Bupivacaine-loaded comatrix formed by albumin microspheres included in a poly(lactide-co-glycolide) film: In vivo biocompatibility and drug release studies

Biomaterials

Volumn 20, Issue 20, 1999, Pages 1919-1924

  Blanco, M D ^a   Bernardo, M V ^a   Gomez C ^a   Muniz E ^a   Teijon J M ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Albumin microspheres; Biocompatibility; Bupivacaine; Comatrix; Histological studies; Pharmacokinetic; Poly(lactide co glycolide) film

Indexed keywords

BIOCOMPATIBILITY; BIODEGRADATION; DRUG PRODUCTS; PHARMACOKINETICS; PLASTIC FILMS; POLYESTERS;

MICROSPHERES; POLYLACTIDE CO-GLYCOLIDE;

IMPLANTS (SURGICAL);

BOVINE SERUM ALBUMIN; BUPIVACAINE; COPOLYMER; MICROSPHERE; POLYGLACTIN;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BIOCOMPATIBILITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG RELEASE; HISTOLOGY; MALE; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; BIOCOMPATIBLE MATERIALS; BUPIVACAINE; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG IMPLANTS; LACTIC ACID; MALE; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; POLYGLYCOLIC ACID; POLYMERS; RATS; RATS, WISTAR; SERUM ALBUMIN, BOVINE; TIME FACTORS;

EID: 0032876399     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0142-9612(99)00092-7     Document Type: Article

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