Cytokine endpoints for the local lymph node assay: Consideration of interferon-γ and interleukin 12

Journal of Applied Toxicology

Volumn 19, Issue 3, 1999, Pages 149-135

  Dearman, R J ^a   Hilton, J ^a   Basketter, D A ^b   Kimber, I ^a  

^a ASTRAZENECA   (United Kingdom)

^b UNILEVER RESEARCH   (United Kingdom)

Author keywords

Interferon ; Interleukin 12; Local lymph node assay; Skin sensitization

Indexed keywords

4 AMINOBENZOIC ACID; ACETONE; CHEMICAL AGENT; CINNAMALDEHYDE; CONTACT ALLERGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; OLIVE OIL; OXAZOLONE; PROTEIN P40; THYMIDINE; TRITIUM;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOASSAY; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; LYMPH NODE; LYMPH NODE CELL; LYMPHATIC DRAINAGE; MATHEMATICAL PARAMETERS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN SENSITIZATION;

ANIMALIA; MURINAE; TRITIUM; TRIXIS;

EID: 0032905141     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1263(199905/06)19:3<149::AID-JAT557>3.0.CO;2-L     Document Type: Article

References (34)

1. I. Kimber and D. A. Basketter, The murine local lymph node assay. A commentary on collaborative studies and new directions. Food Chem. Toxicol. 30, 165-169 (1992).
2. I. Kimber, R. J. Dearman, E. W. Scholes and D. A. Basketter, The local lymph node assay: developments and applications. Toxicology 93, 13-31 (1994).
3. I. Kimber, J. Hilton, P. A. Botham, D. A. Basketter, E. W. Scholes, K. Miller, M. C. Robbins, P. T. C. Harrison, T. J. B. Gray and S. J. Waite, The murine local lymph node assay: results of an inter-laboratory trial. Toxicol. Lett. 55, 203-213 (1991).
4. D. A. Basketter, E. W. Scholes, I. Kimber, P. A. Botham, J. Hilton, K. Miller, M. C. Robbins, P. T. C. Harrison and S. J. Waite, Inter-laboratory evaluation of the local lymph node assay with 25 chemicals and comparison with guinea pig test data. Toxicol. Meth. 1, 30-43 (1991).
5. E. W. Scholes, D. A. Basketter, A. E. Sarll, I. Kimber, C. D. Evans, K. Miller, M. C. Robbins, P. T. C. Harrison and S. J. Waite, The local lymph node assay: results of a final inter-laboratory validation under field conditions. J. Appl. Toxicol. 12, 217-222 (1992).
6. I. Kimber, J. Hilton, R. J. Dearman, G. F. Gerberick, C. A. Ryan, D. A. Basketter, E. W. Scholes, G. S. Ladics, S. E. Loveless, R. V. House and A. Guy, An international evaluation of the murine local lymph node assay and comparison of modified procedures. Toxicology 103, 63-73 (1995).
7. S. E. Loveless, G. S. Ladics, G. F. Gerberick, C. A. Ryan, D. A. Basketter, E. W. Scholes, R. V. House, J. Hilton, R. J. Dearman and I. Kimber, Further evaluation of the local lymph node assay in the final phase of an international collaborative trial. Toxicology 108, 141-152 (1996).
8. I. Kimber, J. Hilton, R. J. Dearman, G. F. Gerberick, C. A. Ryan, D. A. Basketter, L. Lea, R. V. House, G. S. Ladics, S. E. Loveless and K. L. Hastings, Assessment of the skin sensitization potential of topical medicaments using the local lymph node assay: an interlaboratory evaluation. J. Toxicol. Environ. Health 53, 563-579 (1998).
9. I. Kimber, J. Hilton and P. A. Botham, Identification of contact allergens using the murine local lymph node assay: comparisons with the Buehler occluded patch test in guinea pigs. J. Appl. Toxicol. 10, 173-180 (1990).
10. D. A. Basketter and E. W. Scholes, Comparison of the local lymph node assay with the guinea-pig maximization test for the detection of a range of contact allergens. Food Chem. Toxicol. 30, 63-67 (1992).
11. D. A. Basketter, E. W. Scholes and I. Kimber, The performance of the local lymph node assay with chemicals identified as contact allergens in the human maximization test. Food Chem. Toxicol. 32, 543-547 (1994).
12. D. A. Basketter, G. F. Gerberick, I. Kimber and S. E. Loveless, The local lymph node assay: a viable alternative to currently accepted skin sensitization tests. Food Chem. Toxicol. 34, 985-997 (1996).
13. I. Kimber and R. J. Dearman, Investigation of lymph node cell proliferation as a possible immunological correlate of contact sensitizing potential. Food Chem. Toxicol. 29, 125-129 (1991).
14. C. Boussiquet-Leroux, G. Durand-Cavagna, K. Herlin and D. Holder, Evaluation of lymphocyte proliferation by immunohistochemistry in the local lymph node assay. J. Appl. Toxicol. 15, 465-475 (1995).
15. P. Ulrich, B. Homey and H-W. Vohr, A modified murine local lymph node assay for the differentiation of contact photoallergy from phototoxicity by analysis of cytokine expression in skin-draining lymph node cells. Toxicology 125, 149-168 (1998).
16. R. J. Dearman, J. C. Hope, S. J. Hopkins, R. J. Debicki and I. Kimber, Interleukin 6 (IL-6) production by lymph node cells: an alternative endpoint for the murine local lymph node assay. Toxicol. Meth. 3, 268-278 (1993).
17. B. Xu, K. Aoyama and A. Ueda, In vitro evaluation of contact sensitivity to DNCB using hapten-stimulated in vitro interleukin-2 production by murine lymph node cells. Toxicol. Meth. 3, 183-194 (1993).
18. R. J. Dearman, E. W. Scholes, L. S. P. Ramdin, D. A. Basketter and I. Kimber, The local lymph node assay: an interlaboratory evaluation of interleukin 6 (IL-6) production by draining lymph node cells. J. Appl. Toxicol. 14, 287-291 (1994).
19. M. Hatao, T. Hariya, Y. Katsumura and S. Kato, A modification of the local lymph node assay for contact allergenicity screening: measurement of interleukin-2 as an alternative to radioisotope-dependent proliferation assay. Toxicology 98, 15-22 (1995).
20. M. B. Lappin, R. J. Dearman, M. Norval and I. Kimber, Lack of association between interleukin-6 production by contact allergen-activated lymph node cells and lympho-proliferative activity. Am. J. Contact Derm. 9, 34-39 (1998).
21. T. A. T. Fong and T. R. Mosmann, The role of IFN-γ in delayed type hypersensitivity mediated by Th1 clones. J. Immunol. 143, 2887-2893 (1989).
22. H. C. Maguire Jr., Murine recombinant interleukin-12 increases the acquisition of allergic contact dermatitis in mice. Int. Arch. Allergy Immunol. 106, 166-168 (1995).
23. H. Riemann, A. Schwarz, S. Grabbe, Y. Aragne, T. A. Luger, M. Wysocka, M. Kubin, G. Trinchieri and T. Schwartz, Neutralization of IL-12 in vivo prevents induction of contact hypersensitivity and induces hapten-specific tolerance. J. Immunol. 156, 1799-1803 (1996).
24. G. Trinchieri and P. Scott, The role of interleukin 12 in the immune response, disease and therapy. Immunol. Today 15, 460-463 (1994).
25. J. Magram, S. E. Connaughton, R. R. Warrier, D. M. Carvajal, C-Y. Wu, J. Ferrante, C. Stewart, U. Sarimiento, D. A. Faherty and M. K. Gately, IL-12 deficient mice are defective in IFN-γ production and type 1 cytokine responses. Immunity 4, 471-481 (1996).
26. I. Kimber and D. A. Basketter, Contact sensitization: a new approach to risk assessment. Hum. Ecol. Risk Assess. 3, 385-395 (1997).
27. R. J. Dearman, D. A. Basketter and I. Kimber, Selective induction of type 2 cytokines following topical exposure of mice to platinum salts. Food Chem. Toxicol. 36, 199-207 (1998).
28. R. J. Dearman, D. A. Basketter and I. Kimber, Differential cytokine production following chronic exposure of mice to chemical respiratory and contact allergens. Immunology 86, 545-550 (1995).
29. R. J. Dearman, D. A. Basketter and I. Kimber, Characterization of chemical allergens as a function of divergent cytokine secretion profiles induced in mice. Toxicol. Appl. Pharmacol. 138, 308-316 (1996).
30. R. J. Dearman, S. Smith, D. A. Basketter and I. Kimber, Classification of chemical allergens according to cytokine secretion profiles of murine lymph node cells. J. Appl. Toxicol. 17, 53-62 (1997).
31. R. J. Dearman, D. A. Basketter, P. Evans and I. Kimber, Comparison of cytokine secretion profiles provoked in mice by glutaraldehyde and formaldehyde. Clin. Exp. Allergy 29, 124-128 (1999).
32. + T cells. Immunol. Rev. 123, 206-229 (1991).
33. M. Bette, S. C. Jin, T. Germann, M. K. Schafer, E. Weihe, E. Rude and B. Fleischer, Differential expression of mRNA encoding interleukin-12 p35 and p40 subunits in situ. Eur. J. Immunol. 10, 2435-2440 (1994).
34. G. Trinchieri, Interleukin 12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 84, 4008-4027 (1994).