Membrane-tethered Drosophila Armadillo cannot transduce wingless signal on its own

Development

Volumn 126, Issue 6, 1999, Pages 1327-1335

  Cox, Rachel T ^a   Pai, Li Mei ^a   Miller, Jeffrey R ^b   Orsulic, Sandra ^a   Stein, Joel ^a   McCormick, Carol Ann ^a   Audeh, Yara ^a   Wang, Wei ^a   Moon, Randall T ^b   Peifer, Mark ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

catenin; Armadillo; Drosophila; Wingless; Wnt

Indexed keywords

BETA CATENIN; DNA BINDING PROTEIN; MEMBRANE PROTEIN; MUTANT PROTEIN;

ANIMAL TISSUE; ARTICLE; CELL JUNCTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DROSOPHILA; EMBRYO; FEMALE; MALE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ANIMALS; ARMADILLO DOMAIN PROTEINS; BIOLOGICAL TRANSPORT; CELL COMPARTMENTATION; CELL NUCLEUS; DROSOPHILA; DROSOPHILA PROTEINS; INSECT PROTEINS; MEMBRANE PROTEINS; MUTAGENESIS; NUCLEAR LOCALIZATION SIGNALS; PHOSPHORYLATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

ANIMALIA; ARMADILLO; DROSOPHILA ARMADILLO; HEXAPODA; VERTEBRATA;

EID: 0032908573     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Ahmed, Y., Hayashi, S., Levine, A. and Wieschaus, E. (1998). Regulation of Armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development. Cell 93, 1171-1182.
2. Brand, A. H. and Perrimon, N. (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415.
3. Brannon, M., Gomperts, M., Sumoy, L., Moon, R. T. and Kimelman, D. (1997). A beta-calenin/XTef-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus. Genes Dev: 11, 2359-70.
4. Cavallo, R. A., Cox, R. T., Moline, M. M., Roost, J., Polevoy, G. A., Clevers, H., Peifer, M. and Bejsovec, A. (1998). Drosophila TCF and Groucho interact to repress Wingless signaling activity. Nature 395, 604-608.
5. Cox, R. T., Kirkpatrick, C. and Peifer, M. (1996). Armadillo is required for adherens junction assembly, cell polarity, and morphogenesis during Drosophila embryogenesis. J. Cell Biol. 134, 133-148.
6. Cox, R. T. and Peifer, M. (1998). Wingless/Wnt signaling: The inconvenient complexities of life. Curr. Biol. 8, R140-R144.
7. Cui, Y., Brown, J. D., Moon, R. T. and Christian, J. L. (1995). Xwnt-8b: a maternally expressed Xenopus Wnt gene with a potential role in establishing the dorsoventral axis. Development 121, 2177-2186.
8. Detrick, R. J., Dickey, D. and Kintner, C. R. (1990). The effects of N-cadherin misexpression on morphogenesis in Xenopus embryos. Neuron 4. 493-506.
9. Fagotto, F., Glück, U. and Gumbiner, B. M. (1998). NLS- and importin/kuryopherin-independent nuclear import of β-catenin. Curr. Biol. 8, 181-190.
10. Funayama, N., Fagatto, F., McCrea, P. and Gumbiner, B. M. (1995). Embryonic axis induction by the Armadillo repeat domain of β-catenin: evidence for intracellular signaling. J. Cell Biol. 128, 959-968.
11. Gumbiner, B. M. (1998). Propagation and localization of Wnt signaling. Curr. Opin. Genet. Dev. 8, 430-435.
12. Huber, O., Korn, R., McLaughlin, J., Ohsugi, M., Herrmann, B. G. and Kemler, R. (1996). Nuclear localization of β-catenin by interaction with transcription factor LEF-I. Mech. Dev. 59, 3-10.
13. Jiang, J. and Struhl, G. (1998). Regulation of the Hedgehog and Wingless signaling pathways by the F-Box/WD-40-repeat protein Slimb. Nature 391, 493-496.
14. Kalderon, D., Roberts, B. L., Richardson, W. D. and Smith, A. E. (1984). A short amino acid sequence able to specify nuclear location. Cell 39, 499-509.
15. Karnovsky, A. and Klymkowsky, M. W. (1995). Anterior axis duplication in Xenopus induced by the over-expression of the cadherin-binding protein plakoglobin. Proc. Nat. Acad. Sci. USA 92, 4522-4526.
16. Merriam, J. M., Rubenstein, A. B. and Klymkowsky, M. W. (1997). Cytoplasmically anchored plakoglohin induces a Wnt-like phenotype in Xenopus. Dev. Biol. 185, 67-81.
17. Miller, J. R. and Moon, R. T. (1997). Analysis of the signaling activities of localization mutants of β-catenin during axis speculation in Xenopus. J. Cell Biol. 139, 229-243.
18. Oda, H., Uemura, T., Harada, Y., Iwai, Y. and Takeichi, M. (1994). A Drosophila homolog of cadherin associated with Armadillo and essential for embryonic cell-cell adhesion. Dev. Biol. 165, 716-726.
19. Oda, H., Uemura, T., Shiomi, K., Nagafuchi, A., Tsukita, S. and Takeichi, M. (1993). Identification of a Drosophila homologue of alpha-catenin and its association with armadillo protein. J. Cell Biol. 121, 1133-1140.
20. Orsulic, S. and Peifer, M. (1996). An in vivo structure-function analysis of armadillo, the β-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and wingless signaling. J. Cell Biol. 134, 1283-1301.
21. Pai, L.-M., Orsulic, S., Bejsovec, A. and Peifer, M. (1997). Negative regulation of Armadillo, a Wingless effector in Drosophila. Development 124, 2255-2266.
22. Peifer, M. (1993). The product of the Drosophila segment polarity gene armadillo is part of a multi-protein complex resembling the vertebrate adherens junction. J. Cell Sci. 105, 993-1000.
23. Peifer, M., Orsulic, S., Sweeton, D. and Wieschaus, E. (1993). A role for the Drosophila segment polarity gene armadillo in cell adhesion and cytoskeletal integrity during oogenesis. Development 118, 1191-1207.
24. Peifer, M., Sweeton, D., Casey, M. and Wieschaus, E. (1994a). wingless signal and Zeste-while 3 kinase trigger opposing changes in the intracellular distribution of Armadillo. Development 120, 369-380.
25. Peifer, M., Pai, L.-M. and Casey, M. (1994b). Phosphorylation of the Drosophila adherens junction protein Armadillo: roles for Wingless signal and Zeste white-3 kinase. Dev. Biol. 166, 543-556.
26. Quilliam, L. A., Huff, S. Y., Rabun, K. M., Wei, W., Park, W., Broek, D. and Der, C. J. (1994). Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOSI activation of Ras transforming activity. Proc. Nat. Acad Sci. USA 91, 8512-8516.
27. Riese, J., Yu, X., Munnerlyn, A., Eresh, S., Hsu, S.-C., Grosschedl, R. and Bienz, M. (1997). LKH-1, a nuclear factor coordinating signalling inputs from wingless and decapentaplegic. Cell 88, 777-787.
28. Roose, J., Molenaar, M., Peterson, J., Hurenkamp, J., Brantjes, H., Moerer, P., van de Wetering, M., Destree, O. and Clevers, H. (1998). The Xenopus Wnt effector XTef-3 interacts with Groucho-related transcriptional repressors. Nature 395, 608-612.
29. Suter, B. and Steward, R. (1991). The role of the Bicaudal-D protein and ils phosphorylation in Drosophila oocyte differentiation. Cell 67, 917-926.
30. Tepass, U., Gruszynski-DeFeo, E., Haag, T. A., Omatyar, L., Török, T. and Hartenstein, V. (1996). shotgun encodes Drosophila E-cadherin and is preferentially required during cell rearrangement in the neurectoderm and other morphogenetically active epithelia. Genes Dev. 10, 672-685.
31. Uemura, T., Oda, H., Kraut, R., Hatashi, S., Kataoka, Y. and Takeichi, M. (1996). Zygotic D E-cadherin expression is required for the processes of dynamic epithelial cell rearrangement in the Drosophila embryo. Genes Dev. 10, 659-671.
32. Wen, W., Meinkoth, J. L., Tsien, R. and Taylor, S. S. (1995). Identification of a signal sequence for rapid export of proteins from the nucleus. Cell 82, 463-473.
33. While, P., Aberle, H. and Vincent, J.-P. (1998). Signaling and adhesion activities of mammalian β-catenin and plakoglobin in Drosophila. J. Cell Biol. 140, 183-195.