Glutamine: Is it a conditionally required nutrient for the human gastrointestinal system?

Journal of the American College of Nutrition

Volumn 15, Issue 3, 1996, Pages 199-205

  Buchman, Alan L ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CARBOHYDRATE; CD4 ANTIGEN; CD8 ANTIGEN; DISACCHARIDE; DNA; ELECTROLYTE; FLUOROURACIL; GLUTAMATE AMMONIA LIGASE; GLUTAMIC ACID; GLUTAMINE; GROWTH HORMONE; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; NITROGEN; PROTEIN; SODIUM; WATER; XYLOSE;

BACTERIUM; DIETARY FIBER; DIGESTIVE SYSTEM CANCER; GASTROINTESTINAL TRACT; HUMAN; IMMUNITY; INTESTINE MUCOSA PERMEABILITY; INTESTINE VILLUS; MUCOSA INFLAMMATION; NONHUMAN; NUTRIENT; PARENTERAL NUTRITION; REVIEW; SAFETY; SUPPLEMENTATION; TUMOR GROWTH;

ANIMALS; BACTERIAL TRANSLOCATION; ENTERAL NUTRITION; GLUTAMINE; HUMANS; INTESTINES; PARENTERAL NUTRITION, TOTAL; RATS;

EID: 0029895997     PISSN: 07315724     EISSN: 15411087     Source Type: Journal    
DOI: 10.1080/07315724.1996.10718590     Document Type: Article

References (76)

1. Windmueiler HG. Spteth AE: Identification of ketone bodies and glutamine as the major respiratory fuels in vivo for postabsorptive rat 5mall intestine. J Biol Chem 253:69-76, 1978.
2. Van de HulM RRWJ, Deuu SEP, Socten PB, Voo Meyenfeldt MF: Glutamine uptake at different sites of the human gut (Abstract). Clin Nutr 12;810-ll, 1993.
3. Scbcppach W. Loges C. Baruum P. Christl SO. Richter F. Dusel G. Stehle P: Effect of free glutamine and alanyl-glutamine dipeptide oq mucosal proliferation of the human ileum and colon Gauro enterology 107:429-434, 1994
4. Sitren HS. Bryant M, Elli LM: Specie* specific differences in TPN-induced intestinal villus atrophy (Abstract). /PEN 16:30S, 1992.
5. La J, Langkamp-Henken B, Suzuki K, Stahigren LH: Glutamine prevents parenteral nutritioo-ioduces incrcaic* in intestinal permeability JPEN 18:303-307, 1994.
6. Alverdy JC, Aoys E, Mocs GS: Total parenteral nutrition promotes bacterial translocatjoo from tbe gut Surgery 104:185-190, 1988.
7. Pappo I, Polachock I, Imora O, Feigm E, Freund HR: Altered gut barrier function to Candida during partcieraJ nutrition Nutrition 10:151-154, 1994
8. Jones WG, Minei JP, Barber AE, Rayburn JL, Fahey TJ, Shires GT, Shires GT: Bacterial traoslocation and intestinal atrophy after thermal injury and bum wound sepsis. Ann Surg 211:399-405, 1990.
9. Deitch EA The role of intestinal barrier failure and bacterial translocation in the development of systemic infection and multi pte organ failures. Arch Surg 125:403-404, 1990.
10. Plateli C, McCauley R, McCulloch R, Hall J The influence of parenteral glutamine and branched-chain amino acid acids cm total parenteral nutrition-induced atrophy of the gut. JPEN 17:348-354, 1993.
11. Ardawi MSM: Effect of glutamine-supplemented total parenteral nutrition on the small bowel of septic rats. Gin Nutr 11:207-215, 1992.
12. Tamada H. Nczu R. Imamura I, Matroo Y, Takagi Y, Kamau S, Okada A: The dipeptide alanyl-glutamine prevent* intestinal atrophy in parenterally fed rats. JPEN 16:110-116, 1992
13. O'Dwyer ST, Smith RJ, Hwang TL, Wilmore DW: Maintenance of small bowel mucosa with glutamine-enriched parenteral nutrition. JPEN 13:579-585, 1989
14. Inoque Y. Grant JP. Snyder PJ: Effect of glutamine-supplemented total parenteral nutrition on recovery of the small intestine after starvation atrophy. JPEN 17:165-170, 1993.
15. Czemichow B, Galluser M, Hasselnumn M, Doffoel M, Raul F: Effect of amino acids in mixtures given by enteral or parenteral route on intestinal morphology and hydrolase* in rau. JPEN 16: 259-263, 1992.
16. Hughes CA. Dowling RH: Speed of onset of adaptive mucosal hypoplasia and hypofunctxio in the intestine of parenterally fed rau. Clin Sci 59:317-327, 1980.
17. Goodlad RA. Lee CY. Wright NA: Ceil proliferation in the small intestine and coioa of intravenously fed rats: effects of urogas-trone-epidermal growth factor. Cell Prolif 25.393-404, 1992.
18. O'Dwyer ST. Smith RJ, Hwang TL, Wilmore DW; Maintenance of small bowel mucosa with glutamine-enriched parenteral nutrition. JPEN 13:579-585, 1989.
19. Castillo RO. Pittler A. Costa F: Intestinal maturation in the rat The role of enteral nutrients. JPEN 12:490-495, 1988.
20. Levine GM, Deren JJ, Steiger E, Zirjao R: Role of oral intake in maintenance of gut mass and disaccharxie activity. Gastroenterology 67:975-982, 1974.
21. Wusterman M, Tate H, Weaver L, Austin S, Neele G, Elia M: The effect of enteral glutamine deprivation and supplementation on the structure of rat small intestine mucosa during a systemic injury response JPEN 19:22-27, 1995
22. Jacobs DO, Evans D, Mealy K. O'Dwyer ST. Smith RJ. Wilmore DW: Combined effects of glutamine and epidermal grow* factor 00 the rat intestine. Surgery 104:358-364, 1988
23. Nussbaum M. McFadden D. Zhang FS. LaFnuice RJ, Daya R, Fischer JE: Addition of L-glutamine to total parenteral nutrition and its effects on portal insulin and glucagon and the development of hepatic steatosis in rats. J Surg Res 48:421-426, 1980
24. Grant JP, Snyder PJ: Use of glutamine in total parenteral nutrition J Surg Res 44:506-513, 1988.
25. Blomvigt BI. Hammarqvist F, von der Decken A, Wernermao I: Glutamine and alpha-ketogluUrate attenuate the fall in muscle free glutamine concentration after total hip replacement. Clin Nutr (supp) 12:12-13, 1993.
26. Parry-Billing** M. Baigrie RJ. Lamont PM. Morris PJ. Newiholrce EA: Effects of major and mi dot surgery oo plasma glutamine and cytokine levels. Arch Surg 127:1237-1240, 1992.
27. Planas M. Schwar US, Arbos MA, Farriol M: Plasma glutamine levels in septic patients JPEN 17:299-300, 1993
28. Wemcrman J. Haromarqvut F. All MR. Vinnars E: Glutamine and onuthiac-o-kctoglutarate but not branched-chain amino acids redute the lost of musele glutamine liter surgical trauma. Metabolism 18:63-66, 1989.
29. Parry-Billing*s M, Evans J, Calder PC, Newsholmc EA: Does glutamine contribute to immunosuppression after major bums? Lancet 336:523-525, 1990.
30. Hornsby-Lewis L, Shike M, Brown P, Klang M, Pearl stone D, Brennan MF: L-glutamine supplementation in home total parenteral nuUitioa patients: stability, safety, and effects an intestinal absorption JPEN 18:268-273, 1994
31. Byme TA, Morrissey TB, Ziegler TR, Gatzen C, Young LS, Wilmore DW: Growth hormone, glutamine, and fiber enhance adaptation of remnant bowel following massive intestinal resection Surg Forum 43:151-153, 1992.
32. Schlocrb PR, Amare M: Total parenteral nutrition with glutamine in bone marrow transplantation and other clinical applications JPEN 17:407-413, 1993.
33. Scbeltings MR. Young LS. Benfell K, Bye RL. Ziegler TR. Santos AA. An tin JH, Schlocrb PR. Wilmore DW: Glulamine-enncbed intravenous feedings attenuate extracellular fluid expansion after a standard sties*. Ann Surg 214:385-395, 1991.
34. Buchman AL. Moukaml AA, Bhuta S. Belle M, Ament ME. Eckbcrt CD. Hollander D, Gorobein J. Hopple JD. Vigayarogha-van SR: Parenteral nutntioo is associated with morphologic and functional changes in man. JPEN 19:453-460, 1995.
35. Van der Holst RRWJ, Deutt NEP, Von Meyenfeldt MF. Elber** JMH. Stockburgger RW. Soeten. PB: Decrease of mucosal glutamine concentration in the nutritionally depleted patient. Clin Nutr 13:228-233, 1994.
36. Allen SJ. Pietro A. Cope L. Macleod A. Howard CV, van Velze® D, Lloyd DA, Davidson DC: Giutamine-*upp leme rated parenteral nutrition in a child with short bowel xyndrocne. J Pediatr Gastroenterol Nutr 17:329-332, 1993.
37. Tremel H. Kienle B. Weilemann LS. Stchle P. Furst P: Glutamine dipeptide supplemented TPN maintains intestinal function in critically ill. Gastroenterology 107:1595-1601, 1994.
38. Van der Hulst RRWJ. von Meyenfeldt MF. van Kreel BK, Brum-rocr RJM. Arends JW. Deuti NEP, Soeters PB: Glutamine and the preservation of gut integrity. Lancet 341:1363-1365, 1993.
39. Wicks C, Somasundaram S, Bjamason I, Menzies IS, Routley D, Potter D, Tan KC, Williams R Comparison of enteral feeding and total parenteral nutrition after liver transplantation. lancet 344: 837-840, 1994
40. Ibarz M. Ayats J. Sancho JJ. Sitges-Serra A Primary bacteremias in critically ill trauma patients. Docs the route of nutrient intake make any difference? (Abstract). Clin Nutr I0(supp):34, 1991.
41. Sedman PC, Mactie J, Sagar P, Mitchell CJ, May J, Mancey-Jones B, Johnstone D: The prevalence of gut translocation in humans Gastroenterology 107:643-649, 1994
42. Reed L, Martin M, Hockman M, Kocka P, Manglano R, Barrett J: Bacterial translocation following abdominal trauma in humans (Abstract). Crit Care Med 19:S95, 1991.
43. Illig KA. Ryan CK. Hardy DJ. Rhodes J. Locke W. Sac HC: Total parenteral nutrition-induced changea in gut mucosal function: Atrophy aJooe is not the issue. Surgery 112:631-637, 1992
44. Burke DJ, Alverdy JC, Aoys E, Moss GS: Glutamine-supplemented total parenteral nutrition improves gut immune function. Arch Suxg 124:1396-1399, 1989.
45. Gianooi L. Alexander JW. Gcnnan R. Pyles T. Babcock GF: Oral glutamine decreases bacter.al tranilocation and improve* survival in experimental gut origin sepsis. JPEN 19:69-74, 1995.
46. Zapata Sirvent RL, Hansbrough JF, Ohara MM, Rice Asaro M, Nyhan WI.: Bacteria! translocation in burned mice after administration of various diet* including fiber-and gjulamine-enricbed enteral formulas. Crit Care Med 22:690-696, 1994.
47. Klimberg VS. Souba WW, Sitren H. Plummy DA. Salloum RM. Hxutamski D, Bland KI, Copeland EM: Glutamine-enriched total parenteral nutrition supports gut metabolism Surg Forum 40:175-176, 1989
48. Barba AE, Jones WG. Minei JP. Fahey TJ. Moldawer LL, Ray bum JL. Fischer E, Keogh C. Shires GT, Lowry SF: Glutamine on fiber supplementation of a defined formula diet: Impact on bacterial translocation. tissue composition, and response to endotoxin JPEN 14:335-343, 1990.
49. Alverdy JA. Aoys E. Weiss-Camngton P, Burke DA: The effect of glutamine-concbcd TPN on gut immune celiularity J Surg Re* 52:34-38, 1992.
50. Buchman AL, Moukarzel AA, Ament ME, Eckhert C, Bhuta S, Mcstecky J, Hollander D: Effects of total parenteral nutrition on iiuestinai morphology and function in humans. Transpl Proc 26 1457, 1994
51. Van der Hulst RRWJ. Von Meyenfeldt MF. Twbosch A. Buurman WA, Soeters PB: The effect of glutamine enriched parenteral nutrition on intestinal mucosa immune cells. (Abstract). Gastroenterology 106:636, 1994.
52. Ogle CK, Ogle JD. Mao JX, Simon J. Noel JG. Li BG. Alexander JW: Effect of glutamine on phagocytosis and bacienal killing by normal and ediatric bum patient neutrophils. JPEN 18:128-133, 1994.
53. Ziegler TR, Young LS, Benfell K, Scbeltings M. Hortos K, Bye R, Morrow FD. Jacobs DO. Smith RJ. An tin JH. Wilmore DW: Clinical and metabolic efficacy of glutamine supplemented paren teral nutrition after bone marrow transplantation. Ann Int Med 116:821-€28, 1992.
54. Diggory T. Sedman P, Sagai P, Mitchell CJ, Mac Fie J: Glutamine supplemented total parenteral nutrition (TPN) and bactenal turns location Nutrition 10:497, 1994.
55. Buchman AL, Mestecky J, Moukarzel A, Ament ME: Intestinal immune function is unaffected by parenteral nutrition in man. JACN 14(6):656-661, 1995.
56. Vac der Hnlst RRWJ, von Meyenfeldt MF, Tiebosch A, Buurman WA, Soeters PB: The effect of glutamine enricbcd parenteral nutrition on intestinal mucotal immune cell*. Clin Nutr 13(supp): 19-20, 1994
57. Klimberg VS. Souba WW, Dolson DJ. Salloum RM. Hautamaki RD. Plumlcy DA. Meodcnhall WM. Bova FJ, Khan SR. Hacked RL. Bland KJ. Copeland EM: Prophylactic glutamine protects the intestinal mucosa from radiation injury. Cancer 66:62-68, 1990.
58. Bark T, Svenberg T, Theodorssen E, Uribe A, Wennberg A: Glutamine supplementation docs not prevent small bowel mucosal atrophy after total parenteral nutrition in the rat. Clin Nutr 13:79-84, 1994.
59. Spaeth G, Gottwald T, Haas W, Holmer M: Gluunnine peptide docs not improve gut barrier function and mucosal immunity io total parenteral nutrition. JPEN 17:317-323, 1993.
60. Scon T. Moellman J: Intravenous glutamine supplementation fails to accetente gut mucosal rccowy following lOGy abdominal radiation, JPEN 15:J7S, 1991.
61. Fox AD, Kripke SA, Berman JR. Settle G, Rom beau JL: Reduction of the seventy of enterocolitis by glutamine supplemented entenU diet*. Surg Focum 38:43-44, 1987.
62. Horvath K. Janu M. Hill ID. Papadiimtrou J. Chanasongeram S, Lu RB, Lebentbal E: Short-term effect of a complete but glutamine-free oral diet on the small intestine. (Abstract). Gastroenterology 106.A610, 1994.
63. Karlstad M. Klindt R, Jooe J: Stimulation of intestinal epithelial cell production with glutamine enriched enteral nutrition in injured rats. (Abstract) FASEB J 5:A1724, 1991.
64. Vaoderhoff JA. Blackwood DJ. Mohammadpour BS. Park JHY: Effects of oral supplementation of glutamine on small intestinal mucosal mass following resection. J Am CoU Nutr 11.223-227, 1992.
65. Karatus T, Scopa S. Tsoni I, Panagopoulos K. Sptliopouiou I, Mcscbos S. Vagianc** K. KalfarenUos F: Effect of glutamine cm intestinal mucosal integrity and bacterial translocation after abdominal radiation. Clin Nutr 10:199-205, 1991.
66. Jacobs DO. Evans A. O'Dwyer ST. Smith RJ. Wilmore DW: Disparate effects of S-flurorouracil on the ileum and colon of enterally fed rats with protection by dietary glutamine. Surg Forum 38:45-47, 1987.
67. Bouteloup C, Decbelotte P, Hecketsweilei B, Michot F, Testart J, Lerebours E, Colin R: Effect of oral glutamine on absorptive function of ileostomised patients. (Abstract). Clin Nutr 13(supp): 61, 1994.
68. Ziegler TR, Benfeli K. Smith RJ. Young LS. Brown E, Ferrari-Balivien E. Lowe DK, Wilmocc DW: Safety and metabolic effects of L-glutamine administration in humans JPEN 14:137S-146S, 1990
69. Lowe DK. Benfeli K. Smith RJ, Jacobs DO. Murawski B. Ziegler TJ, Wilmore DW: Safety of glutamine-enriched parenteral nutrition soluUocu in humans. Am J Clin Nutr 52:1101-1106, 1990
70. Klimberg VS. Souba WW, Salloum RM. Fumley DA, Cohen FS, DoLsoo DJ, Bland KJ, Copeland EM: Glutamine-enriched diets support muscle glutamine metabolism without stimulating tumor growth. J Surg Res 48:319-323, 1990.
71. LeBricoo T. Cynober L. Banco** VE: Ornithine a-ketoglutaraie limits muscle protein breakdown without stimulating tumor growth in rats bearing Yoshida acites hepatoma Metabolism 43:899-905, 1994
72. Chance WT, Iequin C, Fischer JE: Response of tumor and host to hyperalimentation and antigiutamine treatments. JPEN 14:122-128, 1990.
73. Oppong K. Al-Mardini H. Thick M. Record O: Oral glutamine challenge in cirrhotics awaiting liver transplantation: A psychometric and analyzed EEG study. (Abstract). Gastroenterology 108: AU38, 1995.
74. Richard EW, Long CL, Pinkston JA, EUis V, Mostaghimi M, Gandy RE: The role of oral glutamine supplementation in the prevention of radiation-induced enterocolitis in prostate cancer patients (Abstract). FASEB J 6:AI680, 1992.
75. Jebb SA, Osborne RJ, Maugban TS, Mohideen N, Mack P, Mart D, Shelly MD, Elia M: S-fluorouracil and foliiuc acid-induced mucositis: no effect of oral glutamine supplementation. Br J Cancer 70:732-735, 1991
76. Daimiun D, Mesiing B, Ju B, Rongier M. Dejcux. JF: Cilu-?mine metabolism after small intestinal rcsectjoo io K?maus MeUbobwn 40:42-44, 1991.