메뉴 건너뛰기




Volumn 64, Issue 1, 1999, Pages 95-103

Chronic, low-level exposure to the cholinesterase inhibitor DFP. I. Time course of neurochemical changes in the rat pontomesencephalic tegmentum

Author keywords

Cholinesterase assay; Chronic low level exposure; DFP; Irreversible cholinesterase inhibitor; Plasma; Pontomesencephalic tegmentum; Quantitative 3H QNB autoradiography; Quantitative cholinesterase histochemistry; Rat; Striatum

Indexed keywords

CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DYFLOS;

EID: 0032885116     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(99)00069-6     Document Type: Article
Times cited : (1)

References (46)
  • 1
    • 0026287448 scopus 로고
    • Lack of desensitization of muscarinic receptor-mediated second messager signals in rat brain upon acute and chronic inhibition of acetylcholinesterase
    • Abdallah E.A.M., El-Fakahany E.E. Lack of desensitization of muscarinic receptor-mediated second messager signals in rat brain upon acute and chronic inhibition of acetylcholinesterase. J. Biochem. Toxicol. 6:1991;261-268.
    • (1991) J. Biochem. Toxicol. , vol.6 , pp. 261-268
    • Abdallah, E.A.M.1    El-Fakahany, E.E.2
  • 2
    • 0030821747 scopus 로고    scopus 로고
    • Location and quantification of muscarinic receptor subtypes in rat pons: Implications for REM sleep generation
    • Baghdoyan H.A. Location and quantification of muscarinic receptor subtypes in rat pons. Implications for REM sleep generation Am. J. Physiol. 273:1997;R896-R904.
    • (1997) Am. J. Physiol. , vol.273
    • Baghdoyan, H.A.1
  • 3
    • 0026024329 scopus 로고
    • Behavioral and neurochemical changes in rats dosed repeatedly with diisopropylfluorophosphate
    • Bushnell P.J., Padilla S.S., Ward T., Pope C.N., Olszyk V.B. Behavioral and neurochemical changes in rats dosed repeatedly with diisopropylfluorophosphate. J. Pharmacol. Exp. Ther. 256:1991;741-750.
    • (1991) J. Pharmacol. Exp. Ther. , vol.256 , pp. 741-750
    • Bushnell, P.J.1    Padilla, S.S.2    Ward, T.3    Pope, C.N.4    Olszyk, V.B.5
  • 4
    • 0027736810 scopus 로고
    • Differential modulation of organophosphate-sensitive muscarinic receptors in rat brain by parathion and chlorpyrifos
    • Chaudhuri J., Chakraborti T.K., Chanda S., Pope C.N. Differential modulation of organophosphate-sensitive muscarinic receptors in rat brain by parathion and chlorpyrifos. J. Biochem. Toxicol. 8:1993;207-216.
    • (1993) J. Biochem. Toxicol. , vol.8 , pp. 207-216
    • Chaudhuri, J.1    Chakraborti, T.K.2    Chanda, S.3    Pope, C.N.4
  • 5
    • 0028944159 scopus 로고
    • Slow accumulation of acetylcholinesterase in rat brain during enzyme inhibition by repeated dosing with chlorpyrifos
    • Chiappa S., Padilla S., Koenigsberger C., Moser V., Brimijoin S. Slow accumulation of acetylcholinesterase in rat brain during enzyme inhibition by repeated dosing with chlorpyrifos. Biochem. Pharmacol. 49:1995;955-963.
    • (1995) Biochem. Pharmacol. , vol.49 , pp. 955-963
    • Chiappa, S.1    Padilla, S.2    Koenigsberger, C.3    Moser, V.4    Brimijoin, S.5
  • 6
    • 0015278616 scopus 로고
    • Tolerance to low acetylcholinesterase levels: Modification of behavior without acute behavioral change
    • Chippendale T.J., Zawolkow G.A., Russell R.W., Overstreet D.H. Tolerance to low acetylcholinesterase levels. Modification of behavior without acute behavioral change Psychopharmacologia. 26:1972;127-139.
    • (1972) Psychopharmacologia , vol.26 , pp. 127-139
    • Chippendale, T.J.1    Zawolkow, G.A.2    Russell, R.W.3    Overstreet, D.H.4
  • 7
    • 0021358253 scopus 로고
    • Topographical distribution of down-regulated muscarinic receptors in rat brains after repeated exposure to diisopropyl phosphorofluoridate
    • Churchill L., Pazdernik T.L., Samson F., Nelson S.R. Topographical distribution of down-regulated muscarinic receptors in rat brains after repeated exposure to diisopropyl phosphorofluoridate. Neuroscience. 11:1984;463-472.
    • (1984) Neuroscience , vol.11 , pp. 463-472
    • Churchill, L.1    Pazdernik, T.L.2    Samson, F.3    Nelson, S.R.4
  • 8
    • 0018908944 scopus 로고
    • 3H]quinuclidinyl benzilate binding in the striatum of rats following chronic cholinesterase inhibition with diisopropylfluorophosphate
    • 3H]quinuclidinyl benzilate binding in the striatum of rats following chronic cholinesterase inhibition with diisopropylfluorophosphate. Mol. Pharmacol. 17:1980;24-30.
    • (1980) Mol. Pharmacol. , vol.17 , pp. 24-30
    • Ehlert, F.J.1    Kokka, N.2    Fairhurst, A.S.3
  • 10
    • 0026482968 scopus 로고
    • Modulation of M1 and M2 muscarinic receptor subtypes following repeated organophosphate exposure in rats
    • Fitzgerald B.B., Costa L.G. Modulation of M1 and M2 muscarinic receptor subtypes following repeated organophosphate exposure in rats. Toxicol. Appl. Pharmacol. 117:1992;122-125.
    • (1992) Toxicol. Appl. Pharmacol. , vol.117 , pp. 122-125
    • Fitzgerald, B.B.1    Costa, L.G.2
  • 11
    • 77957175907 scopus 로고
    • Modulation of muscarinic receptors and acetylcholinesterase activity in lymphocytes and brain areas following repeated organophosphate exposure in rats
    • Fitzgerald B.B., Costa L.G. Modulation of muscarinic receptors and acetylcholinesterase activity in lymphocytes and brain areas following repeated organophosphate exposure in rats. Fundam. Appl. Toxicol. 20:1993;210-216.
    • (1993) Fundam. Appl. Toxicol. , vol.20 , pp. 210-216
    • Fitzgerald, B.B.1    Costa, L.G.2
  • 12
    • 0018782565 scopus 로고
    • Administration of an organophosphate causes a decrease in muscarinic receptor levels in rat brain
    • Gazit H., Silman I., Dudai Y. Administration of an organophosphate causes a decrease in muscarinic receptor levels in rat brain. Brain Res. 174:1979;351-356.
    • (1979) Brain Res. , vol.174 , pp. 351-356
    • Gazit, H.1    Silman, I.2    Dudai, Y.3
  • 13
    • 0025604621 scopus 로고
    • Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropylfluorophosphate
    • Gearhart J.M., Jepson G.W., Clewell H.J., Andersen M.E., Conolly R.B. Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropylfluorophosphate. Toxicol. Appl. Pharmacol. 196:1990;295-310.
    • (1990) Toxicol. Appl. Pharmacol. , vol.196 , pp. 295-310
    • Gearhart, J.M.1    Jepson, G.W.2    Clewell, H.J.3    Andersen, M.E.4    Conolly, R.B.5
  • 14
    • 0013879376 scopus 로고
    • The effect of acute and chronic treatment with diisopropyl fluorophosphate on cholinesterase activities on some tissues of the rat
    • Glow P.H., Rose S., Richardson A. The effect of acute and chronic treatment with diisopropyl fluorophosphate on cholinesterase activities on some tissues of the rat. Aust. J. Exp. Biol. Med. Sci. 44:1966;73-86.
    • (1966) Aust. J. Exp. Biol. Med. Sci. , vol.44 , pp. 73-86
    • Glow, P.H.1    Rose, S.2    Richardson, A.3
  • 15
    • 0030271985 scopus 로고    scopus 로고
    • Quantitative, video-based histochemistry to measure regional effects of anticholinesterase pesticides in rat brain
    • Hammond P.I., Jelacic T., Padilla S., Brimijoin S. Quantitative, video-based histochemistry to measure regional effects of anticholinesterase pesticides in rat brain. Anal. Biochem. 241:1996;82-92.
    • (1996) Anal. Biochem. , vol.241 , pp. 82-92
    • Hammond, P.I.1    Jelacic, T.2    Padilla, S.3    Brimijoin, S.4
  • 16
    • 0025940154 scopus 로고
    • Differential sensitivity of CNS regions to acetylcholinesterase inhibition following chronic low-dose soman treatment in the rat
    • Howerton T.C., Murphy M.R., Miller S.A., Hartgraves S.L. Differential sensitivity of CNS regions to acetylcholinesterase inhibition following chronic low-dose soman treatment in the rat. Psychopharmacology (Berlin). 105:1991;400-406.
    • (1991) Psychopharmacology (Berlin) , vol.105 , pp. 400-406
    • Howerton, T.C.1    Murphy, M.R.2    Miller, S.A.3    Hartgraves, S.L.4
  • 17
    • 78651012385 scopus 로고
    • A histochemical method for localizing cholinesterase activity
    • Koelle G.B., Friedenwald J.S. A histochemical method for localizing cholinesterase activity. Proc. Soc. Exp. Biol. 70:1949;617-622.
    • (1949) Proc. Soc. Exp. Biol. , vol.70 , pp. 617-622
    • Koelle, G.B.1    Friedenwald, J.S.2
  • 18
    • 0017118234 scopus 로고
    • Changes of acetylcholinesterase activity in three major brain areas and related changes in behaviour following acute treatment with diisopropyl fluorophosphate
    • Kozar M.D., Overstreet D.H., Chippendale T.C., Russell R.W. Changes of acetylcholinesterase activity in three major brain areas and related changes in behaviour following acute treatment with diisopropyl fluorophosphate. Neuropharmacology. 15:1976;291-298.
    • (1976) Neuropharmacology , vol.15 , pp. 291-298
    • Kozar, M.D.1    Overstreet, D.H.2    Chippendale, T.C.3    Russell, R.W.4
  • 19
    • 0020634082 scopus 로고
    • Histological and histochemical changes in the central nervous system of the rat poisoned by an irreversible anticholinesterase organophosphorous compound
    • Lemercier G., Carpentier P., Sentenac-Roumanou H., Morelis P. Histological and histochemical changes in the central nervous system of the rat poisoned by an irreversible anticholinesterase organophosphorous compound. Acta Neuropathol. 61:1983;123-129.
    • (1983) Acta Neuropathol. , vol.61 , pp. 123-129
    • Lemercier, G.1    Carpentier, P.2    Sentenac-Roumanou, H.3    Morelis, P.4
  • 20
    • 0022485211 scopus 로고
    • Correlation of muscarinic receptor density and acetylcholinesterase activity in repeated DFP-treated rats after the termination of DFP administration
    • Lim D.K., Hoskins B., Ho I.K. Correlation of muscarinic receptor density and acetylcholinesterase activity in repeated DFP-treated rats after the termination of DFP administration. Eur. J. Pharmacol. 123:1986;223-228.
    • (1986) Eur. J. Pharmacol. , vol.123 , pp. 223-228
    • Lim, D.K.1    Hoskins, B.2    Ho, I.K.3
  • 21
    • 0024723561 scopus 로고
    • Effects of diisopropylfluorophosphate on brain acetylcholinesterase, butyrylcholinesterase, and neurotoxic esterase in rats
    • Lim D.K., Hoskins B., Ho I.K. Effects of diisopropylfluorophosphate on brain acetylcholinesterase, butyrylcholinesterase, and neurotoxic esterase in rats. Biomed. Environ. Sci. 2:1989;295-304.
    • (1989) Biomed. Environ. Sci. , vol.2 , pp. 295-304
    • Lim, D.K.1    Hoskins, B.2    Ho, I.K.3
  • 22
    • 77957175603 scopus 로고
    • Characterization of disulfoton-induced behavioral and neurochemical effects following repeated exposure
    • Llorens J., Crofton K.M., Tilson H.A., Ali S.F., Mundy W.R. Characterization of disulfoton-induced behavioral and neurochemical effects following repeated exposure. Fundam. Appl. Toxicol. 20:1993;163-169.
    • (1993) Fundam. Appl. Toxicol. , vol.20 , pp. 163-169
    • Llorens, J.1    Crofton, K.M.2    Tilson, H.A.3    Ali, S.F.4    Mundy, W.R.5
  • 23
    • 0021895514 scopus 로고
    • 3H]diisopropylfluorophosphate in mice
    • 3H]diisopropylfluorophosphate in mice. Toxicol. Appl. Pharmacol. 77:1985;275-284.
    • (1985) Toxicol. Appl. Pharmacol. , vol.77 , pp. 275-284
    • Martin, B.R.1
  • 26
    • 0019838277 scopus 로고
    • Regional differences in brain-soluble acetylcholinesterase and its molecular forms after acute poisoning by isoflurophate in rats
    • Meneguz A., Bisso G.M., Michalek H. Regional differences in brain-soluble acetylcholinesterase and its molecular forms after acute poisoning by isoflurophate in rats. Clin. Toxicol. 18:1981;1443-1451.
    • (1981) Clin. Toxicol. , vol.18 , pp. 1443-1451
    • Meneguz, A.1    Bisso, G.M.2    Michalek, H.3
  • 27
    • 0020326775 scopus 로고
    • Mechanisms of recovery of brain acetylcholinesterase in rats during chronic intoxication with isofluorophate
    • Michalek H., Meneguz A., Bisso G.M. Mechanisms of recovery of brain acetylcholinesterase in rats during chronic intoxication with isofluorophate. Arch. Toxicol. Suppl. 5:1982;116-119.
    • (1982) Arch. Toxicol. Suppl. , vol.5 , pp. 116-119
    • Michalek, H.1    Meneguz, A.2    Bisso, G.M.3
  • 28
    • 0027238479 scopus 로고
    • Effect of repeated organophosphate administration on carbachol-stimulated phosphoinositide hydrolysis in the rat brain
    • Mundy W.R., Ward T.R., Dulchinos V.F., Tilson H.A. Effect of repeated organophosphate administration on carbachol-stimulated phosphoinositide hydrolysis in the rat brain. Pharmacol. Biochem. Behav. 45:1993;309-314.
    • (1993) Pharmacol. Biochem. Behav. , vol.45 , pp. 309-314
    • Mundy, W.R.1    Ward, T.R.2    Dulchinos, V.F.3    Tilson, H.A.4
  • 29
    • 0018360070 scopus 로고
    • Sex differences following pharmacological manipulation of the cholinergic system by DFP and pilocarpine
    • Overstreet D.H., Russell R.W., Helps S.C., Runge P., Prescott A.M. Sex differences following pharmacological manipulation of the cholinergic system by DFP and pilocarpine. Psychopharmacology (Berlin). 61:1979;49-58.
    • (1979) Psychopharmacology (Berlin) , vol.61 , pp. 49-58
    • Overstreet, D.H.1    Russell, R.W.2    Helps, S.C.3    Runge, P.4    Prescott, A.M.5
  • 30
    • 0028100624 scopus 로고
    • Studies on the correlation between blood cholinesterase inhibition and "target tissue" inhibition in pesticide-treated rats
    • Padilla S., Wilson V.Z., Bushnell P.J. Studies on the correlation between blood cholinesterase inhibition and "target tissue" inhibition in pesticide-treated rats. Toxicology. 92:1994;11-25.
    • (1994) Toxicology , vol.92 , pp. 11-25
    • Padilla, S.1    Wilson, V.Z.2    Bushnell, P.J.3
  • 32
    • 0025321641 scopus 로고
    • Impaired recovery of brain muscarinic receptor sites following an adaptive down-regulation induced by repeated administration of diisopropyl fluorophosphate in aged rats
    • Pintor A., Fortuna S., De Angelis S., Michalek H. Impaired recovery of brain muscarinic receptor sites following an adaptive down-regulation induced by repeated administration of diisopropyl fluorophosphate in aged rats. Life Sci. 46:1990;1027-1036.
    • (1990) Life Sci. , vol.46 , pp. 1027-1036
    • Pintor, A.1    Fortuna, S.2    De Angelis, S.3    Michalek, H.4
  • 33
    • 0031017665 scopus 로고    scopus 로고
    • Chronic, low-level exposure to diisopropylfluorophosphate causes protracted impairment of spatial navigation learning
    • Prendergast M.A., Terry A.V., Buccafusco J.J. Chronic, low-level exposure to diisopropylfluorophosphate causes protracted impairment of spatial navigation learning. Psychopharmacology (Berlin). 129:1997;183-191.
    • (1997) Psychopharmacology (Berlin) , vol.129 , pp. 183-191
    • Prendergast, M.A.1    Terry, A.V.2    Buccafusco, J.J.3
  • 35
    • 0023137824 scopus 로고
    • Mechanisms underlying sensitivity to organophosphorus anticholinesterase compounds
    • Russell R.W., Overstreet D.H. Mechanisms underlying sensitivity to organophosphorus anticholinesterase compounds. Prog. Neurobiol. 28:1987;97-129.
    • (1987) Prog. Neurobiol. , vol.28 , pp. 97-129
    • Russell, R.W.1    Overstreet, D.H.2
  • 36
    • 26944476338 scopus 로고    scopus 로고
    • Neurotoxicity and pattern of acetylcholinesterase inhibition in the brain regions of rat by bromophos and ethylbromophos
    • Santhoshkumar P., Karanth S., Shivanandappa T. Neurotoxicity and pattern of acetylcholinesterase inhibition in the brain regions of rat by bromophos and ethylbromophos. Fundam. Appl. Toxicol. 32:1996;23-30.
    • (1996) Fundam. Appl. Toxicol. , vol.32 , pp. 23-30
    • Santhoshkumar, P.1    Karanth, S.2    Shivanandappa, T.3
  • 37
    • 0019832028 scopus 로고
    • Reduced muscarinic receptor binding in tissues of rats tolerant to the insecticide disulfoton
    • Schwab B.W., Hand H., Costa L.G., Murphy S.D. Reduced muscarinic receptor binding in tissues of rats tolerant to the insecticide disulfoton. Neurotoxicology. 2:1981;635-647.
    • (1981) Neurotoxicology , vol.2 , pp. 635-647
    • Schwab, B.W.1    Hand, H.2    Costa, L.G.3    Murphy, S.D.4
  • 38
    • 0002496330 scopus 로고    scopus 로고
    • The mesopontine cholinergic system: A dual role in REM sleep and wakefulness
    • R. Lydic, & H.A. Baghdoyan. Boca Raton, FL: CRC Press
    • Semba K. The mesopontine cholinergic system. A dual role in REM sleep and wakefulness Lydic R., Baghdoyan H.A. Handbook of behavioural state control. Cellular and molecular mechanisms:1999;161-180 CRC Press, Boca Raton, FL.
    • (1999) Handbook of Behavioural State Control: Cellular and Molecular Mechanisms , pp. 161-180
    • Semba, K.1
  • 39
    • 0021192673 scopus 로고
    • An assessment of comparative acute toxicity of diisopropyl-fluorophosphate, tabun, sarin, and soman in relation to cholinergic and GABAergic enzyme activities in rats
    • Sivam S.P., Hoskins B., Ho I.K. An assessment of comparative acute toxicity of diisopropyl-fluorophosphate, tabun, sarin, and soman in relation to cholinergic and GABAergic enzyme activities in rats. Fundam. Appl. Toxicol. 4:1984;531-538.
    • (1984) Fundam. Appl. Toxicol. , vol.4 , pp. 531-538
    • Sivam, S.P.1    Hoskins, B.2    Ho, I.K.3
  • 40
    • 0020622154 scopus 로고
    • Effect of acute and chronic cholinesterase inhibition with diisopropylfluorophosphate on muscarinic, dopamine, and GABA receptors of the rat striatum
    • Sivam S.P., Norris J.C., Lim D.K., Hoskins B., Ho I.K. Effect of acute and chronic cholinesterase inhibition with diisopropylfluorophosphate on muscarinic, dopamine, and GABA receptors of the rat striatum. J. Neurochem. 40:1983;1414-1422.
    • (1983) J. Neurochem. , vol.40 , pp. 1414-1422
    • Sivam, S.P.1    Norris, J.C.2    Lim, D.K.3    Hoskins, B.4    Ho, I.K.5
  • 42
    • 0021339187 scopus 로고
    • Changes in the levels and forms of rat plasma cholinesterases during chronic diisopropylphosphorofluoridate intoxication
    • Traina M.E., Serpietri L.A. Changes in the levels and forms of rat plasma cholinesterases during chronic diisopropylphosphorofluoridate intoxication. Biochem. Pharmacol. 33:1984;645-653.
    • (1984) Biochem. Pharmacol. , vol.33 , pp. 645-653
    • Traina, M.E.1    Serpietri, L.A.2
  • 43
    • 0026582490 scopus 로고
    • Species differences in diisopropylfluorophosphate-induced decreases in the number of brain nicotinic receptors
    • Van de Kamp J.L., Collins A.C. Species differences in diisopropylfluorophosphate-induced decreases in the number of brain nicotinic receptors. Pharmacol. Biochem. Behav. 42:1992;131-141.
    • (1992) Pharmacol. Biochem. Behav. , vol.42 , pp. 131-141
    • Van De Kamp, J.L.1    Collins, A.C.2
  • 44
    • 0024839913 scopus 로고
    • On the development of behavioral tolerance to organophosphates I: Behavioral and biochemical aspects
    • Van Dongen C.J., Wolthuis O.L. On the development of behavioral tolerance to organophosphates I. Behavioral and biochemical aspects Pharmacol. Biochem. Behav. 34:1989;473-481.
    • (1989) Pharmacol. Biochem. Behav. , vol.34 , pp. 473-481
    • Van Dongen, C.J.1    Wolthuis, O.L.2
  • 45
    • 0020559062 scopus 로고
    • Correlation between cholinesterase inhibition and reduction in muscarinic receptors and choline uptake by repeated diisopropylfluorophosphate administration: Antagonism by physostigmine and atropine
    • Yamada S., Isogai M., Okudaira H., Hayashi E. Correlation between cholinesterase inhibition and reduction in muscarinic receptors and choline uptake by repeated diisopropylfluorophosphate administration. antagonism by physostigmine and atropine J. Pharmacol. Exp. Ther. 226:1983;519-525.
    • (1983) J. Pharmacol. Exp. Ther. , vol.226 , pp. 519-525
    • Yamada, S.1    Isogai, M.2    Okudaira, H.3    Hayashi, E.4
  • 46
    • 0020582131 scopus 로고
    • Regional adaptation of muscarinic receptors and choline uptake in brain following repeated administration of diisopropylfluorophosphate and atropine
    • Yamada S., Isogai M., Okudaira H., Hayashi E. Regional adaptation of muscarinic receptors and choline uptake in brain following repeated administration of diisopropylfluorophosphate and atropine. Brain Res. 268:1983;315-320.
    • (1983) Brain Res. , vol.268 , pp. 315-320
    • Yamada, S.1    Isogai, M.2    Okudaira, H.3    Hayashi, E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.