The role of somatic hypermutation in the generation of deletions and duplications in human Ig V region genes and chromosomal translocations

Current Topics in Microbiology and Immunology

Volumn 246, Issue , 1999, Pages 193-198

  Kuppers R ^a   Goossens, T ^a   Klein, U ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

B CELL LYMPHOMA; CHROMOSOME TRANSLOCATION; CONFERENCE PAPER; GENE DELETION; GENE DUPLICATION; GENE MUTATION; GENE REARRANGEMENT; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

EID: 0032909060     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-60162-0_24     Document Type: Conference Paper

References (10)

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2. Rajewsky K (1996) Clonal selection and learning in the antibody system. Nature 381:751-758
3. Neuberger MS, Milstein C (1995) Somatic hypermutation. Curr Opin Immunol 7:248-254
4. Goossens T, Klein U, Küppers R (1998) Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease. Proc Natl Acad Sci USA 95:2463-2468
5. Fischer M, Küppers R (1998) Human IgA- and IgM-secreting intestinal plasma cells carry heavily mutated VH region genes. Eur J Immunol 28:2971-2977
6. + peripheral blood B-cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B-cells. J Exp Med 188:1679-1689
7. Wilson PC, de Bouteiller O, Liu Y-J, Potter K, Banchereau J, Capra J D, Pascual V (1998) Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes. J Exp Med 187:59-70
8. Ohlin M, Borrebaeck CAK (1998) Insertions and deletions in hypervariable loops of antibody heavy chains contribute to molecular diversity. Mol Immunol 35:233-238
9. Levy Y, Gupta N, Le Deist F, Garcia C, Fischer A, Weill J-C, Reynaud C-A (1998) Defect in IgV gene somatic hypermutation in common variable immuno-deficiency syndrome. Prot Natl Acad Sci USA 95:13135-13140
10. Klein U, Goossens T, Fischer M, Kanzler H, Braeuninger A, Rajewsky K, Küppers R (1998) Somatic hypermutation in normal and transformed human B-cells. Immunol Rev 162:261-280