Suppression of Epstein-Barr virus reactivation in lymphoblastoid cells cultured in simulated microgravity

In Vitro Cellular and Developmental Biology - Animal

Volumn 35, Issue 1, 1999, Pages 49-54

  Long, James P ^a   Pierson, Sandrine ^b   Hughes, John H ^b  

^a OHIO STATE UNIVERSITY   (United States)

^b NATIONWIDE CHILDREN S HOSPITAL   (United States)

Author keywords

Cell biology; Latency; NASA; Rotating wall vessel; Virology

Indexed keywords

ARTICLE; CELL CULTURE; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LYMPHOBLASTOID CELL; MICROGRAVITY; NONHUMAN; RNA ANALYSIS; VIRUS REACTIVATION;

HUMAN HERPESVIRUS 4; MIRIDAE;

EID: 0032911581     PISSN: 10712690     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11626-999-0043-3     Document Type: Article

References (22)

1. Bechler, B.; Hunzinger, E.; Muller, O.; Cogoli, A. Culture of hybridoma and friend leukemia virus transformed cells in microgravity. Spacelab IML-1 mission. Biol. Cell 79:45-50; 1993.
2. Becker, J. L.; Prewett, T. L.; Spaulding, G. F.; Goodwin, T. J. Three dimensional growth and differentiation of ovarian tumor cell line in high aspect rotating-wall vessel: morphologic and embryologic considerations. J. Cell. Biochem. 51:283-289; 1993.
3. Cogoli, A. The effect of hypogravity and hypergravity on cells of the immune system. J. Leukocyte Biol. 54:259-268; 1993.
4. Cogoli, M. The fast rotating clinostat: a history of its use in gravitational biology and a comparison of ground-based and flight experiment results. American Society for Gravitational and Space Biology Bull. 5:59-67; 1992.
5. Countryman, J.; Jenson, H.; Seibl, R.; Wolf, H.; Miller, G. Polymorphic proteins encoded within BZLF1 of defective and standard Epstein-Barr viruses disrupt latency. J. Virol. 61:3672-3679; 1987.
6. Countryman, J.; Miller, G. Activation of expression of latent Epstein-Barr herpesvirus after gene transfer with a small cloned subfragment of heterogenous viral DNA. Proc. Natl. Acad. Sci. USA 82:4085-1089; 1985.
7. Fries, K. L.; Sculley, T. B.; Webster-Cyriaque, J.; Rajadurai, K; Sadler, R. H.; Raab-Traub, N. Identification of a novel protein encoded by the Bam HI A region of the Epstein-Barr Virus. J. Virol. 71:2765-2771; 1997.
8. Goodwin, T. J.; Prewitt, T. L.; Wolf, D. A.; Spaulding, G. F. Reduced shear stress: a major component in the ability of mammalian tissues to form three-dimensional assemblies in simulated microgravity. J. Cell. Biochem. 51:301-311; 1993.
9. Jessup, J. M.; Goodwill T. J.; Spaulding, G. Prospects for use of microgravity-based bioreactors to study three-dimensional host-tumor interactions in human neoplasia. J. Cell. Biochem. 51:290-300; 1993.
10. Kolman, J. L.; Taylor, N.; Gradoville, L.; Countryman, J.; Miller, G. Comparing transcriptional activation and autostimulation by ZEBRA and ZEBRA/c-Fos chimeras. J. Virol. 70:1493-1504; 1996.
11. Long, J. P.; Pierson, S.; Hughes, J. H. Rhinovirus replication in HeLa cells cultured under conditions of simulated microgravity. Aviat. Space Environ. Med. 69:851-856; 1998.
12. Montalvo, E. A.; Cottam, M.; Hill, S.; Wang, Y.-C. J. YY1 binds to and regulates cis-acting negative elements in the Epstein-Barr virus BZLF1 promoter. J. Virol. 69:4158-4165; 1995.
13. Morrison, D. R.; Chapes, S. K.; Guikema, J. A.; Spooner, B. S.; Lewis, M. L. Experiments with suspended cells on the space shuttle [Review]. Physiologist 35:S31-34; 1992.
14. Rawlins, D. R.; Milman, G.; Hayward, S. D.; Hayward, G. S. Sequence-specific DNA binding of the Epstein-Barr virus nuclear antigen (EBNA-1) to clustered sites in the plasmid maintenance region. Cell 42:859-868; 1985.
15. Rowe, M.; Rowe, D. T.; Gregory, C. D.; Young, L. S.; Farrell, P. J.; Rupani, H.; Rickinson, A. B. Differences in B-cell growth phenotype reflect novel patterns of Epstein-Barr virus latent gene expression in Burkitt's lymphoma cells. EMBO J. 6:2743-2751; 1987.
16. Schwarz, R. P.; Goodwin, T. J.; Wolf, D. A. Cell culture for three-dimensional modeling in rotating-wall vessels: an application of simulated microgravity. J. Tissue Cult. Methods 14:51-58; 1992.
17. Spaulding, G. F; Jessup, J. M.; Goodwin, T. J. Advances in cellular construction. J. Cell. Biochem. 51:249-251; 1993.
18. Speck, S. H.; Strominger, J. L. Transcription of Epstein-Barr virus in latently infected, growth-transformed lymphocytes. Adv. Viral Oncol. 8:133-150; 1989.
19. Synthecon Inc. Rotary Cell Culture Systems Bulletin. Houston, TX; 1995.
20. Tierney, R. J.; Steven, N.; Young, L. S.; Rickinson, A. B. Epstein-Barr virus latency in blood mononuclear cells: analysis of viral gene transcription during primary infection and in the carrier state. J. Virol. 68:7374-7385; 1994.
21. Wang, Y.-C. J.; Huang, J.-M.; Montalvo, E. A. Characterization of proteins binding to the ZII element in the Epstein-Barr virus BZLF1 promoter: transactivation by ATF1. Virology 227:323-330; 1997.
22. Yates, J. L.; Warren, N.; Sugden, B. Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells. Nature 313:812-815; 1985.