Effect of papaverine on synaptic transmission in the guinea-pig ileum

British Journal of Pharmacology

Volumn 121, Issue 4, 1997, Pages 768-772

  Izzo, Angelo A ^a   Mascolo, Nicola ^a   Costa, Marcello ^b   Capasso, Francesco ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b FLINDERS UNIVERSITY   (Australia)

Author keywords

Calcium channels; Electrical stimulation; Enteric nervous system; Intestinal motility; Nicotinic transmission; Noradrenaline; Phosphodiesterases

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; CALCIUM CHANNEL; CALCIUM ION; HEXAMETHONIUM; ISOBUTYLMETHYLXANTHINE; NIFEDIPINE; NORADRENALIN; OMEGA CONOTOXIN GVIA; PAPAVERINE; PHENTOLAMINE; PHOSPHODIESTERASE INHIBITOR; SPASMOLYTIC AGENT; TETRODOTOXIN; THEOPHYLLINE; VERAPAMIL;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTROSTIMULATION; GUINEA PIG; ILEUM; INTESTINE INNERVATION; INTESTINE MOTILITY; MALE; NERVE TRACT; NEUROTRANSMISSION; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTION; SYMPATHETIC NERVE; SYNAPSE; SYNAPTIC TRANSMISSION;

1-METHYL-3-ISOBUTYLXANTHINE; ANIMALS; CALCIUM CHANNELS; ELECTRIC STIMULATION; GASTROINTESTINAL MOTILITY; GUINEA PIGS; ILEUM; MALE; PAPAVERINE; PHOSPHORIC DIESTER HYDROLASES; SYNAPTIC TRANSMISSION; THEOPHYLLINE;

EID: 0030994312     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701142     Document Type: Article

References (32)

1. AIKAWA, T., SEKIZAWA, MORIKAWA, M.K., ITABASHI, S., SASAKI, H. & TAKISHIMA, T. (1992). The role of cyclic AMP in non-adrenergic non-cholinergic contraction in guinea-pig bronchi. Br. J. Pharmacol., 105, 609-612.
2. BARLINSKI, J., LOCKHART, A. & FROSSARD, N. (1992). Modulation by theophylline and enprofylline of the excitatory non-cholinergic transmission in guinea-pig bronchi. Eur. Respir. J., 5, 1201-1205.
3. BEAVO, J.A. (1995). Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol. Rev., 75, 725-747.
4. 3H]noradrenaline release from chick sympathetic neurones: role of cyclic AMP. J. Neurochem., 63, 146-154.
5. BROOKES, S.J.H., STEELE, P. & COSTA, M. (1991). Identification and immunohistochemistry of cholinergic and non-cholinergic circular muscle motor neurons in the guinea-pig small intestine. Neuroscience, 42, 863-878.
6. 3H]-noradrenaline release during nerve stimulation in the perfused cat spleen. Br. J. Pharmacol., 63, 97-109.
7. CUBEDDU, L., BARNES, X.E. & WEINER, N. (1974). Release of norepinephrine and dopamine β-hydroxylase by nerve stimulation. II. Effects of papaverine. J. Pharmacol. Exp. Ther., 191, 444-457.
8. FURNESS, J.B. & COSTA, M. (1987). The Enteric Nervous System. Edinburgh: Churchill Livingstone.
9. HOFFMAN, B.B. & LEFKOWITZ, R.J. (1995). Catecholamines, sympathomimetic drugs, and adrenergic receptor antagonists. In Goodman & Gilman's The Pharmacological Basis of Therapeutics, ed. Hardman, J.G., Limbird, L.E., Molinoff, P.B., Ruddon, R.W. & Goodman Gilman, A. pp. 199-248. New York: McGraw-Hill.
10. IZZO, A.A., PERILLI, S., COSTA, M., MASCOLO, N. & CAPASSO, F. (1996). Papaverine inhibits synaptic transmission in the guinea-pig ileum. Fundam. Clin. Pharmacol., 10, 197 (Abstract).
11. 45Ca ions in subcellular fractions of hog biliary muscles. Biochem. Pharmacol., 33, 281-286.
12. LUDVIG, N.V., BURMEISTER, V., JOBE, P.C. & KINCAID, R.L. (1991). Electron microscopic immunocytochemical evidence that the calmodulin-dependent cyclic nucleotide phosphodiesterase is localized predominantly at postsynaptic sites in the rat brain. Neuroscience, 44, 491-500.
13. MCCLESKEY, E.W, FOX, A.P., FELDMAN, D.H., CRUZ, L.J., OLIVERA, B.M., TSIEN, R.W. & YOSHIKAMI, D. (1987). ω-Conotoxin: direct and persistent blockade of specific types of calcium channels in neurons but not muscle. Proc. Natl. Acad. Sci. U.S.A., 84, 4327-4331.
14. 2 stimulation of acetylcholine release from guinea pig myenteric plexus neurons. Am. J. Surg., 166, 552-556.
15. NEEDLEMAN, P., CORR, P.B. & JOHNSON, E.M. (1985). Drugs used for the treatment of angina: organic nitrates, calcium channel blockers and β-adrenergic antagonists. In Goodman and Gilman's The Pharmacological Basis of Therapeutics, ed. Goodman Gilman, A., Goodman, L.S., Rall, T.W. & Murad, F. pp. 806-826. New York: Macmillan Publishing Company.
16. PALMER, J.M., WOOD, J.D. & ZAFIROV, D.H. (1987). Transduction of aminergic and peptidergic signals in enteric neurones of the guinea-pig. J. Physiol., 387, 371-383.
17. ++ channels. J. Pharmacol. Exp. Ther., 270, 788-794.
18. QIAN, Y., GIRARD, V., MARTIN, C.A., MOLIMARD, M. & ADVENIER, C. (1994). Rolipram, but not siguazodan or zaprinast, inhibits the excitatory noncholinergic neurotransmission in guinea pig-bronchi. Eur. Respir. J., 7, 306-610.
19. SMELLIE, F.W., DAVIS, C.W., DALY, J.W. & WELLS, J.N. (1979). Alkylxanthines: Inhibition of adenosine-elicited accumulation of cyclic AMP in brain slices and of brain phosphodiesterase activity. Life Sci., 24, 2475-2482.
20. SPEDDING, M. & PAOLETTI, E. (1992). III. Classification of calcium channels and the sites of action of drugs modifying channel function. Pharmacol. Rev., 44, 363-376.
21. SPINA, D., HARRISON, S. & PAGE, C.P. (1995). Regulation by phosphodiesterase isoenzymes of non-adrenergic non-cholinergic contraction in guinea-pig isolated main bronchus. Br. J. Pharmacol., 116, 2334-2340.
22. TAKEUCHI, T., HATA, F. & YAGASAKI, O. (1992). Role of cyclic AMP in prostaglandin-induced modulation of acetylcholine release from the myenteric plexus of guinea pig ileum. Japan. J. Pharmacol., 60, 327-333.
23. TAMURA, K. & WOOD, J.D. (1989). Electrical and synaptic properties of myenteric plexus neurones in the terminal large intestine of the guinea-pig. J. Physiol., 415, 275-289.
24. THORNBURY, K.D., DONAGHY, K.M. & PEAKE, J. (1995). Characteristics of the NANC post-stimulus ('rebound') contraction of the urinary bladder neck muscle in sheep. Br. J. Pharmacol., 116, 2441-2456.
25. TONINI, M. & COSTA, M. (1990). A pharmacological analysis of the neuronal circuitry involved in distension-evoked enteric excitatory reflex. Neuroscience, 38, 787-795.
26. UNDEM, B.J., MEEKER, S.N. & CHEN, J. (1994). Inhibition of neurally mediated nonadrenergic, noncholinergic contractions of guinea pig bronchus by isozyma-selective phosphodiesterase inhibitors. J. Pharmacol. Exp. Ther., 271, 811-817.
27. WALKER, K.A., BOOTS, M.R., STUBBINS, J.F., ROGERS, M.E. & DAVIS, C.W. (1983). 1-(4-Aminobenzyl)- and 1-(4-aminopheny-1)isoquinolines derivatives: synthesis and evaluation as potential irreversible cyclic nucleotide phosphodiesterase inhibitors. J. Med. Chem., 28, 537-543.
28. WEISHAAR, R.R., BURROWS, S., KOBYLARZ, D.C., QUADE, M.M. & EVANS, D.B. (1986). Multiple molecular forms of cyclic nucleotide phosphodiesterase in cardiac and smooth muscle and in platelets. Biochem. Pharmacol., 35, 787-793.
29. WOOD, J.D. (1987). Physiology of the enteric nervous system. In Physiology of the Gastrointestinal Tract. ed. Johnson, L.R. pp. 67-110. New York: Raven Press.
30. YAN, C.J.C., BENTLEY, W.K., SONNENBURG, W.K. & BEAVO, J.A. (1993). Differential expression of the 61 kDa and 63 kDa calmodulin-dependent phosphodiesterases in the mouse brain. J. Neurosci., 14, 973-984.
31. YAU, W.M., DORSETT, J.A. & YOUTHER, M.L. (1987). Stimulation of acetylcholine release from myenteric neurons of guinea pig small intestine by forskolin and cyclic AMP. J. Pharmacol. Exp. Ther., 243, 507-510.
32. ZAFIROV, D.H., COOKE, H.J. & WOOD, J.D. (1993). Elevation of cAMP facilitates noradrenergic transmission in submucous neurons. Am. J. Physiol., 264, G442-G446.