The synthetic potential of enone Mannich bases for the synthesis of novel 5-benzoyl-1,4,5,6-tetrahydropyrimidines

Synthesis

Volumn , Issue 9, 1999, Pages 1637-1641

  Girreser, Ulrich ^a   Heber, Dieter ^a   Schütt, Martin ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

1 arylprop 2 en 1 ones; 5 benzoyl 1,4,5,6 tetrahydropyrimidines; Amidines; Deamination; Mannich salts

Indexed keywords

ANTHELMINTIC AGENT; ANTIDEPRESSANT AGENT; BENZYL DERIVATIVE; MANNICH BASE; OXANTEL; OXYPHENCYCLIMINE; PYRANTEL; PYRIMIDINE DERIVATIVE; TETRAHYDROPYRAN DERIVATIVE;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; DEAMINATION; DRUG ACTIVITY; DRUG SYNTHESIS; REACTION ANALYSIS; SPECTROSCOPY;

EID: 0032878741     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1999-3577     Document Type: Article

References (15)

1. McFarland, J. W.; Conover, L. H.; Howes, Jr, H. L.; Lynch, J. E.; Chisholm, D. R.; Austin, W. C.; Cornwell, R. L.; Danilewicz, J. C.; Courtney, W.; Morgan, D. H. J. Med. Chem. 1969, 12, 1066.
2. McFarland, J. W.; Howes, Jr, H. L. J. Med. Chem. 1972, 15, 365.
3. Faust, J. A.; Mori, A.; Sahyun, M. J. Amer. Chem. Soc. 1959, 81, 2214.
4. Negwer, M. Organic-chemical Drugs and Their Synonyms, Vol. II; Akademie-Verlag: Berlin 1994; p 1743.
5. Weinhardt, K.; Wallach, M. B.; Marx, M. J. Med. Chem. 1985, 28, 694.
6. Messer, Jr., W. S.; Dunbar, P. G.; Rho, T.; Periyasamy, S.; Ngur, D.; Ellerbrock, B. R.; Bohnett, M.; Ryan, K.; Durant, G. J.; Hoss, W. Bioorg. Med. Chem. 1992, 2, 781.
7. Dunbar, P. G.; Durant, G. J.; Fang, Z.; Rho, T.; Abuh, Y. F.; El-Assadi, A. A.; Ngur, D.; Periyasamy, S.; Hoss, W.; Messer, Jr., W. S. J. Med. Chem. 1993, 36, 842.
8. Dunbar, P. G.; Durant, G. J.; Rho, T.; Ojo, B.; Huzl, J. J., III; Smith, D. A.; El-Assadi, A. A.; Sbeih, S.; Ngur, D. O.; Periyasamy, S.; Hoss, W.; Messer, Jr., W. S. J. Med. Chem. 1994, 37, 2774.
9. Messer, Jr., W. S.; Abuh, Y. F.; Liu, Y.; Periyasamy, S.; Ngur, D. O.; Edgar, M. A. N.; El-Assadi, A. A.; Sbeih, S.; Dunbar, P. G.; Roknich, S.; Rho, T.; Fang, Z.; Ojo, B; Zhang, H.; Huzl, J. J., III; Nagy, P. I. J. Med. Chem. 1997, 40, 1230.
10. Girreser, U.; Heber, D.; Schütt, M. Synthesis 1998, 715.
11. Girreser, U.; Heber, D.; Schütt, M. Synlett 1998, 263.
12. Girreser, U.; Heber, D.; Schütt, M. J. Heterocycl. Chem. 1998, 35, 1455.
13. Cromwell, N. H.; Soriano, D. S.; Doomes, E. J. Org. Chem. 1980, 45, 4983.
14. Clement, B.; Kämpchen, D. Chem. Ber. 1986, 119, 1101.
15. Böhm, H.-J.; Klebe, G.; Kubinyi, H. Wirkstoffdesign, Der Weg zum Arzneimittel, Spektrum Akademischer Verlag: Heidelberg, 1996; p 159.