Effects of glycine antagonists in an acute in vitro electrophysiological model of ischemia

Drug Development Research

Volumn 46, Issue 2, 1999, Pages 134-138

  Schilp, Donald E ^a   Sorensen, Stephen M ^a   Wettstein, Joseph G ^a   Black, Mark D ^a  

^a SANOFI   (France)

Author keywords

Hippocampus; In vitro electrophysiology; Neuroprotection; Rat; Stroke

Indexed keywords

6,7 DICHLORO 5 NITRO 2,3 QUINOXALINEDIONE; 7 CHLORO 4 HYDROXY 3 (3 PHENOXYPHENYL) 2 QUINOLONE; DIZOCILPINE; GAVESTINEL; GLYCINE RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN SLICE; CONTROLLED STUDY; DRUG EFFECT; ELECTROPHYSIOLOGY; HIPPOCAMPUS; IN VITRO STUDY; ISCHEMIA; MALE; NEUROPROTECTION; NONHUMAN; RAT; STROKE;

EID: 0032890609     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2299(199902)46:2<134::AID-DDR6>3.0.CO;2-9     Document Type: Article

References (24)

1. Aitken PG, Schiff SJ. 1986. Barbiturate protection against hypoxic neuronal damage in vitro. J Neurosurg 65:230-232.
2. Aitken PG, Balestrino M, Somjen GG. 1988. NMDA antagonists: lack of protective effect against hypoxic damage in CA1 region of hippocampal slices. Neurosci Lett 89:187-192.
3. Andreasen M, Lambert JD, Jensen MS. 1989. Effects of new non-N-methyl-D-apartate antagonists on synaptic transmission in them vitro rat hippocampus. J Physiol 414:317-336.
4. Astrup J, Siesjo BK, Symon L. 1981. Thresholds in cerebral ischemia: the ischemic penumbra. Stroke 12:723-725.
5. Balestrino MJ. 1995. Pathophysiology of anoxic depolarization: new findings and a working hypothesis. Neurosci Methods 59:99-103.
6. Balestrino M, Somjen GG. 1986. Chlorpromazine protects brain tissue in hypoxia by delaying spreading depression-mediated calcium influx. Brain Res 385:219-226.
7. Bordi F, Pietra C, Ziviani L, Reggiani A. 1997. The glycine antagonist GV150526 protects somatosensory evoked potentials and reduces the infarct area in the MCAo model of focal ischemia in the rat. Exp Neurol 145:425-433.
8. Dong WQ, Schurr A, Reid KH, Shields CB, West CA. 1988. The rat hippocampal slice preparation as an in vitro model of ischemia. Stroke 19:498-502.
9. Dorrmann PJ, Counsell CE, Sandercock AG. 1996. Recently developed neuroprotective therapies for acute stroke. Pharmacol Pathophys 5:457-474.
10. Fabio RD, Cugola A, Donati D, Feriani A, Gaviraghi G, Ratti E, Trist DG, Reggiani A. 1998. Identification and pharmacological characterization of GV150526, a novel glycine antagonist as a potent neuroprotective agent. Drugs Future 23:61-69.
11. + flux and the anoxic depolarization to adenosine 5'-triphosphate levels in hypoxic/hypoglycemic rat hippocampal slices. Neuroscience 83:717-722.
12. Fried E, Amorim P, Chambers G, Cottrell JE, Kass IS. 1995. The importance of sodium for anoxic transmission damage in rat hippocampal slices: mechanisms of protection by lidocaine. J Physiol 489:557-565.
13. Johnson JW, Ascher P. 1987. Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 325:529-531.
14. Kass IS, Lipton P. 1982. Mechanisms involved in irreversible anoxic damage to the in vitro rat hippocampal slice. J Physiol 332:459-472.
15. Koroshetz WJ, Moskowitz MA. 1996. Emerging treatments for stroke in humans. Trends Pharmacol Sci 17:227-233.
16. Kretschmer BD, Kratzer U, Breithecker K, Koch M. 1997. ACEA 1021, a glycine site antagonist with minor psychotomimetic and amnestic effects in rats. Eur J Pharmacol 331:109-116.
17. Lingenhöhl K, Pozza ME 1998. Reevaluation of ACEA 1021 as an antagonist at the strychnine-insensitive glycine site of the N-methyl-D-aspartate receptor. Neuropharmacology 37:729-737.
18. Opitz T, Richter P, Carter AJ, Kozikowski AP, Shinozaki H, Reymann KG. 1995. Metabotropic glutamate receptor subtypes differentially influence neuronal recovery from in vitro hypoxia/hypoglycemia in rat hippocampal slices. Neuroscience 68:989-1001.
19. Park CK, Nehls DG, Graham DI, Teasdale GM, McCulloch J. 1988. The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat. Ann Neurol 24:543-551.
20. Park CK, McCulloch J, Kang JK,Choi CR. 1992. Efficacy of D-CPPene, a competitive N-methyl-D-aspartate antagonist in focal cerebral ischemia in the rat. Neurosci Let t147:41-44.
21. Qiu H, Hedlund LW, Gewalt SL, Benveniste H, Bare TM, Johnson GA. 1997. Progression of a focal ischemic lesion in rat brain during treatment with a novel glycine/NMDA antagonist: an in vivo three-dimensional diffusion-weighted MR microscopy study. J Magn Reson Imaging 7:739-744.
22. Schurr A, Payne RS, Rigor BM. 1995. Synergism between diltiazem and MK-801 but not APV in protecting hippocampal slices against hypoxic damage. Brain Res 684:233-236.
23. Warner DS, Martin H, Ludwig P, McAllister A, Keana J, Weber E. 1995. In vivo models of cerebral ischemia: effects of parenterally administered NMDA receptor glycine site antagonist. J Cereb Blood Flow Metab 15:188-196.
24. Woodward RM, Huettner JE, Guastella J. 1995. In vitro pharmacology of ACEA-1021 and ACEA-1031: systemically active quinoxalinediones with high affinity and selectivity for N-methyl-D-aspartate receptor glycine sites. Mol Pharmacol 47:568-581.