Kinetic analysis of 2-[11C]thymidine PET imaging studies: Validation studies

Journal of Nuclear Medicine

Volumn 40, Issue 4, 1999, Pages 614-624

  Mankoff, David A ^a   Shields, Anthony F ^b   Link, Jeanne M ^b   Graham, Michael M ^b   Muzi, Mark ^b   Peterson, Lanell M ^b   Eary, Janet F ^b   Krohn, Kenneth A ^b  

^a UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

^b NONE

Author keywords

Cancer; Kinetic modeling; PET; Thymidine

Indexed keywords

CARBON 11; THYMIDINE DERIVATIVE;

ANIMAL MODEL; ARTICLE; CELL CYCLE; CELL PROLIFERATION; DIAGNOSTIC IMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT; TREATMENT OUTCOME; TUMOR;

ANIMALS; CARBON DIOXIDE; CARBON RADIOISOTOPES; CELL DIVISION; DNA; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; MODELS, BIOLOGICAL; NEOPLASMS, EXPERIMENTAL; RADIOPHARMACEUTICALS; RATS; RATS, INBRED F344; THYMIDINE; THYMINE; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0032907772     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Christman D. Crawford EJ, Friedkin M, Wolf AP. Detection of DNA synthesis in intact organisms with positron-emitting [methyl [C-11]] thymidine. Proc Natl Acad Sci USA. 1972; 69:988-992.
2. Shields AF, Larson SM, Grunbaum Z, Graham MM. Short-term uptake in normal and neoplastic tissues: studies for PET. J Nucl Med. 1984;25:759-764.
3. 11C]thymidine for quantification of cellular proliferation with PET. Appl Radiat Isot. 1991;42:103-104.
4. 3H]thymidine. and gallium-67. J Nucl Med. 1991;32:2118-2123.
5. 11C labeled thymidine for tumor visualization using positron emission tomography. Appl Radiat Isot. 1985;35:705-708.
6. Link JM, Grierson J, Krohn K. Alternatives in the synthesis of 2-[C-11]-thymidine. J Label Comp Radiopharm. 1995;37:610-612.
7. Martiat P, Ferrant A, Labar D. In vivo measurement of carbon-11 thymidine uptake in non-Hodgkin's lymphoma using positron emission tomography. J Nucl Med. 1988;29:1633-1637.
8. Shields AF, Mankoff DA, Link JM, et al. Monitoring tumor response to chemotherapy with [C-11]-thymidine and FDG PET. J Nucl Med. 1998;39:1757-1762.
9. Shields AF, Mankoff DA, Graham MM, et al. Analysis of 2-[C-11]-thymidine blood metabolites in PET imaging. J Nucl Med. 1996;37:290-296.
10. Goethals P, Eijkeren MV, Lodewyck W, Dams R. Measurement of [methyl-carbon-11]thymidine and its metabolites in head and neck tumors. J Nucl Med. 1995;36:880-882.
11. Shields AF, Lim K, Grierson J, Link J, Krohn KA. Utilization of labeled thymidine in DNA synthesis: studies for PET. J Nucl Med. 1990;31:337-342.
12. Shields AF, Graham MM, Kozawa SM, et al. Contribution of labeled carbon dioxide to PET imaging of carbon-11-labeled compounds. J Nucl Med. 1992;33: 581-584.
13. Mankoff DA, Shields AF, Graham MM, Linke JM, Krohn KA. A graphical analysis method to estimate blood-to-tissue transfer constants for tracers with labeled metabolites. J Nucl Med. 1996;37:2049-2057.
14. Mankoff DA, Shields AF, Graham MM, et al. Kinetic analysis of 2-[C-11]-thymidine PET imaging studies: compartmental model and mathematical analysis. J Nucl Med. 1998;39:1043-1055.
15. Oliver JM, Paterson AP. Nucleoside transport. I. A mediated process in human erythrocytes. Can J Biochem. 1971;49:262-270.
16. Cleaver JE. Thymidine metabolism and cell kinetics. Frontiers Biol. 1967;6:43-100.
17. Pelc SR, Appleton TC. Distribution of tritiated thymidine in various tissues. Nature. 1965;205:1287-1289.
18. Shields AF, Kozell L. Enzymatic preparation of H-3 labeled beta-ureidoisobutyric acid and beta-aminoisobutyric acid. J Label Comp Radiopharm. 1990;28:1417-1419.
19. Cornford EM, Oldendorf WH. Independent blood-brain barrier transport systems for nucleic acid precursors. Biochim Biophys Acta. 1975;394:211-219.
20. Oldendorf WH, Szabo J. Amino acid assignment to one of three blood-brain barrier amino acid carriers. Am J Physiol. 1976; 230:94-98.
21. DeGrado T, Turkington T, Williams J, Steams C, Hoffman J. Performance characteristics of a whole-body PET scanner. J Nucl Med. 1994;35:1398-1406.
22. Lewellen TK, Kohlmyer S, Miyaoka R, Schubert S, Stearns C. Investigation of the count rate performance of the General Electric ADVANCE positron emission tomograph. IEEE Trans Nucl Sci. 1995;42:1051-1057.
23. Spence AM, Graham MM, Muzi M, et al. Feasibility of imaging penlose cycle glucose metabolism in glioma with PET: studies in rat brain tumor models. J Nucl Med. 1997;38:617-624.
24. Spence AM, Coates PW. Scanning electron microscopy of cloned astrocytic lines derived from ethylnitrosurea-induced rat gliomas. Virchows Arch B Cell Pathol. 1978;28:77-85.
25. Rabinovitch PS. DNA content histogram and cell cycle analysis. Meth Cell Biol. 1994;41:263-296.
26. Moolenaar WH, Tertoolen LGJ, deLaat SW. Phorbol ester and diacylglycerol mimic growth factors in raising cytoplasmic pH. Nature. 1984;12:371-374.
27. 2 and positron emission tomography. J Cereb Blood Flow Metab. 1984;4:8-16.
28. Goethels P, Lameire N, Eijken MV, et al. [Methyl-carbon-11]thymidine for in vivo measurement of cell proliferation. J Nucl Med. 1996;37:1048-1052.
29. Molnar P, Groothius D, Blasberg R. et al. Regional thymidine transport and incorporation in experimental brain and subcutaneous tumors. J Neurochem. 1984;43:421-432.
30. Tew KD, Taylor DM. The relationship of thymidine metabolism to the use of fractional incorporation as a measure of DNA synthesis in tissue proliferation. Eur J Cancer. 1978;14:153-168.
31. Nottebrock H, Then R. Thymidine concentrations in serum and urine of different animal species and man. Blochem Pharm. 1977;26:2175-2179.
32. Schmidt K, Mies G, Sokoloff L. Model of kinetic behavior of deoxyglucose in heterogenous tissues in brain: a reinterpretation of the significance of parameters fitted to homogenous tissue models. J Cereb Blood Flow Metab. 1991;11:10-24.
33. Bassingthwaighte JB, Wang CY. Chan IS. Blood-tissue exchange via transport and transformation by endothelial cells. Circ Res. 1989;65:997-1020.
34. Wangler RD, Gorman MW, Wang CY, et al. Transcapillary adenosine transport and interstitial adenosine concentration in guinea pig hearts. Am J Physiol. 1989;257:H89-H106.
35. Bassingthwaighte JB, Goresky CA, Lihehan JH, eds. Whole organ approaches to cellular metabolism. Capillary permeation, cellular uptake and product formation. New York, NY: Springer Verlag; 1998.