Changes in cytokine levels during reactivation of Toxoplasma gondii infection in lungs

Infection and Immunity

Volumn 67, Issue 5, 1999, Pages 2082-2089

  Filice, Gregory A ^a,b   Clabots, Connie R ^a   Riciputi, Paul E ^a   Goñi Laguardia, Oscar ^a   Pomeroy, Claire ^a,b,c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS; INFLAMMATION; LUNG INFECTION; LUNG LAVAGE; MOUSE; NONHUMAN; PATHOGENESIS; PNEUMONIA; PRIORITY JOURNAL; TOXOPLASMA GONDII; TOXOPLASMOSIS;

EID: 0032902408     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.5.2082-2089.1999     Document Type: Article

References (42)

1. Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383:787-793.
2. Alford, C. J., S. Stagno, and D. W. Reynolds. 1974. Congenital toxoplasmosis: clinical, laboratory, and therapeutic considerations, with special reference to subclinical disease. Bull. N. Y. Acad. Med. 50:160-181.
3. Banister, S., and C. Pomeroy. 1993. Effect of ganciclovir on murine cytomegalovirus-induced reactivation of toxoplasma pneumonia. J. Lab. Clin. Med. 122:576-580.
4. Beaman, M. H., R. E. McCabe, S.-Y. Wong, and J. S. Remington. 1995. Toxoplasma gondii, p. 2455-2475. In G. Mandell, J. Bennett, and R. Dolin (ed.), Principles and practice of infectious diseases, 4th ed. Churchill Livingstone, New York, N.Y.
5. Choi, P., and H. Reiser. 1998. IL-4: role in disease and regulation of production. Clin. Exp. Immunol. 113:317-319.
6. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
7. Curtis, J. L., and H. B. Kaltreider. 1989. Characterization of bronchoalveolar lymphocytes during a specific antibody-forming cell response in the lungs of mice. Am. Rev. Respir. Dis. 139:393-400.
8. + effector function against intracellular infection. J. Exp. Med. 184:131-139.
9. de Vries, J. E. 1995. Immunosuppressive and anti-inflammatory properties of interleukin 10. Ann. Med. 27:537-541.
10. + T lymphocytes in IFN-γ production and protective immunity induced by an attenuated Toxoplasma gondii vaccine. J. Immunol. 146:286-292.
11. Gazzinelli, R. T., J. W. Hartley, T. N. Fredrickson, S. K. Chattopadhyay, A. Sher, and H. C. Morse III. 1992. Opportunistic infections and retrovirus-induced immunodeficiency: studies of acute and chronic infections with Toxoplasma gondii in mice infected with LP-BM5 murine leukemia viruses. Infect. Immun. 60:4394-4401.
12. + T cells and accompanied by overproduction of IL-12, IFN-γ and TNF-α. J. Immunol. 157:798-805.
13. Goetz, L., and C. Pomeroy. 1996. Impact of prophylactic ganciclovir on bronchoalveolar lavage lymphocyte numbers and phenotypes in murine cytomegalovirus-induced reactivation of Toxoplasma pneumonia. J. Lab. Clin. Med. 128:384-391.
14. + T helper type 2 T lymphocytes do not promote recovery from experimental virus infection. J. Exp. Med. 180:1273-1282.
15. + T cells from mice vaccinated against Toxoplasma gondii are cytotoxic for parasite-infected or antigen-pulsed host cells. J. Immunol. 147:2310-2316.
16. Haque, S., A. Haque, and L. H. Kasper. 1995. A Toxoplasma gondii-derived factor(s) stimulates immune downregulation: an in vitro model. Infect. Immun. 63:3442-3447.
17. Haque, S., I. Khan, A. Haque, and L. Kasper. 1994. Impairment of the cellular immune response in acute murine toxoplasmosis: regulation of interleukin 2 production and macrophage-mediated inhibitory effects. Infect. Immun. 62:2908-2916.
18. Hitt, J. A., and G. A. Filice. 1992. Detection of Toxoplasma gondii parasitemia by gene amplification cell culture and mouse inoculation. J. Clin. Microbiol. 30:3181-3184.
19. Hunter, C. A., J. S. Abrams, M. H. Beaman, and J. S. Remington. 1995. Cytokine mRNA in the central nervous system of SCID mice infected with Toxoplasma gondii: importance of T-cell-independent regulation of resis-tance to T. gondii. S. Immunol. 61:4038-4044.
20. Hunter, C. A., C. Subauste, V. Van Cleave, and J. S. Remington. 1994. Production of gamma interferon by natural killer cells from Toxoplasma gondii-infected SCID mice: regulation by interleukin-10, interleukin-12, and tumor necrosis factor alpha. Infect. Immun. 62:2818-2824.
21. Johnston, J. A., C. M. Bacon, M. C. Riedy, and J. J. O'Shea. 1996. Signaling by IL-2 and related cytokines: JAKs, STATs, and relationship to immunodeficiency. J. Leukoc. Biol. 60:441-452.
22. + T cell unresponsiveness during acute Toxoplasma gondii infection in mice. Int. Immunol. 8:887-896.
23. Khan, I. A., T. Matsuura, and L. H. Kasper. 1995. IL-10 mediates immunosuppression following primary infection with Toxoplasma gondii in mice. Parasite Immunol. 17:185-195.
24. Klemm, A., T. Tschernig, N. Krug, and R. Pabst. 1998. Lymphocyte subsets in distinct lung compartments show a different ability to produce interferon-gamma (IFN-γ) during a pulmonary immune response. Clin. Exp. Immunol. 113:252-257.
25. Moore, K., A. O'Garra, R. de Waal Malefyt, P. Vieira, and T. R. Mosmann. 1993. Interleukin-10. Annu. Rev. Immunol. 11:165-190.
26. Mosmann, T. R., L. Li, H. Hengartner, D. Kagi, W. Fu, and S. Sad. 1997. Differentiation and functions of T cell subsets. Ciba Found. Symp. 294: 148-158.
27. Pomeroy, C., and G. A. Filice. 1992. Pulmonary toxoplasmosis. Clin. Infect. Dis. 14:863-870.
28. Pomeroy, C., G. A. Filice, J. Hitt, and M. C. Jordan. 1992. Cytomegalovirus-induced reactivation of Toxoplasma gondii pneumonia in mice: lung lymphocyte phenotypes and suppressor function. J. Infect. Dis. 166:677-681.
29. Pomeroy, C., S. Kline, M. C. Jordan, and G. A. Filice. 1989. Reactivation of Toxoplasma gondii by cytomegalovirus disease in mice: antimicrobial activities of macrophages. J. Infect. Dis. 160:305-311.
30. Pomeroy, C., L. Miller, L. McFarling, C. Kennedy, and G. Filice. 1991 Phenotypes, proliferative responses and suppressor function of lung lymphocytes during Toxoplasma gondii pneumonia in mice. J. Infect. Dis. 164:1227-1232.
31. Reiner, S. L., and R. M. Locksley. 1995. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13:151-177.
32. Reiner, S. L., S. Zhen, D. B. Corry, and R. M. Locksley. 1993. Constructing polycompetitor cDNAs for quantitative PCR. J. Immunol. Methods 165: 37-46.
33. Remington, J. S., R. McLeod, and G. Desmonts. 1995. Toxoplasmosis, p. 140-267. In J. S. Remington and J. O. Klein (ed.), Infectious diseases of the fetus and newborn infant, 4th ed. The W. B. Saunders Co., Philadelphia, Pa.
34. + T cells secreting Th1 or Th2 cytokines. Immunity 2:271-279.
35. Scharton-Kersten, T., C. Contursi, A. Masumi, A. Sher, and K. Ozato. 1997. Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction. J. Exp. Med. 186:1523-1534.
36. Scharton-Kersten, T. M., T. A. Wynn, E. Y. Denkers, S. Bala, E. Grunvald, S. Hieny, R. T. Gazzinelli, and A. Sher. 1996. In the absence of endogenous IFN-γ, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection. J. Immunol. 157:4045-4054.
37. Sharma, S. D., J. M. Hofflin, and J. S. Remington. 1985. In vivo recombinant interleukin 2 administration enhances survival against a lethal challenge with Toxoplasma gondii. J. Immunol. 135:4160-4163.
38. Subauste, C. S., and J. S. Remington. 1991. Role of gamma interferon in Toxoplasma gondii infection. Eur. J. Clin. Microbiol. Infect. Dis. 10:58-67.
39. Suzuki, Y., F. K. Conley, and J. S. Remington. 1989. Importance of endogenous IFN-γ for prevention of toxoplasmic encephalitis in mice. J. Immunol. 143:2045-2050.
40. Suzuki, Y., F. K. Conley, and J. S. Remington. 1990. Treatment of toxoplasmic encephalitis in mice with recombinant gamma interferon. Infect. Immun. 58:3050-3055.
41. Suzuki, Y., M. A. Orellana, R. D. Schreiber, and J. S. Remington. 1988. Interferon-γ: the major mediator of resistance against Toxoplasma gondii. Science 240:516-518.
42. Yamamura, M., K. Uyemura, R. J. Deans, K. Weinberg, T. H. Rea, B. R. Bloom, and R. L. Modlin. 1991. Denning protective responses to pathogens: cytokine profiles in leprosy lesions. Science 254:277-279.