Modulation of cell growth and transformation by doxycycline-regulated FGF-2 expression in NIH-3T3 cells

Journal of Cellular Physiology

Volumn 181, Issue 2, 1999, Pages 273-284

  Gualandris, Anna ^a   Arese, Marco ^a   Shen, Bin ^a   Rifkin, Daniel B ^a,b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; FIBROBLAST GROWTH FACTOR 2;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN 3T3; CELL TRANSFORMATION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

EID: 0032876727     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1097-4652(199911)181:2<273::aid-jcp9>3.0.co;2-%23     Document Type: Article

References (39)

1. Arese M, Chen Y, Florkiewicz R, Gualandris A, Shen B, Rifkin DB. 1999. Nuclear activities of FGF-2: potentiation of low serum growth mediated by natural or chimeric nuclear localization signals. Mol Biol Cell 10:1429-1444.
2. Basilico C, Moscatelli D. 1992. The FGF family of growth factors and oncogenes. Adv Cancer Res 59:115-165.
3. Bieshke ET, Wheeler JC, Tower J. 1998. Doxycycline-induced transgene expression during Drosophila development and aging. Mol Gen Genet 258:571-579.
4. Bikfalvi A, Klein S, Pintucci G, Quarto N, Mignatti P, Rifkin DB. 1995. Differential modulation of cell phenotype by different molecular weight forms of basic fibroblast growth factor: possible intracellular signaling by the high molecular weight forms. J Cell Biol 129:233-243.
5. Chen J, Kelz MB, Zeng G, Sakai N, Steffen C, Shockett PE, Picciotto MR, Duman RS, and Nestler EJ. 1998. Transgenic animals with inducible, targeted gene expression in brain. Mol Pharmacol 54: 495-503.
6. Coltrini D, Gualandris A, Nelli EE, Parolini S, Molinari-Tosatti MP, Quarto N, Ziehe M, Giavazzi R, Presta M. 1995. Growth advantage and vascularization induced by basic fibroblast growth factor overexpression in endometrial HEC-1B cells: an export-dependent mechanism of action. Cancer Res 55:4729-4738.
7. Dono R, James D, Zeller R. 1998. A GR-motif functions in nuclear accumulation of the large FGF-2 isoforms and interferes with mitogenic signaling. Oncogene 16:2151-2158.
8. Florkiewicz RZ, Sommer A. 1989. Human basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codons. Proc Natl Acad Sci USA 86:3978-3981.
9. Furth PA, St Onge L, Boger H, Gruss P, Gossen M, Kistner A, Bujard H, Hennighausen L. 1994. Temporal control of gene expression in transgenic mice by tetracycline-responsive promoter. Proc Natl Acad Sci USA 91:9302-9306.
10. Gossen M, Freundlib S, Bender G, Muller G, Hillen W, Bujard E. 1995. Transcriptional activation by tetracyclines in mammalian cells. Science 268:1766-1769.
11. 2-terminal extension of high molecular weight forms of basic fibroblast growth factor (bFGF) is not essential for the binding of bFGF to nuclear chromatin in transfected NIH 3T3 cells. Growth Factors 8:49-60.
12. Gualandris A, Urbinati C, Rusnati M, Ziehe M, Presta M. 1994. Interaction of high molecular weight basic fibroblast growth factor (bFGF) with endothelium: biological activity and intracellular fate of human recombinant Mr 24,000 bFGF. J Cell Physiol 161:149-159.
13. Gualandris A, Rusnati M, Belleri M, Molinari-Tosatti MP, Bonardi F, Albini A, Ziehe M, Presta M. 1996a. Angiogenic phenotype induced by basic fibroblast growth factor transfection in brain microvascular endothelial cells: an in vitro autocrine model of angiogenesis in brain tumors. Int J Oncol 8:567-573.
14. Gualandris A, Rusnati M, Belleri M, Nelli EE, Bastaki M, Molinari Tosatti MP, Parolini S, Albini A, Morbidelli L, Ziche M, Corallini A, Possati L, Vacca A, Ribatti D, Presta M. 1996b. Basic fibroblast growth factor overexpression in endothelial cells: an autocrine mechanism for angiogenesis and angioproliferative diseases. Cell Growth Differ 7:147-160.
15. Howe JR, Skryabin BV, Balcher SM, Zerillo CA, Schmauss C. 1995. The responsiveness of a tetracycline-sensitive expression system differs in different cell lines. J Biol Chem 270:14168-14174.
16. Kistner A, Gossen M, Zimmermann F, Jerecic J, Ullmer C, Lubbert H, Bujard H. 1996. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. Proc Natl Acad Sci USA 93:10933-10938.
17. Kueng W, Silve E, Eppendberger V. 1989. Quantification of cells cultured on 96-well plates. Anal Biochem 182:16-19.
18. Maciag T, Mehlman T, Friesel R, Schreiber AB. 1984. Heparin binds endothelial cell growth factor, the principal endothelial cell mitogen in bovine brain. Science 225:932-935.
19. Mohammadi SA, Alvarez-Vallina L, Ashworth LJ, Hawkins RE. 1997. Delay in resumption of the activity of tetracycline-regulatable promoter following removal of tetracycline analogues. Gene Ther 4:769-773.
20. Montesano R, Vassalli JD, Baird A, Guillemin R, Orci L. 1986. Basic fibroblast growth factor induces angiogenesis in vitro. Proc Natl Acad Sci USA 83:7297-7301.
21. Moscatelli D. 1988. Metabolism of receptor-bound and matrix-bound basic fibroblast growth factor by bovine capillary endothelial cells. J Cell Biol 107:753-759.
22. Moscatelli D, Joseph-Silverstein J, Manejias R, Rifkin DB. 1987. Mr 25,000 heparin-binding protein from guinea pig brain is a high molecular weight form of basic fibroblast growth factor. Proc Natl Acad Sci USA 84:5778-5782.
23. Park HJ, Raj Bhandary VR. 1998. Tetracycline-regulated suppression of amber codons in mammalian cells. Mol Cell Biol 18:4418-4425.
24. Pintucci G, Quarto N, Rifkin DB. 1996. Methylation of high molecular weight fibroblast growth factor-2 determines post-translational increases in molecular weight and affects its intracellular distribution. Mol Biol Cell 7:1249-1259.
25. Prats H, Kaghad M, Prats C, Klagsbrun M, Lelias JM, Liazun P, Chalon P, Tauber JP, Amalric F, Smith JA, Caput D. 1989. High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons. Proc Natl Acad Sci USA 86:1836-1840.
26. Presta M, Moscatelli D, Joseph-Silverstein J, Rifkin DB. 1986. Purification from a human hepatoma cell line of a basic fibroblast growth factor-like molecule that stimulates capillary endothelial cell plasminogen activator production, DNA synthesis and migration. Mol Cell Biol 6:4060-4066.
27. Quarto N, Talarico D, Sommer A, Florkiewicz R, Basilico C, Rifkin DB. 1989. Transformation by basic fibroblast growth factor requires high levels of expression: comparison with transformation by hst/ K-FGF Oncogene Res 5:101-109.
28. 2-terminal extension of high molecular weight bFGF is a nuclear targeting signal. J Cell Physiol 147:311-318.
29. Quarto N, Talarico D, Florkiewicz R, Rifkin DB. 1991b. Selective expression of high molecular weight basic fibroblast growth factor confers a unique phenotype to NIH 3T3 cells. Cell Regul 2:699-708.
30. Ray P, Tang W, Wang P, Homer R, Kuh C, Flavell RA, Elias JA. 1997. Regulated overexpression of interleukin 11 in the lung. J Clin Inv 100:2501-2511.
31. Renko M, Quarto N, Morimoto T, Rifkin DB. 1990. Nuclear and cytoplasmic localization of different basic fibroblast growth factor species. J Cell Physiol 144:108-114.
32. Saksela O, Rifkin DB. 1990. Release of basic fibroblast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator-mediated proteolytic activity. J Cell Biol 110:767-775.
33. Seghezzi G, Patel S, Ren CJ, Gualandris A, Pintucci G, Robbins EE, Shapiro RL, Galloway AG, Rifkin DB, Mignatti P. 1998. Fibroblast growth factor 2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: an autocrine mechanism contributing to angiogenesis. J Cell Biol 141: 1659-1673.
34. Sola F, Gualandris A, Belleri M, Giuliani R, Coltrini D, Bastaki M, Molinari Tosatti MP, Bonardi F, Vecchi A, Fioretti F, Giavazzi R, Ciomei M, Grandi M, Mantovani A, Presta M. 1997. Endothelial cells overexpressing basic fibroblast growth factor (FGF-2) induce vascular tumors in immunodeficient mice. Angiogenesis 1:102-116.
35. Sommer A, Brewer MT, Thompson RC, Moscatelli D, Presta M, Rifkin DB. 1987. A form of human basic fibroblast growth factor with an extended amino terminus. Biochem Biophys Res Commun 144:543-550.
36. St. Onge L, Furth PA, Gruss P. 1996. Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter. Nucleic Acids Res 24:3875-3877.
37. Thomas KA, Rios-Candelore M, Fitzpatrick S. 1984. Purification and characterization of acidic fibroblast growth factor from bovine brain. Proc Natl Acad Sci USA 81:357-361.
38. Watsuji T, Okamoto Y, Emi N, Katsuoka Y, Hagiwara M. 1997. Controlled gene expression with a reverse tetracycline regulated retroviral vector (RTRV) system. Biochem Biophys Res Commun 234:769-773.
39. Wu SY, Chiang CM. 1996. Establishment of stable cell lines expressing potentially toxic proteins by tetracycline-regulated and epitopetagging methods. Biotechniques 21:718-722.