Functional analysis in vivo of the double mutant mouse deficient in both proteolipid protein (PLP) and myelin basic protein (MBP) in the central nervous system

Cell and Tissue Research

Volumn 289, Issue 2, 1997, Pages 195-206

  Stoffel, Wilhelm ^a,c   Boison, Detlev ^a   Büssow, Heinrich ^b  

^a Center of Biochemistry   (Germany)

^b Institute of Anatomy   (Germany)

^c UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Myelin basic protein; Myelination; PLP knockout mouse; Proteolipid protein; Pseudomyelin; Shiverer mouse

Indexed keywords

MYELIN ASSOCIATED GLYCOPROTEIN; MYELIN BASIC PROTEIN; PROTEOLIPID PROTEIN;

ARTICLE; CELL MEMBRANE; CENTRAL NERVOUS SYSTEM; MOUSE; MOUSE MUTANT; MYELINATION; NONHUMAN; OLIGODENDROGLIA; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL;

ANIMALS; CENTRAL NERVOUS SYSTEM; FEMALE; GALACTOSYLTRANSFERASES; GANGLIOSIDE GALACTOSYLTRANSFERASE; GENOTYPE; MALE; MICE; MICE, KNOCKOUT; MICROSCOPY; MICROSCOPY, ELECTRON; MUTATION; MYELIN BASIC PROTEINS; MYELIN PROTEOLIPID PROTEIN; MYELIN SHEATH; MYELIN-ASSOCIATED GLYCOPROTEIN; RNA;

EID: 0030850760     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004410050866     Document Type: Article

References (55)

1. Amor A, Baker D, Groome N, Turk JL (1993) Identification of a major encephalitogenic epitope of proteolipid protein (residues 56-70) for the induction of experimental allergic encephalomyelitis in Biozzi AB/H and nonobese diabetic mice. J Immunol 150:5666-5672
2. Arquint M, Roder J, Chia L-S, Down J, Wilkinson D, Bayley H, Braun P, Dunn R (1987) Molecular cloning and primary structure of myelin-associated glycoprotein. Proc Natl Acad Sci USA 84:600-604
3. Bird TD, Farrell DF, Sumi SM (1978) Brain lipid composition of the shiverer mouse (genetic defect in myelin development). J Neurochem 31:387-391
4. 75 → Pro) of the myelin proteolipid protein causes dysmyelination and oligodendrocyte death. EMBO J 8:3295-3302
5. Boison D, Stoffel W (1994) Disruption of the compacted myelin sheath of axons of the central nervous system in proteolipid protein-deficient mice. Proc Natl Acad Sci USA 91:11709-11713
6. Boison D, Büssow H, D'Urso D, Müller H-W, Stoffel W (1995) Adhesive properties of proteolipid protein are responsible for the compaction of CNS myelin sheaths. J Neurosci 15:5502-5513
7. Büssow H (1978) Schwann cell myelin ensheathing CNS axons in the nerve fibre layer of the cat retina. J Neurocytol 7:207-214
8. Carnegie PR (1971) Amino acid sequence of the basic protein of human brain myelin. Biochem J 122:65P
9. Chernoff GF (1981) Schiverer: an autosomal recessive mutant mouse with myelin deficiency. J Hered 72:128
10. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
11. Colman D, Kreibich G, Frey A, Sabatini D (1982) Synthesis and incorporation of myelin polypeptides into CNS myelin. J Cell Biol 95:598..608
12. Duncan I, Hammang J, Trapp B (1987) Abnormal compact myelin in the myelin-deficient rat: absence of proteolipid protein correlates with a defect in the intraperiod line. Proc Natl Acad Sci USA 84:6287-6291
13. Duncan ID, Hammang JP, Goda S, Quarles RH (1989) Myelination of the jimpy mouse in the absence of proteolipid protein. Glia 2:148-154
14. Edwards AM, Ross NW, Olmer JB, Braun PE (1989) Interaction of myelin basic protein and proteolipid protein. J Neurosci Res 22:97-102
15. Endoh M, Tabira T, Kunishita T, Sakai K, Yamamura T, Taketomi T (1986) DM-20, a proteolipid apoprotein, is an encephalitogen of acute and relapsing autoimmune encephalomyelitis in mice. J Immunol 137:3832-3835
16. Endoh M, Junishita T, Nihei J, Nishizawa M, Tabira T (1990) Susceptibilty to proteolipid apoprotein and its encephalitogenic determinants in mice. Int Arch Allergy Appl Immunol 92: 433-438
17. Folch J, Lee MB (1951) Proteolipides, a new type of tissue lipoproteins: their isolation from brain. J Biol Chem 191:807-817
18. Gow A, Friedrich VL, Lazzarini RA (1994) Many naturally occurring mutations of myelin proteolipid protein impair its intracellular transport. J Neurosci Res 37:574-583
19. Greer JM, Kuchroo VK, Sobel RA, Lees MB (1992) Identification and characterization of a second encephalitogenic determinant of myelin proteolipid protein (residues 178-191) for SJL mice. J Immunol 149:783-788
20. Harlow E, Lane D (1988) Immunoblotting. In: Antibodies. A laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, pp 471-510
21. Kagawa T, Ikenaka K, Inoue Y, Kuriyama S, Tsujii T, Nakao J, Nakajima K, Aruga J, Okano H, Mikoshiba K (1994) Glial cell degeneration and hypomyelination caused by overexpression of myelin proteolipid protein gene. Neuron 13:427-442
22. Kies MW (1965) Chemical studies on an encephalitogenic protein from guinea pig brain. Ann NY Acad Sci 122:161-170
23. Kies MW, Alvord EC (1959) Encephalitogenic activity in guinea pigs of water-soluble protein fractions of nervous tissue. In: Kies MW, Alvord EC (eds) "Allergic" encephalomyelitis. Thomas, Springfield, Ill., pp 293-299
24. Kies MW, Thompson EB, Alvord EC (1965) The relationship of myelin proteins to experimental allergic encephalomyelitis. Ann NY Acad Sci 122:148-160
25. Knapp P, Skoff R, Redstone D (1986) Oligodendroglial cell death in jimpy mice: an explanation for the myelin deficit. J Neurosci 6:2813-2822
26. Lees MB, Cambi F (1985) Noncontamination of proteolipid protein preparations by MBP. Ann Neurol 18:268
27. Linington C, Gunn CA, Lassmann H (1990) Identification of an encephalitogenic determinant of myelin proteolipid protein for the rabbit. J Neuroimmunol 30:135-144
28. Lumsden CE, Robertson DM, Blight R (1966) Chemical studies on experimental allergic encephalitogenic "antigens". J Neurochem 13:127-162
29. Molineaux SM, Engh H, Ferra F de, Hudson L, Lazzuarini R (1986) Recombination within the myelin basic protein gene created the dysmyelinating shiverer mouse mutation. Proc Natl Acad Sci USA 83:7542-7546
30. Morello D, Dautigny A, Pham-Dinh D, Jolies P (1986) Myelin proteolipid protein (PLP and DM-20) transcripts are deleted in jimpy mutant mice. EMBO J 5:3489-3493
31. Nadon NL, Duncan ID, Hudson LD (1990) A point mutation in the proteolipid protein gene of the "shaking pup" interrupts oligodendrocyte development. Development 110:529-537
32. Nave K, Lai C, Bloom F, Milner R (1986) Jimpy mutant mouse: A 74 base deletion in the mRNA for myelin proteolipid protein and evidence for a primary detect in RNA splicing. Proc Natl Acad Sci USA 83:9264-9268
33. Norton W, Poduslo S (1973) Myelination in rat brain: method of myelin isolation. J Neurochem 21:749-757
34. Omlin F, Webster H, Palkovits C, Cohen S (1982) Immunocytochemical localization of basic protein in major dense line regions of central and peripheral myelin. J Cell Biol 95:242-248
35. Privat A, Jacque C, Bourre JM, Bupouey P, Baumann N (1979) Absence of the major dense line in myelin of the mutant mouse "shiverer". Neurosci Lett 12:107-112
36. Readhead C, Schneider A, Griffiths I, Nave KA (1994) Premature arrest of myelin formation in transgenic mice with increased proteolipid protein gene dosage. Neuron 12:583-595
37. Roach A, Takahashi N, Pravtcheva D, Ruddie F, Hood L (1985) Chromosomal mapping of mouse myelin basic protein gene and structure and transcription of the partially deleted gene in shiverer mutant mice. Cell 42:149-155
38. Rosenbluth J (1980a) Peripheral myelin in the mouse mutant shiverer. J Comp Neurol 193:729-739
39. Rosenbluth J (1980b) Central myelin in the mouse mutant shiverer. J Comp Neurol 194:639-648
40. Satoh J, Sakai K, Endoh M, Koike F, Kunishita T, Namikawa T, Yamamura T, Tabira T (1987) Experimental allergic encephalomyelitis mediated by murine encephalitogenic T cell lines specific for myelin proteolipid apoprotein. J Immunol 138:179-184
41. Schulte S, Stoffel W (1993) Ceramide UDPgalactosyltransferase from myelinating rat brain: purification, cloning, and expression. Proc Natl Acad Sci USA 90:10265-10269
42. Sidman R (1964) Mutant mice (quaking and jimpy) with deficient myelination in the central nervous system. Science 144:309-311
43. Stoffel W, Hillen H, Schröder W, Deutzmann R (1983) The primary structure of bovine brain myelin lipophilin (proteolipid apoprotein). Hoppe-Seyler's Z Physiol Chem 364:1455-1466
44. Stoffel W, Hillen H, Giersiefen H (1984) Structure and molecular arrangement of proteolipid protein of central nervous system myelin. Proc Natl Acad Sci USA 81:5012-5016
45. Takahashi N, Roach A, Teplow DB, Prusiner SB, Hood L (1985) Cloning and characterization of the myelin basic protein gene from mouse: one gene can encode both 14 kd and 18.5 kd MBPs by alternate use of exons. Cell 42:139-148
46. Towbin H, Stachelin T, Gordon J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76:4350-4354
47. Trotter JL, Clark HB, Collins KG, Wegeschiede CL, Scarpellini JAD (1987) Myelin proteolipid protein induces demyelinating disease in mice. J Neurol Sci 79:173-188
48. Tuohy VK, Thomas DM (1993) A third encephalitogenic determinant of myelin proteolipid protein (PLP) for SJL/J mice. J Immunol 150:194A
49. Tuohy VK, Sobel RA, Lees MB (1988a) Myelin proteolipid protein-induced experimental allergic encephalomyelitis. Variations of disease expression in different strains of mice. J Immunol 140:1868-1873
50. Tuohy VK, Lu Z, Sobel RA, Laursen RA, Lees MB (1988b) A synthetic peptide from myelin proteolipid protein experimental allergic encephalomyelitis. J Immunol 141:1126-1130
51. Tuohy VK, Lu Z, Sobel RA, Laursen RA, Lees MB (1989) Idenficiation of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J Immunol 142:1523-1526
52. Tuohy VK. Sobel RA, Lu Z, Laursen RA, Lees MB (1992) Myelin proteolipid protein: minimum sequence requirements for active induction of autoimmune encephalomyelitis in SJL/J and SWR/J mice. J Neuroimmunol 39:67-74
53. Waxman SG, Black JA, Duncan ID, Ransom BR (1990) Macromolecular structure of axon membrane and action potential conduction in myelin deficient and myelin deficient heterozygote rat optic nerves. J Neurocytol 19:11-27
54. Weimbs T, Stoffel W (1992) Proteolipid protein (PLP) of CNS myelin: positions of free, disulfide bonded, and fatty acid thioester-linked cysteine residues. Implications for the membrane topology of PLP. Biochemistry 31:12289-12296
55. 1 mice. J Immunol 147:3803-3808