Enantioseparation of thalidomide and its hydroxylated metabolites using capillary electrophoresis with various cyclodextrins and their combinations as chiral buffer additives

Electrophoresis

Volumn 20, Issue 12, 1999, Pages 2425-2431

  Meyring, Michael ^a   Chankvetadze, Bezhan ^a   Blaschke, Gottfried ^a,b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b TBILISI STATE UNIVERSITY   (Georgia)

Author keywords

Chiral drug and metabolites; Cyclodextrins; Enantioseparation in CE; Metabolites of thalidomide; Thalidomide

Indexed keywords

BIOMOLECULES; CAPILLARITY; CAPILLARY ELECTROPHORESIS; CYCLODEXTRINS; FUSED SILICA; HYDROXYLATION;

CHARGED CYCLODEXTRINS; CHIRAL DRUGS; CHIRAL METABOLITES; ENANTIOSEPARATION IN CAPILLARY ELECTROPHORESIS; ENANTIOSEPARATIONS; HYDROXYLATED METABOLITES; METABOLITE OF THALIDOMIDE; OH -; SIMULTANEOUS ENANTIOSEPARATIONS; THALIDOMIDE;

METABOLITES;

5 HYDROXYTHALIDOMIDE; 5' HYDROXYTHALIDOMIDE; BUFFER; CYCLODEXTRIN; DRUG METABOLITE; THALIDOMIDE; THALIDOMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD; CAPILLARY ELECTROPHORESIS; CHIRALITY; DIASTEREOISOMER; DRUG DISCRIMINATION; DRUG STRUCTURE; ENANTIOMER; HUMAN; HUMAN TISSUE; HYDROXYLATION; LIVER MICROSOME; METABOLITE; PHASE SEPARATION; STEREOSPECIFICITY;

EID: 0032884217     PISSN: 01730835     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1522-2683(19990801)20:12<2425::AID-ELPS2425>3.0.CO;2-W     Document Type: Article

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