Synthesis and biological evaluation of 2-methoxy- and 2-Methylthio-6-[(2'-alkylamino)ethyl]-4(3H)-pyrimidinones with anti-rubella virus activity

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 9, 1999, Pages 1925-1931

  Botta, Maurizio ^a   Occhionero, Francesca ^b   Nicoletti, Rosario ^b   Mastromarino, Paola ^b   Conti, Cinzia ^b   Magrini, Maurizio ^b   Saladino, Raffaele ^c  

^a UNIVERSITY OF SIENA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF TUSCIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; PYRIMIDINE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG SCREENING; DRUG SYNTHESIS; NONHUMAN; RUBELLA; RUBELLA VIRUS; SINDBIS VIRUS; VESICULAR STOMATITIS VIRUS;

ANIMALS; ANTIVIRAL AGENTS; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PLAQUE ASSAY; PYRIMIDINONES; RUBELLA VIRUS; SPECTRUM ANALYSIS; VERO CELLS;

EID: 0032874389     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00111-X     Document Type: Article

References (16)

1. Botta M., Saladino R., Occhionero F., Nicoletti R. Trends Org. Chem. 5:1995;57 and references cited therein.
2. Kim D.K., Gam J., Kim Y.W., Lim J., Kim H.T., Kim K.H. J. Med. Chem. 40:1997;2363.
3. Pontikis R., Benhida R., Aubertin A.M., Grierson D.S., Monneret C. J. Med. Chem. 40:1997;1845.
4. Baba M., De Clercq E., Tanaka H., Ubasawa M., Takashima H., Sekiya K., Nitta I., Umezu K., Walker R.T., Mori S., Ito M., Shigeta S., Miyasaka T. Mol. Pharmacol. 39:1991;805.
5. Tanaka H., Takashima H., Ubasawa M., Sekiya K., Nitta I., Baba M., Shigeta S., Walker R.T., De Clercq E., Miyasaka T. J. Med. Chem. 35:1992;4713.
6. Balzarini J., Karlsson A., De Clercq E. Mol. Pharmacol. 44:1993;694.
7. Baba M., Tanaka H., Miyasaka T., Yuasa S., Ubasawa M., Walker R.T., De Clercq E. Nucleosides Nucleotides. 14:1995;575.
8. Mai A., Artico M., Sbardella G., Quartarone S., Massa S., Loi A.G., De Montis A., Scintu F., Putzolu M., La Colla P. J. Med. Chem. 40:1997;1447.
9. Das P., Spears C.P., Shahinian A.H., Dasgupta S.K., Kundu N.G. Bioorg. Med. Chem. Lett. 6:1996;2477.
10. Botta M., Saladino R., Gambacorta A., Nicoletti R. Tetrahedron: Asymmetry. 1:1990;441.
11. Saladino R., Danti M.C., Mincione E., Crestini C., Palamara A.T., Savini P., Marini S., Botta M. Bioorg. Med. Chem. Lett. 8:1998;1833.
12. Botta M., Occhionero F., Saladino R., Crestini C., Nicoletti R. Tetrahedron Lett. 38:1997;8249.
13. Botta M., Saladino R., Lamba D., Nicoletti R. Tetrahedron. 49:1993;6053.
14. Terly K.F. Advances in Virus Res. 44:1994;69.
15. Hayakawa Y., Hirose M., Noyori R. J. Org. Chem. 58:1993;5551.
16. 2), 6.58 (1H, s, CH), 7.33 (2H, d, J=9.0 Hz, CH), 7.90 (2H, d, J=9.0 Hz, CH).