4, 1999, Pages 850-854

  Dunn, Jeff F ^a,d   Zaim Wadghiri, Y ^b   Meyerand, M E ^c  

^a DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

Brain; FMRI; Hippocampus; Hypoxia; MR imaging

Indexed keywords

BRAIN; MAGNETIC RESONANCE IMAGING; OXYGENATION;

BLOOD OXYGENATION LEVEL DEPENDENT; BRAIN REGIONS; DEOXYHEMOGLOBIN; FMRI; GRADIENT ECHO SEQUENCES; HIPPOCAMPUS; HYPOXIA; MR IMAGING;

MAGNETIC RESONANCE;

DEOXYHEMOGLOBIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD OXYGENATION; BRAIN HYPOXIA; BRAIN REGION; COGNITION; HIPPOCAMPUS; MEMORY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; RAT;

EID: 0032916170     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1522-2594(199904)41:4<850::AID-MRM27>3.0.CO;2-L     Document Type: Article

References (44)

1. Pauling L, Coryell CD. The magnetic properties and structure of hemoglobin, oxyhemoglobin and carbonmonoxyhemoglobin. Proc Natl Acad Sci USA 1936;22:210.
2. Thulborn K, Waterton J, Mathews P, Radda G. Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field. Biochim Biophys Acta 1982;714:265-270.
3. Dunn JF, Swartz HM. Blood oxygenation: heterogeneity of hypoxic tissues monitored using bold MR imaging. Adv Exp Med Biol 1996;428: 645-650.
4. Brooks RA, Brunetti A, Alger JR, Di Chiro G. On the origin of paramagnetic inhomogeneity effects in blood. Magn Reson Med 1989;12: 241-248.
5. Turner R, Le Bihan D, Moonen CT, Despres D, Frank J. Echo-planar time course MRI of cat brain oxygenation changes. Magn Reson Med 1991;22:159-66.
6. Ogawa S, Lee TM, Kay AR, Tank DW. Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci USA 1990;87:9868-9872.
7. Ogawa S, Lee T-M, Nayak A, Glynn P. Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn Reson Med 1990;14:68-78.
8. Bandettini PA, Wong EC, Hinks RS, Tikofsky RS, Hyde JS. Time course EPI of human brain function during task activation. Magn Reson Med 1992;25:390-397.
9. Lin W, Paczynski RP, Celik A, Kuppusamy K, Hsu CY, Powers WJ. Experimental hypoxemic hypoxia: changes in R2* of brain parenchyma accurately reflect the combined effects of changes in arterial and cerebral venous oxygen saturation. Magn Reson Med 1998;39:474-481.
10. Ogawa S, Tank DW, Menon R, Ellermann JM, Kim SG, Merkle H, Ugurbil K. Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci USA 1992;89:5951-5955.
11. Menon RS, Ogawa S, Kim SG, Ellermann JM, Merkle H, Tank DW, Ugurbil K. Functional brain mapping using magnetic resonance imaging. Signal changes accompanying visual stimulation. Invest Radiol 1992;27(Suppl 2):S47-53.
12. Kwong KK, Belliveau JW, Chesler DA, Goldberg IE, Weisskoff RM, Poncelet BP, Kennedy DN, Hoppel BE, Cohen MS, Turner R, Cheng H, Brady TJ, Rosen BJ. Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci USA 1992;89:5675-5679.
13. Frahm J, Bruhn H, Merboldt K-D, Hanicke W. Dynamic MR imaging of human brain oxygenation during rest and photic stimulation. J Magn Reson Imaging 1992;2:501-505.
14. Blamire AM, Ogawa S, Ugurbil K, Rothman D, McCarthy G, Ellermann JM, et al. Dynamic mapping of the human visual cortex by high-speed magnetic resonance imaging. Proc Natl Acad Sci USA 1992;89:11069-11073.
15. Ogawa S, Menon RS, Tank DW, Kim SG, Merkle H, Eilermann JM, Ugurbil K. Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model. Biophys J 1993;64:803-812.
16. Gati JS, Menon RS, Ugurbil K, Rutt BK. Experimental determination of the BOLD field strength dependence in vessels and tissue. Magn Reson Med 1997;38:296-302.
17. Chen W, Zhu X-H, Kato T, Anderson P, Ugurbil K. Spatial and temporal differentiation of fMRI BOLD response in primary visual cortex of human brain during sustained visual stimulation. Magn Reson Med 1998;39:520-527.
18. Frahm J, Klaus-Dietmar M, Hanicke W, Kleinschmidt A, Boecker H. Brain or vein - oxygenation or flow? On signal physiology in functional MRI of human brain activation. NMR Biomed 1994;7:45-53.
19. Hoppel BE, Weisskoff RM, Thulborn KR, Moore JB, Kwong KK, Rosen BR. Measurement of regional blood oxygenation and cerebral hemodynamics. Magn Reson Med 1993;30:715-723.
20. Kida I, Yamamoto T, Tamura M. Interpretation of BOLD MRI signals in rat brain using simultaneously measured near-infrared spectrophotometric information. NMR Biomed 1996;9:333-338.
21. Prielmeier F, Nagatomo Y, Frahm J. Cerebral blood oxygenation in rat brain during hypoxic hypoxia. Quantitative MRI of effective transverse relaxation rates. Magn Reson Med 1994;31:678-681.
22. Stehling MK, Schmitt F, Ladebeck R. Echo-planar MR imaging of human brain oxygenation changes. J Magn Reson Imaging 1993;3:471-474.
23. Freund TF, Buzsaki G, Prohaska OJ, Somogyi P. Simultaneous recording of local electrical activity, partial oxygen tension and temperature in the rat hippocampus with a chamber-type microelectrode. Effects of anesthesia, ischemia and epilepsy. Neuroscience 1989;28:539-549.
24. Zola-Morgan S, Squire LR, Amaral DG. Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to the field CA1 of the hippocampus. J Neurosci 1986;6:2950-2967.
25. Stern CE, Corkin S, Gonzalez RG, Guimaraes AR, Baker JR, Jennings PJ, Carr CA, Sugiura RM, Vedantham V, Rosen BR. The hippocampal formation participates in novel picture encoding: evidence from functional magnetic resonance imaging. Proc Natl Acad Sci USA 1996;93: 8660-8665.
26. Lowenstein DH. Recent advances related to basic mechanisms of epileptogenesis. Epilepsy Res 1996;suppl 11:45-60.
27. Coyle P. Spatial features of the rat hippocampal vascular system. Exp Neurol 1978;58:549-561.
28. Prielmeier F, Merboldt KD, Hanicke W, Frahm J. Dynamic high-resolution MR imaging of brain deoxygenation during transient anoxia in the anesthetized rat. J Cereb Blood Flow Metab 1993;13:889-894.
29. Jones R, Muller T, Haraldseth O, Baptista A, Oksendal A. Cerebrovascular changes in rats during ischemia and reperfusion: a comparison of BOLD and first pass bolus tracking techniques. Magn Reson Med 1996;35:489-496.
30. Rostrup E, Larsson HBW, Toft PB, Garde K, Henriksen O. Signal changes in gradient echo images of human brain induced by hypo- and hyperoxia. NMR Biomed 1995;8:41-47.
31. Ding S, Azzawi A, Alpern N, Rolett EL, Weaver JB, Dunn JF. EPI at 7 Tesla: imaging of blood oxygen changes during hypoxia in a rat brain. In: Proceedings of the Society of Magnetic Resonance, Nice, 1995. p 861.
32. Ding S, Rolett EL, Weaver JB, Dunn JF. Monitoring regional variation in cerebral microvascular response to hypoxia in rat using EPI at 7T. In: Proceedings of the Society of Magnetic Resonance, New York, 1996. p 524.
33. Klein B, Kuschinsky W, Schrock H, Vetterlein F. Interdependency of local capillary density, blood flow, and metabolism in rat brains. Am J Physiol 1986;251:H1333-H1340.
34. Cremillieux Y, Ding S, Dunn JF. High resolution in vivo measurements of transverse relaxation times in rats at 7 Tesla. Magn Reson Med 1997;39:285-290.
35. Jezzard P, Heineman F, Taylor J, DesPres D, Wen H, Balaban RS, Turner R. Comparison of EPI gradient-echo contrast changes in cat brain caused by respiratory challenges with direct simultaneous evaluation of cerebral oxygenation via a cranial window. NMR Biomed 1994;7:35-44.
36. Ogawa S, Lee TM, Barrere B. The sensitivity of magnetic resonance image signals of a rat brain to changes in the cerebral venous blood oxygenation. Magn Reson Med 1993;29:205-210.
37. Ordidge RJ, Punwani S, Cooper C, Clemence M, Amess P, Penrice J, Thronton J. Correlation between absolute [dHb] as measured by near infrared spectroscopy (NIRS) and absolute R2* as determined by MRI. In: Proceedings of the International Society of Magnetic Resonance in Medicine, Vancouver, 1997. p 157.
38. Hudetz AG, Conger KA, Pal M, Horton CR. Mathematical analysis of network topology in the cerebrocortical microvasculature. Adv Exp Med Biol 1987;222:87-94.
39. Bereczki D, Wei L, Otsuka T, Acuff V, Pettigrew K, Patlak C, Fenstermacher J. Hypoxia increases velocity of blood flow through parenchymal microvascular systems in rat brain. J Cereb Blood Flow Metab 1993;13: 475-486.
40. Blinkov SM, Glezer II. New York: Plenum Press; 1968.
41. Gesztelyi G, Finnegan W, DeMaro JA, Wang JY, Chen JL. Fenstermacher J. Parenchymal microvascular systems and cerebral atrophy in spontaneously hypertensive rats. Brain Res 1993;611:249-257.
42. Petito CK, Feldman E, Pulsinelli WA, Plum F. Delayed hippocampal damage in humans following cardiorespiratory arrest. Neurology 1987; 37:1281-1286.
43. Horn M, Scholte W. Delayed neuronal death and delayed neuronal recovery in the human brain following global ischemia. Acta Neuropathol 1992;85:79-87.
44. Buxton RB, Wong EC, Frank LR. Dynamics of blood flow and oxygenation changes during brain activation: the balloon model. Magn Reson Med 1998;39:855-864.