Frequent expansion of Epstein-Barr virus (EBV) infected cells in germinal centres of tonsils from an area with a high incidence of EBV- associated lymphoma

Journal of Pathology

Volumn 187, Issue 3, 1999, Pages 326-330

  Araujo, Iguaracyra ^a   Foss, Hans Dieter ^a   Hummel, Michael ^a   Anagnostopoulos, Ioannis ^a   Barbosa, Helenemarie S ^b   Bittencourt, Achilea ^b   Stein, Harald ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b Free University Berlin ^*

Author keywords

Epstein Barr virus; Germinal centres; In situ hybridization; Lymphoid tissue; Lymphoma; Tonsils

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; PROTEIN; SMALL NUCLEAR RNA;

ADOLESCENT; ARTICLE; BRAZIL; CHILD; DISEASE ASSOCIATION; EPSTEIN BARR VIRUS; GENE MUTATION; GENOTYPE; GERMANY; GERMINAL CENTER; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOHISTOLOGY; IN SITU HYBRIDIZATION; INCIDENCE; LYMPHOMA; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; TONSIL; VIRUS INFECTION;

ADOLESCENT; BRAZIL; CELL DIVISION; CHILD; CHILD, PRESCHOOL; DEVELOPING COUNTRIES; EPSTEIN-BARR VIRUS INFECTIONS; GERMINAL CENTER; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOENZYME TECHNIQUES; IN SITU HYBRIDIZATION; LYMPHOMA; RNA, VIRAL; TONSIL; VIRUS LATENCY;

EID: 0032895924     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199902)187:3<326::AID-PATH242>3.0.CO;2-N     Document Type: Article

References (25)

1. de-Thé G, Geser A, Day NE, et al. Epidemiological evidence for causal relationship between Epstein-Barr virus and Burkitt's lymphoma from Ugandan prospective study. Nature 1978; 274: 756.
2. Magrath I. The pathogenesis of Burkitt's lymphoma. Adv Cancer Res 1992; 55: 133.
3. Araujo I. Foss H-D, Bittencourt A. et al. Expression of Epstein-Barr virus gene products in Burkitt's lymphoma in northeast Brazil. Blood 1996; 87: 5279.
4. Hummel M, Anagnostopoulos I, Korbjuhn P, Stein H. Epstein-Barr virus in B cell non-Hodgkin's lymphomas: unexpected infection patterns and different infection incidence in low- and high-grade types. J Pathol 1995; 175: 263.
5. Hummel M, Anagnostopoulos I, Dallenbach F, Korbjuhn P, Dimmler C, Stein H. EBV infection patterns in Hodgkin's disease and normal lymphoid tissue: expression and cellular localization of EBV gene products. Br J Haematol 1992; 82: 689.
6. Chang KL, Albujar PF, Cher YY, Johnson RM, Weiss LM. High prevalence of Epstein Barr virus in the Reed Sternberg cells of Hodgkin's disease occurring in Peru. Blood 1993; 81: 496.
7. Weinreb M, Day PJ, Niggli F, et al. The consistent association between Epstein-Barr virus and Hodgkin's disease in children in Kenya. Blood 1996; 87: 3828.
8. Ambinder RF, Browning PJ, Lorenzana I, et al. Epstein Barr virus and childhood Hodgkin's disease in Honduras and the United States. Blood 1993;81:462.
9. H genes with a moderate number of antigen-selected somatic mutations. Am J Pathol 1995; 147: 1398.
10. H genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity. Blood 1995; 85:2176.
11. Tamaru J, Hummel M, Zemlin M, Kalvelage B, Stein H. Hodgkin's disease with a B-cell phenotype often shows a VDJ rearrangement and somatic mutations in the VH genes. Blood 1994; 84: 708.
12. Kanzler H, Kuppers R, Hansmann ML, Rajewsky K, Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal centre B cells. J Exp Med 1996; 184: 1495.
13. Niedobitek G, Herbst H, Young LS, et al. Patterns of Epstein-Barr virus infection in non-neoplastic lymphoid tissue. Blood 1992; 79: 2520.
14. Stein H, Gatter K, Asbar H, Mason DY. Use of freeze-dried paraffin-embedded sections for immunohistological staining with monoclonal antibodies. Lab Invest 1985; 52: 676.
15. Herbst H, Foss H-D, Samol J, et al. Frequent expression of interleukin-10 by Epstein-Barr virus-harboring tumor cells of Hodgkin's disease. Blood 1996; 87: 2918.
16. Anagnostopoulos I, Hummel M, Kreschel C, Stein H. Morphology, immunophenotype, and distribution of latently and/or productively Epstein-Barr virus-infected cells in acute infectious mononucleosis: implications for the inter-individual infection route of Epstein-Barr virus. Blood 1995; 85: 744.
17. Foss HD, Herbst H, Hummel M, et al. Patterns of cytokine gene expression in infectious mononucleosis. Blood 1994; 83: 707.
18. Clark EA, Ledbetter JA. How B and T cells talk to each other. Nature 1994; 367: 425.
19. Bittencourt AL, Barral-Netto M, Leishmaniasis. In: Doerr W, Seifert G, eds. Tropical Pathology. Berlin: Springer-Verlag, 1995, 597.
20. Andrade ZA, Abreu WN. Follicular lymphoma of the spleen in patients with hepatosplenic schistosomiasis mansoni. Am J Trop Med Hyg 1971; 20: 237.
21. Butch AW, Chung G-H, Hoffmann JW, Nahm MH. Cytokine expression by germinal center cells. J Immunol 1993; 150: 39.
22. Crawford DH, Thomas JA, Gregory CD, Catovsky D, Chaggar K. Induction of latent membrane protein expression in in vitro Epstein-Barr virus-infected leukaemic B lymphocytes by interleukin 4 and antibodies to CD40. Leukemia 1995: 747.
23. Pascual V, Liu YJ, Magalski A, de-Bouteiller O, Banchereau J, Capra JD. Analysis of somatic mutation in five B cell subsets of human tonsil. J Exp Med 1994; 180: 329.
24. Mosialos G, Birkenbach M, Yalamanchili R, VanArsdale T, Ware C, Kieff E. The Epstein-Barr virus transforming protein LMP-1 engages signalling proteins for the tumor necrosis factor receptor family. Cell 1995; 80: 389.
25. Kaye KM, Izumi KM, Kieff E. Epstein-Barr virus latent membrane protein is essential for B-lymphocyte growth transformation. Prof Natl Acad Sci USA 1993; 90: 9150.