Platelet protein kinase C alpha levels in drug-free and lithium-treated subjects with bipolar disorder

Neuropsychobiology

Volumn 40, Issue 2, 1999, Pages 63-66

  Young, L Trevor ^a,b   Wang, Jun Feng ^a   Woods, Caroline M ^a   Robb, Janine C ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b NONE   (Canada)

Author keywords

Bipolar disorder; Depression; Lithium; Platelet; Protein kinase C ; Second messenger

Indexed keywords

LITHIUM; PROTEIN KINASE C;

ADULT; ARTICLE; CLINICAL ARTICLE; FEMALE; HUMAN; IMMUNOBLOTTING; MALE; MANIC DEPRESSIVE PSYCHOSIS; PRIORITY JOURNAL; THROMBOCYTE;

ADULT; ANTIMANIC AGENTS; BIPOLAR DISORDER; BLOOD PLATELETS; BLOTTING, WESTERN; CASE-CONTROL STUDIES; CELL MEMBRANE; CYTOSOL; FEMALE; HUMANS; ISOENZYMES; LITHIUM; MALE; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA;

EID: 0032882728     PISSN: 0302282X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000026598     Document Type: Article

References (21)

1. Friedman E, Wang HY, Levinson D, Connell TA, Singh H: Altered platelet protein kinase C activity in bipolar affective disorder, manic episode. Biol Psychiatry 1993;33:520-525.
2. Godfrey PP, McClue SJ, White AM, Wood AJ, Grahame-Smith DG: Subacute and chronic in vivo lithium treatment inhibits agonist-and sodium fluoride-stimulated inositol phosphate production in rat cortex. J Neurochem 1989; 52:498-506.
3. Brown AS, Mallinger AG, Renbaum LC: Elevated platelet membrane phosphatidylinositol-4,5-bisphosphate in bipolar mania. Am J Psychiatry 1993;150:1252-1254.
4. Ebstein RP, Lerer B, Bennett ER, Shapira B, Kindler S, Shemesh Z, Gerstenhaber N: Lithium modulation of second messenger signal amplification in man: Inhibition of phosphatidylinositol-specific phospholipase C and adenylate cyclase activity. Psychiatry Res 1987;24: 45-52.
5. Hallcher LM, Sherman WR: The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain. J Biol Chem 1980;255:10896-10901.
6. Wang J-F, Li PP, Wash JJ, Young LT: Signal transduction abnormalities in bipolar disorder; in Young LT, Joffe RT (eds): Bipolar Disorder: Biological Models and Their Clinical Applications, New York, Dekker, 1997, pp 41-79.
7. Jensen JB, Mork A: Altered protein phosphorylation in the rat brain following chronic lithium and carbamazepine treatments. Eur Neuropsychopharmacol 1997;7:173-179.
8. Manji HK, Bersudsky Y, Chen G, Belmaker RH, Potter WZ: Modulation of protein kinase C isozymes and substrates by lithium: The role of myo-inositol. Neuropsychopharmacology 1996;15:370-381.
9. Anderson SMP, Godfrey PP, Grahame-Smith DG: The effects of phorbol esters and lithium on 5-HT release in rat hippocampal slices. Br J Pharmacol 1988;93(suppl):96P.
10. Wang H-Y, Friedman E: Lithium inhibition of protein kinase C activation-induced serotonin release. Psychopharmacology 1989;99:213-218.
11. Birtan JA, Gusovsky F, Manji HK, Potter W: Effects of chronic lithium treatment on signal transduction mechanisms in HL60 cells. Biol Psychiatry 1989;25:46A.
12. Lenox RH, Watson DG: Targets for lithium action in the brain: Protein kinase C substrates and muscarinic receptor regulation. Clin Neuropharmacol 1991;15(suppl):612A-613A.
13. Li PP, Sibony D, Green M, Warsh JJ: Lithium modulation of the phosphoinositide signalling system in rat cortex: Selective effects on phorbol ester binding. J Neurochem 1993;61:1722-1730.
14. Manji HK, Etcheberrigaray R, Chen G, Olds JL: Lithium decreases membrane-associated protein kinase C in hippocampus: Selectivity for the a isozyme. J Neurochem 1993;61:2303-2310.
15. Chen G, Manji HK, Hgawver DB, Wright CB, Potter WZ: Chronic sodium valproate selectively decreases protein kinase C α and ε in vitro. J Neurochem 1994;63:2361-2364.
16. Lenox RH, Watson DG, Patel J, Ellis J: Chronic lithium administration alters a prominent PKC substrate in rat hippocampus. Brain Res 1992;570:333-340.
17. Wang H-Y, Friedman E: Enhanced protein kinase C activity and translocation in bipolar affective disorder brains. Biol Psychiatry 1996; 40:568-575.
18. Young LT, Woods CM, Robb JC, Patelis-Siotis I, Asghari V, Sokolov ST: Platelet endogenous adenosine 5′-diphosphate ribosylation in drug-free and lithium-treated subjects with bipolar disorder. Biol Psychiatry 1997;42:413-415.
19. Jope RS, Song L, Li PP, Young LT, Kish SJ, Pacheco MA, Warsh JJ: The phosphoinositide signal transduction system is impaired in bipolar affective disorder brain. J Neurochem 1996; 66:2402-2409.
20. Dubovosky SL, Christiano J, Daniell LC, Franks RD, Murphy J, Adler L, Baker N, Harris RA: Increased platelet intracellular calcium concentration in patients with bipolar affective disorders. Arch Gen Psychiatry 1989;46:632-638.
21. Dubovsky SL, Murphy J, Thomas M, Rademacher J: Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients. Am J Psychiatry 1992;149: 118-120.