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Volumn 33, Issue 3, 1999, Pages 325-339

Nelfinavir mesylate: A protease inhibitor

Author keywords

Human immunodeficiency virus; Nelfinavir mesylate

Indexed keywords

ANTIARRHYTHMIC AGENT; ANTICONVULSIVE AGENT; ANTIFUNGAL AGENT; ANTIMYCOBACTERIAL AGENT; BENZODIAZEPINE DERIVATIVE; DIDANOSINE; INDINAVIR; LAMIVUDINE; NELFINAVIR; RITONAVIR; SAQUINAVIR; STAVUDINE; ZIDOVUDINE;

EID: 0032895879     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.18089     Document Type: Review
Times cited : (74)

References (64)
  • 1
    • 0344624933 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention. HIV/AIDS Surveillance Report 1998;10(1).
    • (1998) HIV/AIDS Surveillance Report , vol.10 , Issue.1
  • 2
    • 0003176164 scopus 로고    scopus 로고
    • Report of the NIH panel to define principles of therapy of HIV infection and guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents
    • no. RR-5
    • Centers for Disease Control and Prevention. Report of the NIH Panel to define principles of therapy of HIV infection and guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents. MMWR Morb Mortal Wkly Rep 1998;47(no. RR-5).
    • (1998) MMWR Morb Mortal Wkly Rep , vol.47
  • 3
    • 0029155786 scopus 로고
    • Preformulation studies of a novel HIV protease inhibitor, AG1343
    • Longer M, Shetty B, Zamansky I, Tyle P. Preformulation studies of a novel HIV protease inhibitor, AG1343. J Pharm Sci 1995;84:1090-3.
    • (1995) J Pharm Sci , vol.84 , pp. 1090-1093
    • Longer, M.1    Shetty, B.2    Zamansky, I.3    Tyle, P.4
  • 4
    • 0025221948 scopus 로고
    • Human immunodeficiency virus protease: Target for AIDS therapy
    • Debouck C, Metcalf BW. Human immunodeficiency virus protease: target for AIDS therapy. Drug Dev Res 1990;21:1-17.
    • (1990) Drug Dev Res , vol.21 , pp. 1-17
    • Debouck, C.1    Metcalf, B.W.2
  • 5
    • 0025779083 scopus 로고
    • Target therapy of human immunodeficiency virus related disease
    • Mitsuya H, Yarchoan R, Kageyama S, Broder S. Target therapy of human immunodeficiency virus related disease. FASEB J 1990;5:2369-81.
    • (1990) FASEB J , vol.5 , pp. 2369-2381
    • Mitsuya, H.1    Yarchoan, R.2    Kageyama, S.3    Broder, S.4
  • 6
    • 0027413508 scopus 로고
    • HIV protease inhibitors: Their anti-HIV activity and potential role in treatment
    • Robins T, Plattner J. HIV protease inhibitors: their anti-HIV activity and potential role in treatment. J Acquir Immune Defic Syndr 1993;6:162-70.
    • (1993) J Acquir Immune Defic Syndr , vol.6 , pp. 162-170
    • Robins, T.1    Plattner, J.2
  • 8
    • 0024412506 scopus 로고
    • Conserved folding in retroviral proteases: Crystal structure of a synthetic HIV-1 protease
    • Wlodawer A, Miller M, Jaskolski M, Sathnarayana BK, Baldwin E, Weber IT, et al. Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease. Science 1989;245:616-21.
    • (1989) Science , vol.245 , pp. 616-621
    • Wlodawer, A.1    Miller, M.2    Jaskolski, M.3    Sathnarayana, B.K.4    Baldwin, E.5    Weber, I.T.6
  • 9
    • 13344275873 scopus 로고    scopus 로고
    • Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease
    • Patick AK, Mo H, Markowitz M, Appell K, Wu B, Musick L, et al. Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease. Antimicrob Agents Chemother 1996;40:292-7.
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 292-297
    • Patick, A.K.1    Mo, H.2    Markowitz, M.3    Appell, K.4    Wu, B.5    Musick, L.6
  • 10
    • 0026077832 scopus 로고
    • Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors
    • Nunberg JH, Sheif WA, Boots EJ, O'Brien JM, Quintero JC, Hoffmann JM, et al. Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors. J Virol 1991;65:4887-92.
    • (1991) J Virol , vol.65 , pp. 4887-4892
    • Nunberg, J.H.1    Sheif, W.A.2    Boots, E.J.3    O'Brien, J.M.4    Quintero, J.C.5    Hoffmann, J.M.6
  • 11
    • 0028013171 scopus 로고
    • Generation and characterization of human immunodeficiency virus type 1 (HIV-1) mutant resistant to an HIV-1 protease inhibitor
    • El-Farrash MA, Kuroda MJ, Kitazaki T, Masuda K, Kato K, Hatanaka M, et al. Generation and characterization of human immunodeficiency virus type 1 (HIV-1) mutant resistant to an HIV-1 protease inhibitor. J Virol 1994;68:233-9.
    • (1994) J Virol , vol.68 , pp. 233-239
    • El-Farrash, M.A.1    Kuroda, M.J.2    Kitazaki, T.3    Masuda, K.4    Kato, K.5    Hatanaka, M.6
  • 13
    • 0028843163 scopus 로고
    • Characterization of human immunodeficiency virus type 1 mutants with decreased sensitivity to proteinase inhibitor R031-8959
    • Jacobsen H, Yasargil K, Winslow DL, Craig JC, Krohn A, Duncan IB, et al. Characterization of human immunodeficiency virus type 1 mutants with decreased sensitivity to proteinase inhibitor R031-8959. Virology 1995;206:527-34.
    • (1995) Virology , vol.206 , pp. 527-534
    • Jacobsen, H.1    Yasargil, K.2    Winslow, D.L.3    Craig, J.C.4    Krohn, A.5    Duncan, I.B.6
  • 14
    • 0028286025 scopus 로고
    • Selection of multiple human immunodeficiency virus type 1 variants that encode viral proteases with decreased sensitivity to an inhibitor of the viral protease
    • Kaplan AH, Michael SF, Wehbie RS, Knigge MF, Paul DA, Everitt L, et al. Selection of multiple human immunodeficiency virus type 1 variants that encode viral proteases with decreased sensitivity to an inhibitor of the viral protease. Proc Natl Acad Sci USA 1994;91:5597-601.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 5597-5601
    • Kaplan, A.H.1    Michael, S.F.2    Wehbie, R.S.3    Knigge, M.F.4    Paul, D.A.5    Everitt, L.6
  • 15
    • 0028854676 scopus 로고
    • Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor
    • Markowitz M, Mo H, Kempf DJ, Norbeck DW, Bhat TN, Erickson JW, et al. Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor. J Virol 1995;69:701-6.
    • (1995) J Virol , vol.69 , pp. 701-706
    • Markowitz, M.1    Mo, H.2    Kempf, D.J.3    Norbeck, D.W.4    Bhat, T.N.5    Erickson, J.W.6
  • 16
    • 0027219220 scopus 로고
    • In vitro isolation and identification of human immunodeficiency virus (HIV) variants with reduced sensitivity to C-2 symmetrical inhibitor of HIV type 1 protease
    • Otto MJ, Garber S, Winslow DL, Reid CD, Aldrich P, Jadhav PK, et al. In vitro isolation and identification of human immunodeficiency virus (HIV) variants with reduced sensitivity to C-2 symmetrical inhibitor of HIV type 1 protease. Proc Natl Acad Sci U S A 1993;90:7543-7.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 7543-7547
    • Otto, M.J.1    Garber, S.2    Winslow, D.L.3    Reid, C.D.4    Aldrich, P.5    Jadhav, P.K.6
  • 17
  • 18
    • 0028949246 scopus 로고
    • Characterization of a human immunodeficiency virus type 1 variant with reduced sensitivity to an aminodiol protease inhibitor
    • Patick AK, Rose R, Greytok J, Bechtold CM, Hermsmeier MA, Chen PT, et al. Characterization of a human immunodeficiency virus type 1 variant with reduced sensitivity to an aminodiol protease inhibitor. J Virol 1995;69:2148-52.
    • (1995) J Virol , vol.69 , pp. 2148-2152
    • Patick, A.K.1    Rose, R.2    Greytok, J.3    Bechtold, C.M.4    Hermsmeier, M.A.5    Chen, P.T.6
  • 19
    • 0345561021 scopus 로고
    • In vitro selection and characterization of human immunodeficiency virus type 1 (HIV-1) variants with decreased sensitivity to hydroxyethylurea isostere containing protease inhibitors
    • London
    • Potts KE, Smidt ML, Stallings WC Jr, Clare M, Pillay D, Richman DD, et al. In vitro selection and characterization of human immunodeficiency virus type 1 (HIV-1) variants with decreased sensitivity to hydroxyethylurea isostere containing protease inhibitors. 3rd International Workshop on HIV Drug Resistance, London, 1994.
    • (1994) 3rd International Workshop on HIV Drug Resistance
    • Potts, K.E.1    Smidt, M.L.2    Stallings W.C., Jr.3    Clare, M.4    Pillay, D.5    Richman, D.D.6
  • 22
    • 0029964107 scopus 로고    scopus 로고
    • Current knowledge and future prospects for the use of HIV protease inhibitors
    • Moyle G, Gazzard B. Current knowledge and future prospects for the use of HIV protease inhibitors. Drugs 1996;51(5):701-12.
    • (1996) Drugs , vol.51 , Issue.5 , pp. 701-712
    • Moyle, G.1    Gazzard, B.2
  • 23
    • 0344624641 scopus 로고    scopus 로고
    • Viral load and genotypic resistance pattern in HIV-1 infected patients treated by a triple combination therapy including nucleoside and protease inhibitors initiated at primary infection
    • Washington, DC, January
    • Tamlet C, Poizot Martin IP, Lafeuillade A, Yahi N, Vigne R, Eissot Dupont H, et al. Viral load and genotypic resistance pattern in HIV-1 infected patients treated by a triple combination therapy including nucleoside and protease inhibitors initiated at primary infection. 4th Conference on Retroviruses and Opportunistic Infections, Washington, DC, January 22-26, 1997.
    • (1997) 4th Conference on Retroviruses and Opportunistic Infections , pp. 22-26
    • Tamlet, C.1    Poizot Martin, I.P.2    Lafeuillade, A.3    Yahi, N.4    Vigne, R.5    Eissot Dupont, H.6
  • 25
    • 0342323915 scopus 로고    scopus 로고
    • A randomized phase II dose range-finding study of the HIV protease inhibitor Viracept as monotherapy in HIV positive patients
    • Vancouver, BC, Canada, July 7-12
    • Conant M, Markowitz M, Hurley A, Ho D, Peterkin J, Chapman S. A randomized Phase II dose range-finding study of the HIV protease inhibitor Viracept as monotherapy in HIV positive patients. XI International Conference on AIDS, Vancouver, BC, Canada, July 7-12, 1996.
    • (1996) XI International Conference on AIDS
    • Conant, M.1    Markowitz, M.2    Hurley, A.3    Ho, D.4    Peterkin, J.5    Chapman, S.6
  • 26
    • 12644277366 scopus 로고    scopus 로고
    • Genotypic analysis of HIV-1 variants isolated from patients with the protease inhibitor nelfinavir, alone or in combination with stavudine or zidovudine and lamivudine
    • Washington, DC, January 22-26
    • Patick AK, Duran M, Cao Y, Ho T, Zhou P, Keller MR, et al. Genotypic analysis of HIV-1 variants isolated from patients with the protease inhibitor nelfinavir, alone or in combination with stavudine or zidovudine and lamivudine. 4th Conference on Retroviruses and Opportunistic Infections, Washington, DC, January 22-26, 1997.
    • (1997) 4th Conference on Retroviruses and Opportunistic Infections
    • Patick, A.K.1    Duran, M.2    Cao, Y.3    Ho, T.4    Zhou, P.5    Keller, M.R.6
  • 28
    • 0344192886 scopus 로고
    • Phase i safety, tolerance, pharmacokinetics and food effect studies of AG1343 - A novel HIV protease inhibitor
    • Washington, DC, January 29-February 2
    • Quart BD, Chapman SK, Peterkin J, Webber S, Oliver S. Phase I safety, tolerance, pharmacokinetics and food effect studies of AG1343 - a novel HIV protease inhibitor. 2nd National Conference on Human Retrovirus, Washington, DC, January 29-February 2, 1995.
    • (1995) 2nd National Conference on Human Retrovirus
    • Quart, B.D.1    Chapman, S.K.2    Peterkin, J.3    Webber, S.4    Oliver, S.5
  • 29
    • 0030032764 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics and distribution to tissue of AG1343, an inhibitor of human immunodeficiency virus type 1 protease
    • Shetty BV, Kosa MB, Khalil DA, Webber S. Preclinical pharmacokinetics and distribution to tissue of AG1343, an inhibitor of human immunodeficiency virus type 1 protease. Antimicrob Agents Chemother 1996; 40:110-4.
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 110-114
    • Shetty, B.V.1    Kosa, M.B.2    Khalil, D.A.3    Webber, S.4
  • 32
    • 0345541901 scopus 로고    scopus 로고
    • La Jolla, CA: Agouron Pharmaceuticals, Inc.
    • Data submitted to Department of Health and Human Services for NDA approval. Viracept (nelfinavir). La Jolla, CA: Agouron Pharmaceuticals, Inc., 1997.
    • (1997) Viracept (Nelfinavir)
  • 34
    • 0005514294 scopus 로고    scopus 로고
    • The efficacy of Viracept (nelfinavir mesylate, NFV) in pivotal phase II/III double blind randomized controlled trials as monotherapy and in combination with stavudine or zidovudine/lamivudine
    • Washington, DC, January 22-26
    • Powderly W, Sension M, Conant M, Stein A, Clendeninn N. The efficacy of Viracept (nelfinavir mesylate, NFV) in pivotal Phase II/III double blind randomized controlled trials as monotherapy and in combination with stavudine or zidovudine/lamivudine. 4th Conference on Retroviruses and Opportunistic Infections, Washington, DC, January 22-26, 1997.
    • (1997) 4th Conference on Retroviruses and Opportunistic Infections
    • Powderly, W.1    Sension, M.2    Conant, M.3    Stein, A.4    Clendeninn, N.5
  • 35
    • 0003244062 scopus 로고    scopus 로고
    • The safety of Viracept (nelfinavir mesylate, NFV) in pivotal Phase II/III double-blind randomized controlled trials as monotherapy and in combination with either stavudine or zidovudine/lamivudine
    • Washington, DC, January 22-26
    • Henry K, Lamarca A, Myers R, Chapman S. The safety of Viracept (nelfinavir mesylate, NFV) in pivotal Phase II/III double-blind randomized controlled trials as monotherapy and in combination with either stavudine or zidovudine/lamivudine. 4th Conference on Retroviruses and Opportunistic Infections, Washington, DC, January 22-26, 1997.
    • (1997) 4th Conference on Retroviruses and Opportunistic Infections
    • Henry, K.1    Lamarca, A.2    Myers, R.3    Chapman, S.4
  • 37
    • 0013538264 scopus 로고    scopus 로고
    • Triple therapy with zidovudine and lamivudine in combination with nelfinavir mesylate in 12 antiretroviral-naïve subjects chronically infected with HIV-1
    • Vancouver, BC, Canada, July 7-12
    • Markowitz M, Cao Y, Hurley A, O'Donovan R, Peterkin J, Anderson B, et al. Triple therapy with zidovudine and lamivudine in combination with nelfinavir mesylate in 12 antiretroviral-naïve subjects chronically infected with HIV-1. XI International Conference on AIDS, Vancouver, BC, Canada, July 7-12, 1996.
    • (1996) XI International Conference on AIDS
    • Markowitz, M.1    Cao, Y.2    Hurley, A.3    O'Donovan, R.4    Peterkin, J.5    Anderson, B.6
  • 38
    • 0343960770 scopus 로고    scopus 로고
    • A pilot study of safety and antiviral activity of the combination of stavudine, didanosine and nelfinavir in HIV-infected subjects
    • Pedneault L, Elion R, Adler M, Anderson R, Mohanty S, Knupp C, et al. A pilot study of safety and antiviral activity of the combination of stavudine, didanosine and nelfinavir in HIV-infected subjects (abstract). AIDS 1996;10(suppl 2):S17.
    • (1996) AIDS , vol.10 , Issue.SUPPL. 2
    • Pedneault, L.1    Elion, R.2    Adler, M.3    Anderson, R.4    Mohanty, S.5    Knupp, C.6
  • 39
    • 0343964167 scopus 로고    scopus 로고
    • Stavudine (d4T), didanosine (ddI), and nelfinavir combination therapy in HIV-infected subjects: Antiviral effect and safety in an ongoing pilot study
    • Washington, DC, January 22-26
    • Pedneault L, Elion R, Adler M, Anderson R, Kelleher T, Knupp C, et al. Stavudine (d4T), didanosine (ddI), and nelfinavir combination therapy in HIV-infected subjects: antiviral effect and safety in an ongoing pilot study. 4th Conference on Retroviruses and Opportunistic Infections, Washington, DC, January 22-26, 1997.
    • (1997) 4th Conference on Retroviruses and Opportunistic Infections
    • Pedneault, L.1    Elion, R.2    Adler, M.3    Anderson, R.4    Kelleher, T.5    Knupp, C.6
  • 42
    • 0003311729 scopus 로고    scopus 로고
    • Study of protease inhibitor combination in Europe (SPICE): Saquinavir soft gelatin capsule (SQV-SGC) and nelfinavir in HIV infected individuals
    • Chicago, February 1-5
    • Opravil M on behalf of the SPICE study team. Study of Protease Inhibitor Combination in Europe (SPICE): saquinavir soft gelatin capsule (SQV-SGC) and nelfinavir in HIV infected individuals. 5th Conference on Retroviruses and Opportunistic Infections, Chicago, February 1-5, 1998.
    • (1998) 5th Conference on Retroviruses and Opportunistic Infections
  • 45
    • 0008158938 scopus 로고    scopus 로고
    • Open label pilot study to assess the safety and efficacy of bid dosing regimens of Viracept (nelfnavir mesylate) combined with NRTI's in HIV-infected treatment-naïve patients
    • Chicago, February 1-5
    • Sension M, Elion R, Farthing C, Currier J, Lindquist B, Richardson B, et al. Open label pilot study to assess the safety and efficacy of bid dosing regimens of Viracept (nelfnavir mesylate) combined with NRTI's in HIV-infected treatment-naïve patients. 5th Conference on Retroviruses and Opportunistic Infections, Chicago, February 1-5, 1998.
    • (1998) 5th Conference on Retroviruses and Opportunistic Infections
    • Sension, M.1    Elion, R.2    Farthing, C.3    Currier, J.4    Lindquist, B.5    Richardson, B.6
  • 46
    • 0003979209 scopus 로고    scopus 로고
    • La Jolla, CA: Agouron Pharmaceuticals, Inc.
    • Data on file. La Jolla, CA: Agouron Pharmaceuticals, Inc., 1997.
    • (1997) Data on File
  • 49
    • 0345055104 scopus 로고    scopus 로고
    • Early CD4, viral load and quality of life response to salvage treatment with nelfinavir: The USCD Owen Clinic Nelfinavir Expanded Access Experience
    • Chicago, February 1-5
    • Ballard C, Toerner JG, Colwell B, Mathews WC. Early CD4, viral load and quality of life response to salvage treatment with nelfinavir: the USCD Owen Clinic Nelfinavir Expanded Access Experience. 5th Conference on Retroviruses and Opportunistic Infections, Chicago, February 1-5, 1998.
    • (1998) 5th Conference on Retroviruses and Opportunistic Infections
    • Ballard, C.1    Toerner, J.G.2    Colwell, B.3    Mathews, W.C.4
  • 50
    • 0344624634 scopus 로고    scopus 로고
    • Increased incidence of bleeding episodes in persons with hemophilia in association with protease inhibitor antiretroviral therapy
    • Ottawa, ON, Canada, May 22-25
    • Tsoukas C, Belanger G, Bond M. Increased incidence of bleeding episodes in persons with hemophilia in association with protease inhibitor antiretroviral therapy. Canadian Conference of HIV/AIDS Research, Ottawa, ON, Canada, May 22-25, 1997.
    • (1997) Canadian Conference of HIV/AIDS Research
    • Tsoukas, C.1    Belanger, G.2    Bond, M.3
  • 57
    • 0032551258 scopus 로고    scopus 로고
    • Pathogenesis of HIV-1 protease inhibitor-associated peripheral lipodystrophy, hyperlipidemia, and insulin resistance
    • Carr A, Samaras K, Burton S, Chishsolm DJ, Cooper DA. Pathogenesis of HIV-1 protease inhibitor-associated peripheral lipodystrophy, hyperlipidemia, and insulin resistance. Lancet 1998;351:1881-3.
    • (1998) Lancet , vol.351 , pp. 1881-1883
    • Carr, A.1    Samaras, K.2    Burton, S.3    Chishsolm, D.J.4    Cooper, D.A.5
  • 58
    • 0007561021 scopus 로고    scopus 로고
    • Co-administration of indinavir (IDV) and nelfinavir (NFV) in a twice daily regimen: Preliminary safety, pharmacokinetic and anti-viral activity results
    • Chicago, February 1-5
    • Havlir D, Riddler S, Squires K, Winslow D, Kerr B, Nguyen B, et al. Co-administration of indinavir (IDV) and nelfinavir (NFV) in a twice daily regimen: preliminary safety, pharmacokinetic and anti-viral activity results. 5th Conference on Retroviruses and Opportunistic Infections, Chicago, February 1-5, 1998.
    • (1998) 5th Conference on Retroviruses and Opportunistic Infections
    • Havlir, D.1    Riddler, S.2    Squires, K.3    Winslow, D.4    Kerr, B.5    Nguyen, B.6
  • 61
    • 0032500114 scopus 로고    scopus 로고
    • Lack of pharmacokinetic interaction between nelfinavir and nevirapine
    • Skowron G, Leoung G, Kerr B, Dusek A, Anderson R, Beebe S, et al. Lack of pharmacokinetic interaction between nelfinavir and nevirapine. AIDS 1998;12:1243-4.
    • (1998) AIDS , vol.12 , pp. 1243-1244
    • Skowron, G.1    Leoung, G.2    Kerr, B.3    Dusek, A.4    Anderson, R.5    Beebe, S.6
  • 64
    • 0003855207 scopus 로고    scopus 로고
    • Montvale, NJ: Medical Economics Co., Inc.
    • 1998 Drug topics red book. Montvale, NJ: Medical Economics Co., Inc., 1998:590.
    • (1998) 1998 Drug Topics Red Book. , pp. 590


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