PR-39, a proline/arginine-rich antimicrobial peptide, prevents postischemic microvascular dysfunction

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 277, Issue 3 46-3, 1999, Pages

  Korthuis, Ronald J ^a   Gute, Dean C ^b   Blecha, Frank ^b   Ross, Chris R ^b  

^a LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

^b NONE

Author keywords

Intercellular adhesion molecule 1; Intravital microscopy; Leukocyte adhesion; Leukocyte emigration; Oxidant production; Venular protein leakage

Indexed keywords

ANTIINFECTIVE AGENT; PEPTIDE DERIVATIVE; PHORBOL 13 ACETATE 12 MYRISTATE; PR 39; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; IMMUNOMODULATION; INTESTINE ISCHEMIA; INTRAVENOUS DRUG ADMINISTRATION; LEUKOCYTE ACTIVATION; LEUKOCYTE ADHERENCE; LEUKOCYTE MIGRATION INHIBITION; MALE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

EID: 0032885893     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1999.277.3.h1007     Document Type: Article

References (20)

1. Akimitsu, T., D. C. Gute, and R. J. Korthuis. Ischemic preconditioning attenuates postischemic leukocyte adhesion and emigration. Am. J. Physiol. 271 (Heart Circ. Physiol. 40): H2052-H2059, 1996.
2. +. Circ. Res. 83: 730-737, 1998.
3. Cas. J. Biol. Chem. 273: 28978-28985, 1998.
4. Collins, T., M. Read, A. Neish, M. Whitley, D. Thanos, and T. Maniatis. Transcriptional regulation of endothelial cell adhesion molecules: NF-κB and cytokine-inducible enhancers. FASEB J. 9: 899-909, 1995.
5. Clark, W., and W. Nauseef. Isolation and functional analysis of neutrophils. In: Current Protocols in Immunology, edited by J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober. New York: Wiley, 1999.
6. 2 receptors (Abstract). Microcirculation 3: 38, 1996.
7. Gute, D., and R. J. Korthuis. Role of leukocyte adherence in reperfusion-induced microvascular dysfunction and tissue injury. In: Physiology and Pathophysiology of Leukocyte Adhesion, edited by D. N. Granger and G. W. Schmid-Schonbein. New York: Oxford, 1995, p. 359-380.
8. Granger, D. N., and R. J. Korthuis. Physiologic mechanisms of postischemic tissue injury. Annu. Rev. Physiol. 57: 311-332, 1995.
9. Huang, H.-J., C. R. Ross, and F. Blecha. Chemoattractant properties of PR-39, a neutrophil antibacterial peptide. J. Leukoc. Biol. 61: 624-629, 1997.
10. Jones, S., V. O'Donnell, J. Wood, J. Broughton, E. Hughes, O. Jones. Expression of phagocyte NADPH oxidase components in human endothelial cells. Am. J. Physiol. 271 (Heart Circ. Physiol. 40): H1626-H1634, 1996.
11. Kitayama, J., M. Carr, S. Roth, J. Buccola, and T. Springer. Contrasting responses to multiple chemotactic stimuli in transendothelial migration. J. Immunol. 158: 2340-2349, 1997.
12. Kupatt, C., C. Weber, D. Wolf, B. Becker, T. Smith, and R. Kelly. Nitric oxide attenuates reoxygenation-induced ICAM-1 expression in coronary microvascular endothelium: role of NF-κB. J. Mol. Cell. Cardiol. 29: 2599-2609, 1997.
13. Kurose, I., P. Kubes, R. Wolf, D. C. Anderson, J. Paulson, M. Miyasaka, and D. N. Granger. Inhibition of nitric oxide production: mechanisms of vascular albumin leakage. Circ. Res. 73: 164-171, 1993.
14. Panes, J., and D. N. Granger. Leukocyte-endothelial cell interactions: molecular mechanisms and implications in gastrointestinal disease. Gastroenterology 114: 1066-1090, 1998.
15. Panes, J., I. Kurose, D. Rodriguez-Vaca, D. C. Anderson, M. Miyasaka, P. Tso, and D. N. Granger. Diabetes exacerbates inflammatory responses to ischemia-reperfusion. Circulation 93: 161-167, 1996.
16. Shi, J., C. R. Ross, M. M. Chengappa, and F. Blecha. Identification of a proline-arginine-rich antibacterial peptide from neutrophils that is analogous to PR-39, an antibacterial peptide from the small intestine. J. Leukoc. Biol. 56: 807-811, 1994.
17. phox. Proc. Natl. Acad. Sci. USA 93: 6014-6018, 1996.
18. Smith, C. W., S. Marlin, R. Rothlein, C. Toman, and D.C. Anderson. Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro. J. Clin. Invest. 83: 2008-2017, 1989.
19. Smith, C. W., R. Rothlein, B. J. Hughes, M. M. Mariscalco, H. E. Rudloff, F. C. Schmalstieg, and D. C. Anderson. Recognition of an endothelial determinant for CD18-dependent human neutrophil adherence and transendothelial migration. J. Clin. Invest. 82: 1746-1756, 1988.
20. Walder, C. E., S. P. Green, W. C. Darbonne, J. Mathias, J. Rae, M. C. Dinauer, J. T. Curnutte, and G. R. Thomas. Ischemic stroke injury is reduced in mice lacking a functional NADPH oxidase. Stroke 28: 2252-2258, 1997.