Cytoplasmic lipid bodies in eosinophils: Central roles in eicosanoid generation

International Archives of Allergy and Immunology

Volumn 118, Issue 2-4, 1999, Pages 450-452

  Weller, Peter F ^a,b   Bozza, Patricia T ^a   Yu, Wengui ^a   Dvorak, Ann M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Arachidonic acid; Eicosanoids; Eosinophils; Leukotriene C4; Lipid bodies; Priming

Indexed keywords

ARACHIDONIC ACID; CALCIUM IONOPHORE; DIACYLGLYCEROL; ICOSANOID; LEUKOTRIENE C4; OLEIC ACID; THROMBOCYTE ACTIVATING FACTOR;

ARACHIDONIC ACID METABOLISM; CONFERENCE PAPER; EOSINOPHIL; HUMAN; HUMAN CELL; ICOSANOID METABOLISM; IMMUNOASSAY; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0032914188     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000024161     Document Type: Conference Paper

References (12)

1. Weller PF, Monahan-Early RA, Dvorak HF, Dvorak AM: Cytoplasmic lipid bodies of human eosinophils: Subcellular isolation and analysis of arachidonate incorporation. Am J Pathol 1991;138:141-148.
2. Solley GO, Maldonado JE, Gleich GJ, Giulani ER, Hoagland HC, Pierre RV, Brown AL Jr: Endomyocardiopathy with eosinophilia. Mayo Clin Proc 1976;51:697-708.
3. Beil WJ, Weller PF, Peppercorn MA, Dvorak AM: Ultrastructural immunogol localization of subcellular sites of TNF-α in colonic Crohn's disease. J Leukocyte Biol 1995;58: 284-298.
4. Weller PF, Ackerman SJ, Nicholson-Weller A, Dvorak AM: Cytoplasmic lipid bodies of human neutrophilic leukocytes. Am J Pathol 1989;135:947-959.
5. Bozza PT, Yu W, Penrose JF, Morgan ES, Dvorak AM, Weller PF, Eosinophil lipid bodies: Specific, inducible intracellular sites for enhanced eicosanoid formation. J Exp Med 1997;186:909-920.
6. 2 at cytoplasmic lipid bodies of U937 cells. Am J Pathol 1998;152:759-769.
7. Dvorak AM, Morgan E, Tzizik DM, Weller PF: Prostaglandin endoperoxide synthase (cyclooxygenase): Ultrastructural localization to nonmembrane-bound cytoplasmid lipid bodies in human eosinophils and murine 3T3 fibroblasts. Int Arch Allergy Immunol 1994;105: 245-250.
8. Dvorak AM, Morgan E, Schleimer RP, Ryeom SW, Lichtenstein LM, Weller PF: Ultrastructural immunogold localization of prostaglandin endoperoxide synthase (cyclooxygenase) to nonmembrane-bound cytoplasmic lipid bodies in humn lungs mast cells, alveolar macrophages, type II pneumocytes and neutrophils. J Histochem Cytochem 1992;40:759-769.
9. Dvorak AM, Schleimer RP, Dvorak AM, Lichtenstein LM, Weller PF: Human lung mast cell and alveolar macrophage cytoplasmic lipid bodies contain arachidonic acid and prostaglandin endoperoxide synthase (cyclooxygenase), the substrate and enzyme necessary for prostaglandin production. Int Arch Allergy Immunol 1992;99:208-217.
10. Bozza PT, Payne JL, Morham SG, Langenbach R, Smithies O, Weller PF: Leukocyte lipid body formation and eicosanoid generation: Cyclooxygenase-independent inhibition by aspirin. Proc Natl Acad Sci USA 1996;93: 11091-11096.
11. Bozza PT, Payne JL, Goulet JL, Weller PF: Mechanisms of PAF-induced lipid body formation: A central role for 5-lipoxygenase in the compartmentalization of leukocyte lipids. J Exp Med 1996;183:1515-1525.
12. Weller PF, Ryeom SW, Picard ST, Ackerman SJ, Dvorak AM: Cytoplasmic lipid bodies of neutrophils: Formation induced by cis-unsaturated fatty acids and mediated by protein kinase C. J Cell Biol 1991;113:137-146.