5-AZA-2'-Deoxycytidine-Induced Dysmorphogenesis in the Rat

Teratogenesis Carcinogenesis and Mutagenesis

Volumn 19, Issue 5, 1999, Pages 329-338

  Branch, Stacy ^a   Chernoff, N ^b   Brownie, C ^a   Magnus Francis, B ^c  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Axial skeletal malformations; Cytidine analog; Interspecies differences; Limb malformations; Teratogenicity

Indexed keywords

5 AZA 2' DEOXYCYTIDINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLEFT PALATE; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; FETUS; GENE EXPRESSION; LIMB MALFORMATION; NONHUMAN; PHOCOMELIA; PRIORITY JOURNAL; RAT; SKELETON MALFORMATION; SPECIES DIFFERENCE; TERATOGENESIS; VERTEBRA MALFORMATION;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; AZACITIDINE; BONE AND BONES; ECTROMELIA; FEMALE; FETAL WEIGHT; HINDLIMB; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; SKULL; SPECIES SPECIFICITY;

ANIMALIA;

EID: 0032880648     PISSN: 02703211     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-6866(1999)19:5<329::AID-TCM3>3.0.CO;2-S     Document Type: Article

References (19)

1. Li E, Bestor TH, Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 1992;69:915-926.
2. Cote S. Momparler RL. Activation of the retinoic acid receptor beta gene by 5-aza-2′-deoxycytidine in human DLD-1 colon carcinoma cells. Anticancer Drug 1997;8:56-61.
3. Soprano DR, Tairis N, Gyda M 3rd, Harnish DC, Jiang H, Soprano KJ, Kochhar DM. induction of RAR-beta 2 gene expression in embryos and RAR-beta-2 transactivation by the synthetic retinoid Ro 13-6307 correlates with its high teratogenic potency. Toxicol Appl Pharmacol 1993;122:159-163.
4. rd, Harnish DC, Chandraratna RA, Soprano KJ, Kochhar DM, Soprano DR. Teratogenesis by retinoic acid analogs positively correlates with elevation of retinoic acid receptor-beta 2 mRNA levels in treated embryos. Teratology 1994;50:38-43.
5. Cash DE, Bock CB, Schughart K, Linney E, Underhill TM. Retinoic acid receptor alpha function in vertebrate limb skeletogenesis: a modulator of chondrogenesis. J Cell Biol 1997;136:445-457.
6. Rogers JM, Francis BM, Sulik KK, Alles AJ, Massaro EJ, Zucker RM, Elstein KH, Rosen MB, Chernoff N. Cell death and cell cycle perturbation in the developmental toxicity of the demethylating agent, 5-aza-2′-deoxycytidine. Teratology 1994;50:332-339.
7. Branch S, Francis FM, Brownie CF, Chernoff N. Teratogenic effects of the demethylating agent 5-aza-2′-deoxycytidine in the Swiss Webster mouse. Toxicology 1996;112:37-43.
8. Branch S, Francis BM, Rosen MB, Brownie CF, Held GA, Chernoff N. Differentially expressed genes associated with 5-aza-2′-deoxycytidine-induced hindlimb defects in the Swiss Webster mouse. J Biochem Molec Toxicol 1998;12:135-141.
9. Schmahl W, Torok P, Kriegel H. Embryotoxicity of 5-azacytidine in mice. Phase- and dose-specificity studies. Arch Toxicol 1984;55:143-147.
10. Rosen MB, House HS, Francis BM, Chernoff N. Teratogenicity of 5-azacytidine in the Sprague-Dawley rat. J Toxicol Environ Health 1990;29:201-210.
11. SAS. SAS User's Guide. Cary, NC: SAS Institute.
12. Taylor P. A practical teratology. New York: Academic Press; 1986.
13. Shepard TH. Catalog of teratogenic agents, 8th ed. Baltimore: Johns Hopkins University Press; 1994.
14. Heindel JJ, Price CJ, Schwetz BA. The developmental toxicity of boric acid in mice, rats, and rabbits. Environ Health Perspect 1994;102:5-11.
15. Cherrington JW, Rosen MB, Branch S, Dauterman WC, Chernoff N. Axial skeletal effects of boric acid administered on single days of gestation in the CD-1 mouse. Teratology 1995;51:181.
16. Kessel M. Respecification of vertebral identities by retinoic acid. Development 1992;115:487-501.
17. Cherrington JW. Effects of boric acid on the developing vertebral column and ribs in the CD-1 mouse in utero. PhD Thesis, North Carolina State University; 1998.
18. Peterson RL, Papenbrock T, Davda MM, Awgulewitsch A. The murine Hoxc cluster contains five neighboring AbdB-related Hox genes that show unique spatially coordinated expression in posterior embryonic subregions. Mech Dev 1994;47:253-260.
19. Logan M, Tabin CJ. Role of Pitx1 upstream of Tbx4 in specification of hindlimb identity. Science 1999;283:1736-1739.