Modulation of protein kinase C isozymes and substrates by lithium: The role of myo-inositol

Neuropsychopharmacology

Volumn 15, Issue 4, 1996, Pages 370-381

  Manji, Husseini K ^a   Bersudsky, Yuly ^b   Chen, Guang ^a   Belmaker, Robert H ^b   Potter, William Z ^c  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MENTAL HEALTH CENTER   (Israel)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

G proteins; Lithium; Manic depressive; Myo inositol; Protein kinase C

Indexed keywords

INOSITOL; ISOENZYME; LITHIUM; PROTEIN KINASE C;

AFFECTIVE NEUROSIS; ANIMAL EXPERIMENT; ARTICLE; MALE; NEUROTRANSMISSION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

EID: 0030272375     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0893-133X(95)00243-7     Document Type: Article

References (64)

1. Agranoff BW, Bradley RM, Brady RO (1958): The enzymatic synthesis of inositol phosphatide. J Biol Chem 233:1077-1083
2. Allison JH, Stewart MA (1971): Reduced brain inositol in lithium-treated rats. Nature New Biol 233:267-268
3. Atack JR, Cook SM, Watt AP, Ragan CI (1993): In vitro and in vivo inhibition of inositol monophosphatase by the biphosphonate L-690,330. J Neurochem 60:652-658
4. Atack JR, Prior AM, Fletcher SR, Quirk K, McKernan R, Ragan CI (1994): Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase inhibitor L-690,330, on phosphatidylinositol cycle markers. J Pharmacol Exp Ther 270: 70-76
5. Avissar S, Schreiber G, Danon A, Belmaker RH (1988): Lithium inhibits adrenergic and cholinergic increases in GTP binding in rat cortex. Nature 331:440-442
6. Batty IH, Downes CP (1994): The inhibition of phosphoinositide synthesis and muscarinic-receptor-mediated phospholipase C activity by Li+ as secondary, selective, consequences of inositol depletion in 1321N1 cells. Biochem J 297:529-537
7. Belmaker RH (1981): Receptors, adenylate cyclase, depression, and lithium. Bio Psychiatry 16:333-350
8. Benjamins JA, Agranoff BW (1969) Distribution and properties of of CDP-diglyceride:inositol transferase from brain. J Neurochem 16:513-527
9. Berridge MJ, Downes CP, Hanley MR (1982): Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands. Biochem J 206:587-595.
10. Berridge MJ, Downes CP, Hanley MR (1989): Neural and developmental actions of lithium: A unifying hypothesis. Cell 59:411-419.
11. Bersudsky Y, Vinnitsky I, Grisaru N, Kofman O, Belmaker RH (1993): Dose-response and time curve of inositol prevention of Li-pilocarpine seizures. Eur Neuropsychopharmacol 3:428-429
12. Borner C, Guadango SN, Fabbro D, Weinstein IB (1992): Expression of four PKC isozymes in rat fibroblasts: distinct subcellular distribution and regulation by calcium and phorbol esters. J Biol Chem 267:12892-12899
13. Bradford MM (1976): A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 223-229
14. Brami BA, Leli U, Hauser G (1991a): Influence of lithium on second messenger accumulation in NG108-15 cells. Biochem Biophys Res Commun 174:606-612
15. Brami BA, Leli U, Hauser G (1991b): Origin of the diacylglycerol produced in excess of inositol phosphates by lithium in NG108-15 cells. J Neurochem 57:(Supp) S9
16. Busa WB, Gimlich RL (1989): Lithium-induced teratogenesis in frog embryos prevented by a polyphosphoinositide cycle intermediate or a diacylglycerol analog. Dev Biol 132:315-324.
17. Casebolt TL, Jope RS (1989): Long-term lithium treatment selectively reduces receptor-coupled inositol phospholipid hydrolysis in rat brain. Biol Psychiatry 25:329-340
18. Downes CP, Stone MA (1986): Lithium-induced reduction in intracellular inositol supply in cholinergically stimulated parotid gland. Biochem J 234:199-204
19. Drummond AH, Raeburn CA (1984): The interaction of lithium with thyrotropin releasing hormone-stimulated lipid metabolism in GH3 pituitary tumor cells. Biochem J 244:129-136.
20. Ebstein R, Belmaker R, Grunhaus L, Rimon R (1976): Lithium inhibition of adrenaline-stimulated adenylate cyclase in humans. Nature 259:411-413
21. Eichberg J, Abe S, Berti-Mattera LN, Day NS, Lowery JM, Zhu X, Peterson RG (1993): Inositol and phospholipid metabolism in diabetic nerve. Diab Med 10(suppl 2):16S-20S
22. Erusalimsky JD, Brooks SF, Herget T, Morris C, Rozengurt E (1991): Molecular cloning and characterization of the acidic 80-kDa protein kinase C substrate from rat brain. J Biol Chem 266:7073-7080
23. Fisher SK, Heacock AM, Agranoff BW (1992): Inositol lipids and signal transduction in the nervous system: An update. J Neurochem 58:18-38
24. Ghalayani A, Eichberg J (1985): Purification of phosphatidylinositol synthetase from rat brain by CDP-diacylglycerol affinity chromatography and properties of the purified enzyme. J Neurochem 44:175-182.
25. Godfrey PP, McClue SJ, White AM, Wood AJ, Grahame SD (1989): Subacute and chronic in vivo lithium treatment inhibits agonist-and sodium fluoride-stimulated inositol phosphate production in rat cortex. J Neurochem 52:498-506
26. Goodwin FK, Jamison KR (1990): Manic-Depressive Illness. New York, Oxford University Press
27. Greenwood AF, and Jope RS (1994): Brain G-protein proteolysis by calpain: Enhancement by lithium. Brain Res 636:320-326
28. Hallcher LM, Sherman WR (1980): The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain. J Biol Chem 255:10896-10901
29. Houslay MD (1991): "Crosstalk": A pivotal role for protein kinase C in modulating relationships between signal transduction pathways. Eur J Biochem 195:9-27
30. Hsiao JK, Manji HK, Chen GA, Bitran JA, Risby ED, Potter WZ (1992): Lithium administration modulates platelet Gi in humans. Life Sci 50:227-233
31. Imai A, Gershengorn MC (1987): Independent phosphatidylinositol synthesis in pituitary plasma membrane and endoplasmic reticulum. Nature 325:726-728
32. Isakov N, McMahon P, Altman A (1990): Selective post-translational down-regulation of protein kinase C isozymes in leukemic T cells chronically treated with phorbol ester. J Biol Chem 265:2091-2097
33. Janowsky DS, El-Yousef MK, Davis JM, Serkerke HJ (1972): A cholinergic-adrenergic hypothesis of mania and depression. Lancet 2:632-635
34. Jope RS, Williams MB (1994): Lithium and brain signal transduction systems. Biochem Pharmacol 47:429-434
35. Kendall DA, Nahorski SR (1987): Acute chronic lithium treatments influence agonist-and depolarization-stimulated inositol phospholipid hydrolysis in rat cerebral cortex. J Pharmacol Exp Ther 241:1023-1027
36. Kennedy ED, Chaliss RJ, Nahorski SR (1989): Lithium reduces the accumulation of inositol polyphosphate second messengers following cholinergic stimulation of cerebral cortex slices. J Neurochem 53:1652-1655
37. Kennedy ED, Challiss RAJ, Ragan CI (1990): Reduced inositol polyphosphate accumulation and inositol supply induced by lithium in stimulated cerebral cortex slices. Biochem J 267:781-786
38. Kim J, Rushovich EH, Thomas TP, Agranoff BW, Greene DA (1991): Diminished specific activity of cytosolic Protein kinase C in sciatic nerve of streptozocin-induced diabetic rats and its correction by myo-inositol. Diabetes 40:1545-1554
39. Kishimoto A, Mikawa K, Hashimoto K, Yasuda I, Tanaka S, Tominaga M, Kuroda T, Nishizuka Y (1989): Limited proteolysis of protein kinase C subspecies by calcium-dependent neutral protease (calpain). J Biol Chem 264:4088-4092
40. Kofman O, Belmaker RH (1993): Biochemical, behavioral, and clinical studies of the role of inositol in lithium treatment and depression. Biol Psychiatry 34:839-852
41. Kofman O, Belmaker RH, Grisaru N (1991): Myo-inositol attenuates two specific behavioral effects of acute lithium in rats. Psychopharmacol Bull 27:185-190
42. Kofman O, Sherman WR, Katz V, Belmaker RH (1993): Restoration of brain myo-inositol levels in rats increases latency to lithium-pilocarpine seizures. Psychopharmacology 110:229-234
43. Laemmli UD (1970): Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-684
44. Lenox RH, Manji HK (1995): Lithium. In CB Nemeroff and AF Schatzberg (eds), American Psychiatric Press Textbook of Psychopharmacology. Washington, DC, American Psychiatric Press, pp 303-350
45. Lenox RH, Watson DG, Patel J, Ellis J (1992): Chronic lithium administration alters a prominent PKC substrate in rat hippocampus. Brain Res 570:333-340.
46. Levine J, Barak Y, Gonsalves M, Szor H, Elizur A, Kofman O, Belmaker RH (1995): A double-blind controlled study of inositol treatment of depression. Am J Psychiatry 152: 792-794
47. Linder D, Gschwendt M, Marks F (1992): Phorbol ester-induced down-regulation of the 80-kDa myristoylated alanine-rich C-kinase substrate-related protein in Swiss 3T3 fibroblasts. Inhibition by staurosporine. J Biol Chem 267:24-26
48. Manji HK (1992): G proteins: Implications for psychiatry. Am J Psychiatry 149:746-760.
49. Manji HK, Lenox RH (1994): Long-term action of lithium: A role for transcriptional and posttranscriptional factors regulated by protein kinase C. Synapse 16:11-28
50. Manji HK, Potter WZ, Lenox RH (1995): Signal transduction pathways: Molecular targets for lithium's actions. Arch Gen Psychiatry 52(7):531-543
51. Manji HK, Etcheberrigaray R, Chen G, Olds JL (1993): Lithium decreases membrane-associated protein kinase C in hippocampus: Selectivity for the α isozyme. J Neurochem 61:2303-2310
52. Mork A, Geisler A, Hollund P (1992): Effects of lithium on second messenger systems in the brain. Pharmacol Toxicol 71(S1):4-17
53. Pontzer NJ, Crews FT (1990): Desensitization of muscarinic stimulated hippocampal cell firing is related to phosphoinositide hydrolysis and inhibited by lithium. J Pharmacol Exp Ther 253:921-929
54. Rana RS, Hokin LE (1990): Role of Phosphoinositides in Transmembrane Signaling. Physiol Rev 70:115-164
55. Sherman WR, Munsell LY, Gish BG, Honchar MP (1985) Effects of systemically administered lithium on phosphoinositide metabolism in rat brain, kidney and testis. J Neurochem 45:2639-2646
56. Stubbs EB, Argranoff BW (1993): Lithium enhances muscarinic receptor-stimulated CDP-diacylglycerol formation in inositol-depleted SK-N-SH neuroblastoma cells. J Neurochem 60:1292-1299
57. Sun GY, Navidi M, Yoa FG (1992): Lithium effects on inositol phospholipids and inositoil phosphates: Evaluation of an in vivo model for assessing polyphosphoinositide turnover in brain. J Neurochem 58:290-297
58. Tricklebank MD, Singh L, Jackson A (1991): Evidence that a proconvulsant action of lithium is mediated by inhibition of myo-inositol phosphatase in mouse brain. Brain Res 558:145-148.
59. Ui M (1990): Pertussis Toxin as a valuable probe for G protein involvement in signal transduction. In J Moss and M Vaughn (eds), ADP-Ribosylation Toxins and G Proteins. Washington, DC, American Society for Microbiology
60. Varney MA, Godfrey PP, Drummond AH, Watson SP (1992): Chronic lithium treatment inhibits basal and agonist-stimulated responses in rat cerebral cortex and GH3 pituitary cells. Mol Pharmacol 42:671-678
61. Watson SP, Shipman L, Godfrey PP (1990): Lithium potentiates agonist formation of [3H]CDP-diacylglycerol in human platelets. Eur J Pharmacol 188:273-276
62. Williams MB, Jope RS (1995): Modulation by inositol of cholinergic-and serotonergic-induced seizures in lithium treated rats. Brain Res 685:169-178
63. Young S, Parker PJ, Ullrich A, Stabel S (1987): Down-regulation of Protein kinase C is due to an increased rate of degradation. Biochem J 24:775-779
64. Zhu X, Eichberg J (1990): A myo-inositol pool utilized for phosphatidylinositol synthesis is depleted in sciatic nerve from rats with streptozotocin-induced diabetes. Proc Natl Acad Sci U S A 87(24):9818-9822