Rapid absorption and clinical effectiveness of intragastric mefloquine in the treament of cerebral malaria in African children

Journal of Antimicrobial Chemotherapy

Volumn 44, Issue 4, 1999, Pages 573-576

  Di Perri, Giovanni ^b   Olliaro, Piero ^a   Ward, Stephen ^c   Allegranzi, Benedetta ^c   Bonora, Stefano ^c   Concia, Ercole ^c  

^a WORLD HEALTH ORGANIZATION   (Switzerland)

^b UNIVERSITY OF VERONA   (Italy)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; MEFLOQUINE;

ARTICLE; BRAIN MALARIA; BURUNDI; CASE REPORT; COMA; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG EFFICACY; HUMAN; INFANT; INTRAGASTRIC DRUG ADMINISTRATION; NASOGASTRIC TUBE; PRESCHOOL CHILD;

ABSORPTION; ANTIMALARIALS; CHILD, PRESCHOOL; HUMANS; INFANT; MALARIA, CEREBRAL; MEFLOQUINE;

EID: 0032882317     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/44.4.573     Document Type: Article

References (10)

1. Warrell, D. A., Molyneux, M. E. & Beals, P. F. (1990). Severe and complicated malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 84, Suppl. 2, 1-65.
2. Pradines, B., Rogier, C., Fusai, T., Tall, A., Trape, J. F. & Doury, J. C. (1998). In vitro activity of artemether against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial drugs. American Journal of Tropical Medicine and Hygiene 58, 354-7.
3. Abdi, Y. A., Gustafsson, L. L., Ericsson, O. & Hellgren, U. (1995). Mefloquine. In Handbook of Drugs for Tropical Parasitic Infections, 2nd edn, (Abdi, Y. A., Gustafsson, L. L., Ericsson, O. & Hellgren, U., Eds), pp. 82-88, Taylor and Francis, London.
4. Molyneux, M. E., Taylor, T. E., Wirima, J. J. & Borgstein, A. (1989). Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. Quarterly Journal of Medicine 71, 441-59.
5. Riviere, J. H., Back, D. J., Breckenridge, A. M. & Howells, R. E. (1985). The pharmacokinetics of mefloquine in man: lack of effect of mefloquine on antipyrine metabolism. British Journal of Clinical Pharmacology 20, 469-74.
6. Black, R. H., Canfield, C. J., Clyde, D. F., Peters, W. & Wernsdorfer, W. H. (1986). Drug resistance in malaria. In Chemotherapy of Malaria, (Bruce-Chwatt, L. J., Ed.), pp. 102-18, World Health Organization, Geneva.
7. White, N. J. (1997). Assessment of the pharmacodynamic properties of antimalarial drugs in vivo. Antimicrobials Agents and Chemotherapy 41, 1413-22.
8. Di Perri, G., Di Perri, I. G., Monteiro, G. B., Bonora, S., Hennig,C., Cassatella, M. A. et al. (1995). Pentoxifylline as supportive agent in the treatment of cerebral malaria in children. Journal of Infectious Diseases 171, 1317-22.
9. Chanthavanich, P., Looareesuwan, S., White, N. J., Warrell, D. A., Warrell, M. J., Di Giovanni, J. H. et al. (1985). Intragastric mefloquine is absorbed rapidly in patients with cerebral malaria. American Journal of Tropical Medicine and Hygiene 34, 1028-36.
10. Karbwang, J. & White, N. J. (1990). Clinical pharmacokinetics of mefloquine. Clinical Pharmacokinetics 19, 264-79.