Flunitrazepam rapidly reduces GABA(A) receptor subunit protein expression via a protein kinase C-dependent mechanism

British Journal of Pharmacology

Volumn 124, Issue 7, 1998, Pages 1338-1340

  Johnston, Jonathan D ^a   Price, Sally A ^a   Bristow, David R ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Benzodiazepines; Cerebellar granule cells; GABA(A) receptor; Protein down regulation; Protein kinase C

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BISINDOLYLMALEIMIDE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; FLUNITRAZEPAM; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; RECEPTOR SUBUNIT;

ANIMAL CELL; ARTICLE; CEREBELLUM; CONTROLLED STUDY; GRANULE CELL; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION;

ANIMALS; CELLS, CULTURED; CEREBELLUM; CYTOPLASMIC GRANULES; ENZYME INHIBITORS; FLUNITRAZEPAM; GABA MODULATORS; INDOLES; ISOQUINOLINES; MALEIMIDES; PROTEIN KINASE C; RATS; RECEPTORS, GABA-A; SULFONAMIDES;

EID: 0031829637     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702012     Document Type: Article

References (12)

1. BRISTOW, D.R. & MARTIN, I.L. (1987). Solubilisation of the benzodiazepine receptor from rat cerebellum by the detergent n-octylpentaoxyethylene. J. Neurochem., 48, 1537-1540.
2. 1 subunit protein in rat cerebellar granule cells. Br. J. Pharmacol., 118, 1103-1110.
3. A benzodiazepine receptor polypeptides from the surface of chick cortical neurons. J. Biol. Chem., 269, 1548-1553.
4. CHIJIWA, T. MISHIMA, A., HAGIWARI, M., SANO, M., HAYASHI, K., INOUE, T., NAITO, K., TOSHIOKA, T. & HIDAKA, H. (1990). Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesised selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D Pheochromocytoma cells. J. Biol. Chem., 265, 5267-5272.
5. COSTA, E. & GUIDOTTI, A. (1996). Benzodiazepines on trial: a research strategy for their rehabilitation. Trends Pharmacol. Sci., 17, 192-200.
6. A subunit mRNA in rat brain. J. Mol. Neurosci., 2, 101-107.
7. A receptor subunit expression in rat neocortex during tolerance to diazepam. Mol. Pharmacol., 49, 822-831.
8. 1 protein is a sensitive indicator of benzodiazepine agonist efficacy. Eur. J. Pharmacol., 348, 321-324.
9. MOSS, S.J. & SMART, T.G. (1996). Modulation of amino acid-gated ion channels by protein phosphorylation. Int. Rev Neurobiol., 39, 1-52.
10. A receptor subunit protein and mRNA expression in rat cultured cerebellar granule cells. Br. J. Pharmacol., 119, 1393-1400.
11. A receptor subtypes. Pharmacol. Rev., 47, 181-234.
12. FOULLEC, D. PIANETTI, P. COSTE, H., BELLEVERGUE, P., GRANDPERRET, T., AJAKANES, M., BAUDET, V., BOISSIN, P., BOURSIER, E., LORIOLLE, E., DUHAMEL, L., CHARON, D. & KIRILOVSKY, J. (1991). The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J. Biol. Chem. 266, 15771-15781.