Synthesis of novel 5-aryl-6-cyano-3H,8H-pyrido[2,3-d]pyrimidine-4,7- diones in the reaction of 6-amino-4-pyrimidinones with benzaldehyde and ethyl cyanoacetate

Journal of Heterocyclic Chemistry

Volumn 36, Issue 1, 1999, Pages 113-115

  Quiroga, Jairo ^a   Alvarado, Mario ^a   Insuasty, Braulio ^a   Nogueras, Manuel ^b   Sánchez, Adolfo ^b   López, M Dolores ^b  

^a UNIVERSIDAD DEL VALLE   (Colombia)

^b UNIVERSITY OF JAÉN   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

6 AMINO 4 PYRIMIDINE; ANTIBIOTIC AGENT; ANTICOAGULANT AGENT; ANTINEOPLASTIC AGENT; DIURETIC AGENT; PYRIDO[2,3 D]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; DIURESIS; DRUG CONFORMATION; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION INHIBITION;

EID: 0032906107     PISSN: 0022152X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jhet.5570360117     Document Type: Article

References (23)

1. W. J. Irwin and D. G. Wibberley, Adv. Heterocyclic Chem., 10, 149 (1969).
2. B. S. Herbert, R. Ferone, T. A. Herman, G. H. Hitchings, M. Barnelt and S. R. Bushby, J. Med. Chem., 11, 711 (1968).
3. G. L. Anderson and A. D. Broom, J. Org. Chem., 42, 997 (1977).
4. L. Prakash, M. Shaihla and R. L. Mital, Pharmazie, 44, 490 (1989).
5. E. Lunt and C. C. Newton, Comprehensive Heterocyclic Chemistry, A. R. Katritzky and C. W. Rees, Vol 3, A. J. Boulton and A. Mc Killop, eds, Pergamon Press, Oxford, 1984, pp 199-232 and pp 260-261.
6. L. K. A. Rahman and S. R. Chhabra, Med. Res. Rev., 8, 95 (1988).
7. J. Matsumoto and S. Minami, J. Med. Chem., 18, 74 (1975).
8. N. Suzuki, Chem. Pharm. Bull., 28, 761 (1980).
9. G. L. Anderson, J. L. Shim and A. D. Broom, J. Org. Chem., 41, 1095 (1976).
10. E. M. Grivsky, S. Lee, C. W. Sigel, D. S. Duch and C. A. Nichol, J. Med. Chem., 23, 327 (1987).
11. A. Gangjee, A. Vasudevan, F. Queener and R. Kisliuk, J. Med. Chem., 38, 1778 (1995); A. Gangiee, U.S. Patent 5,508,281 (1996); Chem. Abstr., 125, 33667a, (1996); A. Gangjee, A. Vasudevan, F. Queener and R. Kisliuk, J. Med. Chem., 39, 1438 (1996).
12. A. Gangjee, A. Vasudevan, F. Queener and R. Kisliuk, J. Med. Chem., 38, 1778 (1995); A. Gangiee, U.S. Patent 5,508,281 (1996); Chem. Abstr., 125, 33667a, (1996); A. Gangjee, A. Vasudevan, F. Queener and R. Kisliuk, J. Med. Chem., 39, 1438 (1996).
13. A. Gangjee, A. Vasudevan, F. Queener and R. Kisliuk, J. Med. Chem., 38, 1778 (1995); A. Gangiee, U.S. Patent 5,508,281 (1996); Chem. Abstr., 125, 33667a, (1996); A. Gangjee, A. Vasudevan, F. Queener and R. Kisliuk, J. Med. Chem., 39, 1438 (1996).
14. A. Gangjee, A. Vasudevan, F. Queener and R. Kisliuk, J. Med. Chem., 38, 1778 (1995); A. Gangiee, U.S. Patent 5,508,281 (1996); Chem. Abstr., 125, 33667a, (1996); A. Gangjee, A. Vasudevan, F. Queener and R. Kisliuk, J. Med. Chem., 39, 1438 (1996).
15. S. A. K. Sharma and L. Prakash, Heterocyclic Commun., 1, 89 (1994).
16. A. Monge, V. Martinez, C. San Martín and M. A. Simon, Spanish Patent ES 2,056,742 (1994); Chem. Abstr., 122, 105912q (1995).
17. G. Hou, D. Gravier, F. Casadebaig, J. Dupin, H. Bernard and M. Boiseau, Pharmazie, 50, 719 (1995).
18. J. Quiroga, B. Insuasty, A. Sánchez, M. Nogueras and H. Meier, J. Heterocyclic Chem., 29, 1045 (1992).
19. J. Quiroga, J. García, B. Insuasty, N. L. Mendoza, M. Pungo and H. Meier, An. Quim., 90, 3-4C, 300 (1994).
20. J. Quiroga, A. Hormaza, B. Insuasty, A. Sánchez, M. Nogueras, N. Hanold and H. Meier, J. Heterocyclic Chem., 34, 521 (1997).
21. B. Insuasty, J. Quiroga, H. Meier, Trends Heterocyclic Chem., 5, 83 (1997).
22. J. Quiroga, A. Hormaza, B. Insuasty, A. J. Ortíz, A. Sánchez and M. Nogueras, J. Heterocyclic Chem., 35, 231 (1998).
23. J. Quiroga, M. Alvarado, B. Insuasty, A. Sánchez, M. Nogueras and J. Cobo, J. Heterocyclic Chem., (1998), in press.