An in vitro model for the Allergen-IgE-FcεRI interaction

International Archives of Allergy and Immunology

Volumn 118, Issue 2-4, 1999, Pages 116-118

  Laffer, Sylvia ^a   Hogbom, Erik ^c   Adrianson, Jonas ^c   Grönlund, Hans ^c   Sillaber, Christian ^a   Valent, Peter ^a   Vangelista, Luca ^d   Kricek, Franz ^b   Kraft, Dietrich ^a   Valenta, Rudolf ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b Novartis Research Center   (Austria)

^c PFIZER INC   (United States)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

rBet v 1; rBet v 1 specific chimeric IgE; Recombinant allergen; Recombinant Fc receptor alpha chain; Type 1 allergy

Indexed keywords

ALLERGEN; CHIMERIC ANTIBODY; FC RECEPTOR; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MONOCLONAL ANTIBODY; POLLEN ANTIGEN; PYROXYLIN; RECOMBINANT RECEPTOR;

ALPHA CHAIN; BACULOVIRUS; BASOPHIL; CONFERENCE PAPER; HUMAN; IMMEDIATE TYPE HYPERSENSITIVITY; IN VITRO STUDY; MAST CELL; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYMPTOM; T LYMPHOCYTE ACTIVATION;

EID: 0032915219     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000024044     Document Type: Conference Paper

References (18)

1. Kay AB: Allergy and Allergic Diseases. Oxford, Blackwell, 1997.
2. Lichtenstein LM, Osler AG: Studies on the mechanism of hypersensitivity phenomena. IX. Histamine release from human leukocytes by ragweed pollen antigen. J Exp Med 1964; 120:507.
3. Mudde GC, Van-Reijsen FC, Boland GJ, de Gast GC, Bruijnzeel PL, Bruijnzeel-Koomen CA: Allergen presentation by epidermal Langerhans cells from patients with atopic dermatitis is mediated by IgE. Immunology 1990; 69:335-341.
4. Maurer D, Ebner C, Reininger B, Fiebiger E, Kraft D, Kinet JP, Stingl G: The high-affinity IgE receptor (Fc epsilon RI) mediates IgE-dependent allergen presentation. J Immunol 1995;154:6285-6290.
5. Maurer D, Fiebiger S, Ebner C, Reininger B, Fischer GF. Wichlas S, Jouvin MH, Schmitt-Egenolf M, Kraft D, Kinet JP, Stingl G: Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI aloha- and Fc epsilon RI gamma-chains and can use this receptor for IgE-mediated allergen presentation. J Immunol 1996;157:607-616.
6. Stingl G, Maurer D: IgE-mediated allergen presentation via Fc epsilon RI on antigen-presenting cells. Int Arch Allergy Immunol 1997;113:24-29.
7. Helm B, Marsh P, Vercelli D, Padlan E, Gould H, Geha R: The mast cell binding site on human immunoglobulin E. Nature 1988;331: 180-183.
8. Presta L, Shields R, O'Connell L, Lahr S, Porter J, Gorman C, Jardieu P: The binding site on human immunoglobulin E for its high affinity receptor. J Biol Chem 1994;269: 26368-26373.
9. Helm B, Sayers I, Higginbottom A. Cantarelli Machado D, Ling Y, Ahmad K, Padlan EA, Wilson APM: Identification of the high affinity receptor binding region in human immunoglobulin E. J Biol Chem 1996;271:7494-7500.
10. Hamburger RN: Peptide inhibition of the Prausnitz-Küstner reaction. Science 1975;189: 389-390.
11. McDonell JM, Beavil AJ, Mackay GA, Jameson BA, Korngold R, Gould HJ, Sutton BJ: Structure based design and characterisation of peptides that inhibit IgE binding to its high-affinity receptor. Nat Struct Biol 1996;3:419-426.
12. Hellman L: Profound reduction in allergen sensitivity following treatment with a novel allergy vaccine. Eur J Immunol 1994;24:415-420.
13. Presta LG, Lahr SJ, Shields RL, Porter JP, Gorman CM, Fendly BM, Jardieu PM: Humanization of an antibody directed against IgE. J Immunol 1993;151:2623-2632.
14. Holgate ST, Corne J, Jardieu P, Pick RB, Heusser CH: Treatment of allergic airways disease with anti-IgE; in: Allergy: 30 Years with IgE. Copenhagen, Munksgaard, 1998, vol 45, pp 91-96.
15. Breiteneder H. Pettenburger K, Bito A, Valenta R, Kraft D, Rumpold H, Scheiner O, Breitenbach M: The gene coding for the major birch pollen allergen Bet v 1, is highly homologous to a pea disease resistance response gene. EMBO J 1989;8:1935-1938.
16. Jarolim E, Tejkl M, Rohac M, Schlerka G, Scheiner O, Kraft D, Breitenbach M, Rumpold H: Monoclonal antibodies against birch pollen allergens: Characterization by immunoblotting and use for sinlge-step affinity purification of the major birch pollen allergen Bet v 1. Int Arch Allergy Immunol 1989;90:54-60
17. Laffer S, Vangelista L, Steinberger P, Kraft D, Pastore A, Valenta R: Molecular characterization of Bip 1, a monoclonal antibody that modulates IgE binding to birch pollen allergen, Bet v 1. J Immunol 1996;157:4953-4962.
18. Kochan J, Pettine LF, Hakimi J, Kishi K, Kinet JP: Isolation of the gene coding for the alpha subunit of the human high affinity IgE receptor. Nucleic Acids Res 1988;16:3584.