Ascending neural pathways in the isolated guinea-pig ileum: Effect of muscarinic M1, M2 and M3 cholinergic antagonists

Neuroscience

Volumn 91, Issue 4, 1999, Pages 1575-1580

  Izzo, A A ^a   Mascolo, N ^a   Di Carlo, G ^b   Capasso, F ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

Author keywords

Enteric nervous system; Intestinal motility; Myenteric plexus; Neuronal circuit; Small intestine

Indexed keywords

METHOCTRAMINE; MUSCARINIC M1 RECEPTOR ANTAGONIST; MUSCARINIC M2 RECEPTOR ANTAGONIST; MUSCARINIC M3 RECEPTOR ANTAGONIST; PIRENZEPINE;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ELECTRIC FIELD; ELECTROSTIMULATION; GUINEA PIG; INTESTINE MOTILITY; MALE; MYENTERIC PLEXUS; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; SMALL INTESTINE; SYNAPSE;

ACETYLCHOLINE; AFFERENT PATHWAYS; ANAL CANAL; ANIMALS; DIAMINES; ELECTRIC STIMULATION; GUINEA PIGS; ILEUM; MALE; MOUTH; MUSCARINIC ANTAGONISTS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PIPERIDINES; PIRENZEPINE;

EID: 0032904448     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(98)00641-1     Document Type: Article

References (22)

1. Burks T. F. (1994) Neurotransmission and neurotransmitters. In Physiology of the Gastrointestinal Tract (ed. Johnson R. L.), pp. 211-242. Raven, New York.
2. Damman F., Fuder H., Giachetti A., Giraldo E., Kilbinger H., Micheletti R. AF-DX 116 differentiates between prejunctional muscarinic receptors located on noradrenergic and cholinergic nerves. Naunyn-Schmiedeberg's Arch. Pharmac. 339:1989;268-271.
3. 3 muscarinic receptors in the circular muscle of the guinea-pig ileum. Naunyn-Schmiedeberg's Arch. Pharmac. 351:1995;237-243.
4. Doods H.N., Entzeroth M., Ziegler H., Mayer N., Holzer P. Pharmacological profile of selective muscarinic receptor antagonists on guinea-pig ileal smooth muscle. Eur. J. Pharmac. 253:1994;241-275.
5. 3 receptors in guinea-pig ileum and atria in vitro. Br. J. Pharmac. 109:1993;946-952.
6. Eglen R.M., Hegde S.S., Watson N. Muscarinic receptor subtypes and smooth muscle function. Pharmac. Rev. 48:1996;531-565.
7. Eglen R.M., Reddy H., Watson N., Challis R.A.J. Muscarinic receptor subtypes in smooth muscle. Trends pharmac. Sci. 15:1994;114-117.
8. 2 muscarinic receptors in the guinea pig ileum. Life Sci. 56:1995;956-971.
9. Elze M., Figala V. Affinity and selectivity of biperiden enantiomers for muscarinic receptor subtypes. Eur. J. Pharmac. 158:1988;11-19.
10. Ford A.P.D.W, Levine W.B., Baxter G.S., Harris G.C., Eglen R.M., Whiting R.L. Pharmacological, biochemical and molecular characterization of muscarinic receptors in the guineapig ileum: a multidisciplinary study. Molec. Neuropharmac. 1:1991;117-127.
11. Galligan J.J., North R.A., Tokimasa T. Muscarinic agonists and potassium currents in guinea-pig myenteric neurones. Br. J. Pharmac. 96:1989;193-203.
12. Giraldo E., Monferini E., Ladinsky H., Hammer R. Muscarinic receptor heterogeneity in guinea-pig intestinal smooth muscles: binding studies with AF-DX 116. Eur. J. Pharmac. 141:1987;475-477.
13. Hammer R., Berrie C.P., Birdsall N.J.M., Burgen A.S.V., Helme E.C. Pirenzepine distinguishes between different subclasses of muscarinic receptors. Nature. 283:1980;90-92.
14. 1 receptor activation. Eur. J. Pharmac. 331:1997;213-219.
15. Izzo A.A., Mascolo N., Costa M., Capasso F. Effect of papaverine on synaptic transmission in the guinea-pig ileum. Br. J. Pharmac. 121:1997;768-772.
16. Kilbinger H., Nafziger M. Two types of neuronal muscarinic receptors modulating acetylcholine release from guinea-pig myenteric plexus. Naunyn-Schmiedeberg's Arch. Pharmac. 328:1985;304-310.
17. Lambrecht G., Feifel R., Wagner-Roder M., Strohmann L., Zilch H., Tacke R., Waelbroek M., Christophe J., Boddeke H., Mutschler E. Affinity profiles of hexahydro-sila-difenidol analogues at muscarinic receptor subtypes. Eur. J. Pharmac. 168:1989;71-80.
18. Melchiorre C. Polymethylene tetramines: a new generation of selective muscarinic antagonists. Trends pharmac. Sci. 9:1988;216-220.
19. Richards M.H. Phannacology and second messenger interactions of cloned muscarinic receptors. Biochem. Pharmac. 42:1991;1645-1653.
20. 3 receptors on acetylcholine release from guinea pig ileum as measured directly. Eur. J. Pharmac. 249:1993;1-6.
21. Tonini M., Costa M. A pharmacological analysis of the neuronal circuitry involved in distension-evoked enteric excitatory reflex. Neuroscience. 38:1990;787-795.
22. 3 receptors in guinea-pig trachea: effects of receptor alkylation. Eur. J. Pharmac. 278:1995;195-201.