A new helicoid-type sequential oligopeptide carrier (SOC(n)) for developing potent antigens and immunogens

Vaccine

Volumn 18, Issue 3-4, 1999, Pages 302-310

  Sakarellos Daitsiotis, Maria ^a   Tsikaris, Vassilios ^a   Sakarellos, Constantinos ^a   Vlachoyiannopoulos, Panayiotis G ^b   Tzioufas, Athanassios G ^b   Moutsopoulos, Haralampos M ^b  

^a Sect Organ Chem Biochem U   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

1H NMR spectroscopy; Autoimmune diseases; Carriers of immunogenic peptides; Immune response; Immunoassays; Peptide carriers; Peptide conformation; Synthesis of carriers; Vaccines

Indexed keywords

DRUG CARRIER; EPITOPE; SYNTHETIC PEPTIDE;

ANIMAL EXPERIMENT; AUTOIMMUNITY; CONFERENCE PAPER; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOASSAY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CONFORMATION; RABBIT;

AMINO ACID SEQUENCE; ANTIGENS; DRUG CARRIERS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; VACCINES, SYNTHETIC;

EID: 0032876567     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(99)00201-7     Document Type: Conference Paper

References (21)

1. Muller S. Use of synthetic peptides for the analysis of B-cell epitopes in autoantigens. Zouali M. Autoimmunity: Experimental Aspects. NATO ASI Series. Vol. H 80:1994;75-89 Springer-Verlag, Berlin, Heidelberg.
2. Elkon K.B. Use of synthetic peptides in the detection and quantification of autoantibodies. Mol. Biol. Rep. 16:1992;207-212.
3. Kaumaya P.T.P., Kobs-Conrad S., Hoon Seo Y., Lee H., VanBuskirk A.M., Feng N., Sheridan J.F., Steven V. Peptide vaccines incorporating a 'promiscous' T-cell epitope bypass certain haplotype restricted immune responses and provide broad spectrum immunogenicity. J. Mol. Recogn. 6:1993;81-94.
4. Arnon R., Van Regenmortel M.H.V. Structural basis of antigenic specificity and design of new vaccines. FASEB J. 6:1992;3265-3274.
5. Posnett D.N., McGrath H., Tam J.P. A novel method for producing anti-peptide antibodies: production of site-specific antibodies to the T-cell antigen receptor β-chain. J. Biol. Chem. 263:1988;1719-1725.
6. Metzger J., Wiesmuller K.H., Schaude R., Bessler W.G., Jung G. Synthesis of novel immunologically active tripalmitoyl-S-glycerylcysteinyl lipopeptides as useful intermediates for immunogen preparations. Int. J. Peptide Protein Res. 37:1991;46-57.
7. Tuchscherere G., Domer B., Sila U., Kamber B., Mutter M. The TASP concept: mimetics of peptide ligands, protein surfaces and folding units. Tetrahedron. 49:1993;3559-3575.
8. Tsikaris V., Sakarellos C., Cung M.T., Marraud M., Sakarellos-Daitsiotis M. Concept and design of a new class of sequential oligopeptide carriers (SOC) for covalent attachment of multiple antigenic peptides. Biopolymers. 38:1996;291-293.
9. n) for producing potent antigens and effective immunogens. Hadjiliadis N. Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment. NATO ASI Series 2 Environment. Vol. 26:1997;605-614 Kluwer Academic Publishers.
10. n) for multiple anchoring of antigenic peptides-application to the acetylcholine receptor (AChR) main immunogenic region. Int. J. Biol. Macromol. 19:1996;195-205.
11. n) in the design of potent Leishmania gp63 immunogenic peptides. Peptide Res. 9:1996;240-247.
12. Tsikaris V., Vlachoyiannopoulos P.G., Panou-Pomonis E., Marraud M., Sakarellos C., Moutsopoulos H.M., Sakarellos-Daitsiotis M. Immunoreactivity and conformation of the P-P-G-M-R-P-P repetitive epitope of the Sm autoantigen. Int. J. Peptide Protein Res. 48:1996;319-327.
13. Tzioufas A.G., Yiannaki E., Sakarellos-Daitsiotis M., Routsias J.G., Sakarellos C., Moutsopoulos H.M. Fine specificity of autoantibodies to La/SSB: epitope mapping and characterization. Clin. Exp. Immunol. 108:1997;191-198.
14. Yiannaki E.E., Tzioufas A.G., Bachmann M., Hantoumi J., Tsikaris V., Sakarellos-Daitsiotis M., Sakarellos C., Moutsopoulos H.M. The value of synthetic linear epitope analogues of La/SSB for the detection of autoantibodies to La/SSB; specificity and comparison of methods. Clin Exp. Immunol. 112:1998;152-158.
15. Sakarellos C., Tsikaris V., Panou-Pomonis E., Alexopoulos C., Sakarellos-Daitsiotis M., Petrovas C., Vlachoyiannopoulos P.G., Moutsopoulos H.M. The PPGMRPP repetitive epitope of the Sm autoantigen: antigenic specificity induced by conformational changes. Application of the sequential oligopeptide carriers (SOCs). Lett. Peptide Sci. (LIPS). 4:1997;447-454.
16. Petrovas C., Vlachoyiannopoulos P.G., Tzioufas A.G., Alexopoulos C., Tsikaris V., Sakarellos-Daitsiotis M., Sakarellos C., Moutsopoulos H.M. A major Sm epitope, anchored to sequential oligopeptide carriers is a suitable antigenic substrate to detect anti-Sm antibodies. J. Immunol. Methods. 220:1998;59-68.
17. Sakarellos C., Alexopoulos Ch., Tsikaris V., Sakarellos-Daitsiotis M., Petrovas C., Vlachoyiannopoulos P.G., Tzioufas A.G., Moutsopoulos H.M. Development of an experimental systemic lupus erythematosus (SLE) like disease after immunization with the Sm epitope PPGMRPP anchored to an artificial Carrier. XVIII European workshop for rheumatology research. Clin. Exp. Rheumatol. 16:1998;208.
18. Yiannaki E.E., Tzioufas A.G., Manoussakis M.N., Sakarellos-Daitsiotis M., Sakarellos C., Moutsopoulos H.M. Immunizations of synthetic epitope analogues of La/SSB autoantigen elicits intramolecular but not intermolecular spreading. XVII European workshop for rheumatology research. Clin. Exp. Rheumatol. 16:1998;208.
19. Rose N.R., McKay I.R. The immune response in autoimmunity and autoimmune disease. Rose N.R., McKay. The autoimmune diseases II. 1992;1-26 Academic Press.
20. Pecanha L., Snapper C., Finkelman F., Monod J.J. Dextran-conjugated anti-Ig antibodies as a model for T-cell type 2 antigen-mediated stimulation of Ig secretion in vitro: lymphokine dependence. J. Immunol. 146:1991;833-839.
21. Parker D.C. T-cell dependent B-cell activation. Ann Rev. Immunol. 11:1993;331-340.