Cyclin D1 overexpression in Spitz nevi: An immunohistochemical study

American Journal of Dermatopathology

Volumn 21, Issue 2, 1999, Pages 115-120

  Nagasaka, Tetsuro ^a   Lai, Raymond ^b   Medeiros, L Jeffrey ^b   Brynes, Russell K ^e   McCourty, Althea ^b   Harada, Tomoko ^a   Saddik, Maruf ^c,d  

^a NAGOYA UNIVERSITY HOSPITAL   (Japan)

^b CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^c ROYAL UNIVERSITY HOSPITAL   (Canada)

^d UNIVERSITY OF SASKATCHEWAN   (Canada)

^e NONE

Author keywords

Cyclin D1; Ki 67; Malignant melanoma; Spitz nevus

Indexed keywords

CYCLIN D1; KI 67 ANTIGEN; MONOCLONAL ANTIBODY KI 67;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; JUVENILE MELANOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CARRIER PROTEINS; CELL CYCLE PROTEINS; CYCLIN D1; DIAGNOSIS, DIFFERENTIAL; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MELANOMA; NEVUS; NEVUS, EPITHELIOID AND SPINDLE CELL; SKIN; SKIN NEOPLASMS; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTORS;

EID: 0032908548     PISSN: 01931091     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000372-199904000-00001     Document Type: Article

References (20)

1. Elder DE, Murphy GF. Benign melanocytic tumors (nevi). In: Atlas of tumor pathology: melanocytic tumors of the skin. Washington, DC: Armed Forces Institute of Pathology, 1991:5-101.
2. Weinberg RA. The retinoblastoma protein and cell cycle control. Cell 1995:81:323-30.
3. Slansky JE, Farnham PJ, Introduction to the E2F family: protein structure and gene regulation. In: Farnham, PJ, eds. Transcriptional control of cell growth: the E2F gene family. Berlin: Springer, 1996:1-30. Current Topics in Microbiology and Immunology.
4. Hall M, Peter G. Genetic alterations of cyclins, cyclin-dependent kinases and cdk inhibitors in human cancer. Adv Cancer Res 1996; 68:67-108.
5. Hunter T, Pines J. Cyclins and cancer II: cyclin D and cdk inhibitors come of age. Cell 1994;79:573-82.
6. Buckley MF, Sweeney KJE, Hamilton JA, Sini RL, Manning DL, Nicholson RI. Expression and amplification of cyclin genes in human breast cancer. Oncagene 1993;8:2127-33.
7. Lammic GA, Fantl V, Smith R, Schuuring E, Brookes S, Michalides R. D11S287, a putative oncogene on chromosome 11q13 is amplified and expressed in squamous cell and mammary carcinomas and linked to bcl-1. Oncogene 1991;6:439-44.
8. Nakagawa H, Zukerberg L, Tagawa K, Meltzer SJ, Nishihara T, Rustgi AK. Human cyclin D1 oncogene and esophageal squamous cell carcinoma. Cancer 1995;76:541-9.
9. Inohara S, Kitagawa K, Kitano Y. Expression of cyclin D1 and p53 protein in various malignant skin tumors. Dermatology 1996;192: 94-8.
10. Kanter-Lewensohn L, Hedblad MA, Wejde J, Larsson O. Immunohistochemical markers for distinguishing Spitz nevi from malignant melanomas. Mod Pathol 1997;10:917-20.
11. Tu P, Miyauchi S, Miki Y. Proliferative activities in Spitz nevus compared with melanocytic nevus and malignant melanoma using expression of PCNA/cyclin and mitotic rate. Am J Dermatopathol 1993;15:311-4.
12. Helin K, Wu C, Fattaey AR, et al. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative transactivation. Genes Dev 1993;7:1850-61.
13. Brynes RK, McCourty A, Tamayo R, Jenkins K, Battifora H. Demonstration of cyclin D1 (bcl-1) in mantle cell lymphoma: enhanced staining using heat and ultrasound epitope retrieval. Appl Immunohistochem 1997;5:45-8.
14. Brynes RK, McCourty A, Ho JP, Traweek ST, Synder DS, Slovak ML. Detection of the Philadelphia chromosome in paraffin-embedded tissue by fluorescence in-situ hybridization. Mod Pathol 1994;7:565-9.
15. Talve L, Sauroja I, Collan Y, Punnonen K, Ekfors T. Loss of expression of the p16INK4/CDKN2 gene in cutaneous malignant melanoma correlates with tumor cell proliferation and invasive stage. Int J Cancer 1997;74:255-9.
16. Bartkova J, Lukas J, Guldberg P, et al. The p16-cyclin d1/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis. Cancer Res 1996;56:5475-83.
17. El-Deiry WS, Harper JW, O'Connor PM, et al. Waf1/Cip1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res 1994; 54:1169-74.
18. Vidai MJ, Loganzo F Jr, de Oliveira AR, Hayward NK, Albino AP. Mutations and defective expression of the WAF1 p21 tumor-suppressor gene in malignant melanomas. Melanoma Res 1995;5: 243-50.
19. Trotter MJ, Tang L, Tron VA. Overexpression of the cyclin-dependent kinase inhibitor p21 (waf1/cip1) in human cutaneous malignant melanoma. J Cut Pathol 1997;24:265-71.
20. Rieber MS, Rieber M. Suppression of cyclin D1 but not CDK4 or cyclin A with induction of melanoma terminal differentiation. Biochem Biophys Res Commun 1995;216:422-7.