Generating FSH antagonists and agonists through immunization against FSH receptor N-terminal decapeptides

Journal of Molecular Endocrinology

Volumn 22, Issue 2, 1999, Pages 151-159

  Abdennebi, L ^a   Couture, L ^a   Grebert, D ^a   Pajot, E ^a   Salesse, R ^a   Remy, J J ^a  

^a CEMAGREF   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; FOLLITROPIN; FOLLITROPIN RECEPTOR; IMMUNOGLOBULIN G; LUTEINIZING HORMONE; THYROTROPIN RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FEMALE; FERTILITY; GAMETOGENESIS; HORMONE ACTION; HORMONE INHIBITION; HORMONE RECEPTOR INTERACTION; IMMUNE RESPONSE; IMMUNIZATION; MOUSE; NONHUMAN; OVARY FOLLICLE MATURATION; OVULATION; PRIORITY JOURNAL;

EID: 0032906449     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.0.0220151     Document Type: Article

References (23)

1. Aittomaki K, Lucena J, Pakarinen P, Sistonen P, Tapanainen J, Gromoll J, Kaskikari R, Sankila E, Lehvöslaiho H, Engel A, Nieschlag E, Hutaniemi I & de la Chapelle A 1995 Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure. Cell 82 959-968.
2. Aittomaki K, Herva R, Stenman U-H, Juntunnen K, Ylöstalto P, Hovatta O & de la Chapelle A 1996 Clinical features of primary ovarian failure caused by a point mutation in the follicle-stimulating hormone receptor gene. Journal of Clinical Endocrinology and Metabolism 81 3722-3726.
3. Bhowmick N, Huang JN, Puett D, Isaacs NW & Lapthorn AJ 1996 Determination of residues important in hormone binding to the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor by site-directed mutagenesis and modeling. Molecular Endocrinology 10 1147-1159.
4. Braun T, Schofield P & Sprengel R 1991 Amino-terminal leucine-rich repeats in gonadotropin receptors determine hormone selectivity. EMBO Journal 10 1885-1890.
5. Cockett M, Yarranton G & Bebbington C 1990 High level expression of tissue inhibitor of metalloproteinases in Chinese hamster ovary cells using glutamine synthetase gene amplification. Bio/Technology 8 662-667.
6. Couture L, Naharisoa H, Grebert D, Remy J-J, Pajot-Augy E, Haertle T & Salesse R 1996 Peptide and immunochemical mapping of the ectodomain of the porcine LH receptor. Journal of Molecular Endocrinology 16 15-25.
7. Dattatreyamurty B & Reichert LE 1992 A synthetic peptide corresponding to amino acids 9-30 of the extracellular domain of the follitropin (FSH) receptor specifically binds FSH. Molecular and Cellular Endocrinology 87 9-17.
8. Dierich A, Sairam MR, Monaco L, Fimia GM, Gansmuller A, Lemeur M & Sassone-Corsi P 1998 Impairing follicle-stimulating hormone (FSH) signaling in vivo: targetted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance. Proceedings of the National Academy of Sciences of the USA 95 13612-13617.
9. Greenwood J, Willis A & Perham R 1991 Multiple display of foreign peptides on filamentous bacteriophage. Journal of Molecular Biology 220 821-827.
10. Hong S, Phang T, Ji I & Ji TH 1998 The amino-terminal region of the luteinizing hormone/choriogonadotropin receptor contacts both subunits of human choriogonadotropin. Journal of Biological Chemistry 273 13835-13840.
11. Jiang X, Dreano M, Buckler D, Cheng S, Ythier A, Wu H, Hendrickson W & El Tayar N 1995 Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions. Structure 3 1341-1353.
12. Kajava A, Vassart G & Wodak S 1995 Modeling of the three-dimensional structure of proteins with the typical leucine-rich repeats. Structure 3 867-877.
13. Kumar TR, Wang Y, Lu N & Matzuk MM 1997 Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility. Nature Genetics 15 201-204.
14. Lapthorn A, Harris D, Littlejohn A, Lustbader J, Canfield R, Machin K, Morgan F & Isaacs N 1994 Crystal structure of human chorionic gonadotropin. Nature 369 455-461.
15. Mathews CH, Borgato S, Beck-Peccoz P, Adams M, Tone Y, Gambino G, Casagrande S, Tedeschini G, Benedetti A & Chaterjee VK 1993 Primary amenorrhoea and infertility due to a mutation in the β-subunit of follicle-stimulating hormone. Nature Genetics 5 83-86.
16. Morris J, Berger E & McCormick D 1993 Structure-function studies of the thyrotropin receptor. Inhibition of binding of labeled thyrotropin (TSH) by synthetic human TSH receptor peptides. Journal of Biological Chemistry 268 10900-10905.
17. Phang T, Kundu G, Hong S, Ji I & Ji TH 1998 The amino-terminal region of the luteinizing hormone/ choriogonadotropin receptor contacts both subunits of human choriogonadotropin. Journal of Biological Chemistry 273 13841-13847.
18. Remy JJ, Labib-Mansais Y, Yerle M, Bozon V, Couture L, Pajot E, Grebert D & Salesse R 1995 The procine follitropin receptor: cDNA cloning, functional expression and chromosomal localisation of the gene. Gene 163 257-261.
19. Remy JJ, Couture L, Rabesona H, Haertle T & Salesse R 1996a Immunization against exon 1 decapeptides from the lutropin/choriogonadotropin receptor or the follitropin receptor as potential male contraceptive. Journal of Reproductive Immunology 32 37-54.
20. Remy JJ, Couture L, Pantel J, Haertle T, Rabesona H, Bozon V, Pajot-Augy E, Robert P, Troalen F, Salesse R & Bidart M 1996b Mapping of hCG-receptor complexes. Molecular and Cellular Endocrinology 125 79-91.
21. Roche P, Ryan R & McCormick D 1992 Identification of the hormone-binding regions of the luteinizing hormone/human chorionic gonadotropin receptor using synthetic peptides. Endocrinology 131 268-274.
22. Salesse R & Garnier J 1996 Glycoprotein hormone receptors: new molecular supports for old biological functions. Biomembranes 2B 143-217.
23. Taipanainen JS, Aittomöki K, Min J, Vaskivuo, T & Hutaniemi IT 1997 Men homozygous for an inactivating mutation in the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility. Nature Genetics 15 205-206.