Antigen-induced bronchial hyperresponsiveness in the rabbit is not dependent on M2-receptor dysfunction

Pulmonary Pharmacology and Therapeutics

Volumn 12, Issue 4, 1999, Pages 245-255

  Patel, H J ^a   Douglas, G J ^b   Herd, C M ^c   Spina, D ^c   Giembycz, M A ^a   Barnes, P J ^a   Belvisi, M G ^d   Page, C P ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b NORTHWICK PARK INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d SANOFI   (France)

Author keywords

Acetylcholine release; Airway responsiveness; Cholinergic nerves; Rabbit airways; Sensitization

Indexed keywords

ACETYLCHOLINE; ALLERGEN; ANTIGEN; MUSCARINIC M2 RECEPTOR; OXOTREMORINE; SEROTONIN;

ACETYLCHOLINE RELEASE; AIRWAY; ALTERNARIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS HYPERREACTIVITY; CHOLINERGIC NERVE; CONTROLLED STUDY; ELECTRIC FIELD; FEMALE; IMMUNIZATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; RABBIT; SENSITIZATION; SMOOTH MUSCLE; TRACHEA;

EID: 0032873125     PISSN: 10945539     EISSN: None     Source Type: Journal    
DOI: 10.1006/pupt.1999.0204     Document Type: Article

References (55)

1. Sterk P J, Bel E H. Bronchial hyperresponsiveness: the need for a distinction between hypersensitivity and excessive airway narrowing. Eur Respir J. 2:1989;267-274.
2. Pinckard R N, Halonen M, Meng A L. Preferential expression of anti-bovine serum albumin IgE homocytotropic antibody synthesis and analphylactic sensitivity in the neonatal rabbit. J Allergy Clin Immunol. 49:1972;301-310.
3. Shampain M P, Behrens B L, Larsen G L, Henson P M. An animal model of late pulmonary responses to Alternaria challenge. Am Rev Respir Dis. 126:1982;493-498.
4. Larsen G L, Wilson M C, Clark A R F, Behrens B L. The inflammatory reaction in the airway in an animal model of late asthmatic response. Fed Proc. 46:1987;105-112.
5. Coyle A J, Page C P, Atkinson L, Sjoerdsma K, Touvay C, Metzger W J. Modification of allergen-induced airway obstruction and airway hyperresponsiveness in an allergic rabbit model by the selective platelet-activating factor antagonist, BN 52021. J Allergy Clin Immunol. 84:1989;960-967.
6. Coyle A J, Page C P, Atkinson L, Flanagan R, Metzger W J. The requirement for platelets in allergen-induced late asthmatic airway obstruction. Eosinophil infiltration and heightened airway responsiveness in allergic rabbits. Am Rev Respir Dis. 142:1990;587-593.
7. Marsh W R, Irvin C G, Murphy K R, Behrens B L, Larsen G L. Increases in airway reactivity to histamine and inflammatory cells in bronchoalveolar lavage after the late asthmatic response in an animal model. Am Rev Respir Dis. 131:1985;875-879.
8. Murphy K R, Wilson M C, Irvin C G, Glezen L S, Marsh W R, Haslett C. The requirement for polymorphonuclear leukocytes in the last asthmatic response and heightened airway reactivity in an animal model. Am Rev Respir Dis. 134:1986;62-68.
9. Bloom J W, Baumgartener F C, Palmer J D, Halonen M. Airway cholinergic responsiveness in rabbits in relation to antigen sensitization and challenge. Immunopharmacology. 15:1988;157-167.
10. Herd C M, Donigi G D, Shoupe T S, Burroughs D A, Yeadon M, Page C P. Effect of a 5-lipoxygenase inhibitor and leukotriene antagonist (PF 5901) on antigen-induced airway responses in neonatally immunized rabbits. Br J Pharmacol. 112:1994;292-298.
11. Gozzard N, El-Hashim A, Herd C M, Blake S M, Holbrook M, Hughes B, Higgs G, Page C P. Effect of the glucocorticosteroid budesonide and a novel phosphodiesterase type 4 inhibitor CDP840 on antigen-induced airway responses in neonatally immunised rabbits. Br J Pharmacol. 118:1996;1201-1208.
12. Ali S, Mustafa S J, Metzger W J. Adenosine receptor-mediated bronchoconstriction and bronchial hyperresponsiveness in allergic rabbit model. Am J Physiol. 266:1994;L271-L277.
13. El-Hashim A, D'Agostino B, Matera M G, Page C. Characterization of adenosine receptors involved in adenosine-induced bronchoconstriction in allergic rabbits. Br J Pharmacol. 119:1996;1262-1268.
14. Nyce J W, Metzger W J. DNA antisense therapy for asthma in an animal model. Nature. 385:1997;721-725.
15. Riccio M M, Manzini S, Page C P. The effect of neonatal capsaicin on the development of bronchial hyperresponsiveness in allergic rabbits. Eur J Pharmacol. 232:1993;89-97.
16. Herd C M, Gozzard N, Page C P. Capsaicin pre-treatment prevents the development of antigen-induced airway hyperresponsiveness in neonatally immunised rabbits. Eur J Pharmacol. 282:1995;111-119.
17. 2-muscarinic receptors in pulmonary parasympathetic nerves after antigen challenge. J Appl Physiol. 71:1991;2255-2261.
18. 2muscarinic receptor function in antigen challenged guinea-pigs. Br J Pharmacol. 124:1998;267-276.
19. Ten-Berge R E, Krikke M, Teisman A C, Roffel A F, Zaagsma J. Dysfunctional muscarinic M2 autoreceptors in vagally induced bronchoconstriction of conscious guinea pigs after the early allergic reaction. Eur J Pharmacol. 318:1996;131-139.
20. Elbon C L, Jacoby D B, Fryer A D. Pretreatment with an antibody to interleukin-5 prevents loss of pulmonary M2 muscarinic receptor function in antigen-challenged guinea pigs. Am J Respir Cell Mol Biol. 12:1995;320-328.
21. Fryer A D, Jacoby D B. Parainfluenza virus infection damages inhibitory M2 muscarinic receptors on pulmonary parasympathetic nerves in the guinea-pig. Br J Pharmacol. 102:1991;267-271.
22. Fryer A D, Yarkony K A, Jacoby D B. The effect of leukocyte depletion on pulmonary M2 muscarinic receptor function in parainfluenza virus-infected guinea-pigs. Br J Pharmacol. 112:1994;588-594.
23. Larsen G L, Fame T M, Renz H, Loader J E, Graves J, Hill M, Gelfand E W. Increased acetylcholine release in tracheas from allergen-exposed IgE-immune mice. Am J Physiol. 266:1994;L263-L270.
24. Minshall E M, Riccio M M, Herd C M, Douglas G J, Seeds E A, McKenniff M G, Sacaki M, Spina D, Page C P. A novel animal model for investigating persistent airway hyperresponsiveness. J Pharmacol Toxicol Methods. 30:1993;177-188.
25. Flecknall P A. Laboratory Animal Anaesthesia: an Introduction for Research Workers. London: Academic Press. 1987.
26. Lendrum A C. The staining of eosinophil polymorphs and enterochromaffin cells in histological sections. J Biol Chem. 259:1944;5520-5526.
27. Walters E H, O'Byrne P M, Fabbri L M, Graf P D, Holtzman M J, Nadel J A. Control of neurotransmission by prostaglandins in canine trachealis smooth muscle. J Appl Physiol. 57:1984;129-134.
28. Deckers I A, Rampart M, Bult H, Herman A G. Evidence for the involvement of prostaglandins in modulation of acetylcholine release from canine bronchial tissue. Eur J Pharmacol. 167:1989;415-418.
29. Wessler I, Hellwig D, Racke K. Epithelium-derived inhibition of [3H] acetylcholine release from the isolated guinea-pig trachea. Naunyn Schmiedebergs Arch Pharmacol. 342:1990;387-393.
30. Ward J K, Belvisi M G, Fox A J, Miura M, Tadjkarimi S, Yacoub M H, Barnes P J. Modulation of cholinergic neural bronchoconstriction by endogenous nitric oxide and vasoactive intestinal peptide in human airways in vitro. J Clin Invest. 92:1993;736-742.
31. D'Agostino G, Chiari M C, Grana E, Subissi A, Kilbinger H. Muscarinic inhibition of acetylcholine release from a novel in vitro preparation of the guinea-pig trachea. Naunyn Schmiedebergs Arch Pharmacol. 342:1990;141-145.
32. Patel H J, Barnes P J, Takahashi T, Tadjkarimi S, Yacoub M H, Belvisi M G. Evidence for prejunctional muscarinic autoreceptors in human and guinea pig trachea. Am J Respir Crit Care Med. 152:1995;872-878.
33. Tanaka D T, Ando R E, Larsen G L, Irvin C G. Cholinergic mechanisms involved with histamine hyperreactivity in immune rabbit airways challenged with ragweed antigen. Am Rev Respir Dis. 144:1991;70-75.
34. Bloom J W, Baumgartener F C, Palmer J D, Yamamura H I, Halonen M. A muscarinic receptor subtype modulates vagally stimulated bronchial contraction. J Appl Physiol. 65:1988;2144-2150.
35. Eltze M, Galvan M. Involvement of muscarinic M2 and M3, but not of M1 and M4 receptors in vagally stimulated contractions of rabbit bronchus/trachea. Pulm Pharmacol. 7:1994;109-120.
36. Cockcroft D W, Killian D N, Mellon J J, Hargreave F E. Bronchial reactivity to inhaled histamine: a method and clinical survey. Clin Allergy. 7:1977;235-243.
37. Cushley M J, Tattersfield A E, Holgate S T. Inhaled adenosine and guanosine on airway resistance in normal and asthmatic subjects. Br J Clin Pharmacol. 15:1983;161-165.
38. Polosa R, Ng W, Crimi N, Vancheri C, Holgate S, Church M, Mistretta A. Release of mast-cell-derived mediators after endobronchial adenosine challenge in asthma. Am J Respir Crit Care Med. 151:1995;624-629.
39. 1receptors. J Physiol. 508:1998;109-118.
40. Gustafsson L E, Wiklund N P, Cederqvist B. Apparent enhancement of cholinergic transmission in rabbit bronchi via adenosine A2 receptors. Eur J Pharmacol. 120:1986;179-185.
41. Ali S, Mustafa S J, Metzger W J. Adenosine-induced bronchoconstriction and contraction of airway smooth muscle from allergic rabbits with late-phase airway obstruction: evidence for an inducible adenosine A1 receptor. J Pharmacol Exp Ther. 268:1994;1328-1334.
42. Evans C M, Fryer A D, Jacoby D B, Gleich G J, Costello R W. Pretreatment with antibody to eosinophil major basic protein prevents hyperresponsiveness by protecting neuronal M2 muscarinic receptors in antigen-challenged guinea pigs. J Clin Invest. 100:1997;2254-2262.
43. Costello R W, Schofield B H, Kephart G M, Gleich G J, Jacoby D B, Fryer A D. Localization of eosinophils to airway nerves and effect on neuronal M2 muscarinic receptor function. Am J Physiol. 273:1997;L93-L103.
44. Fryer A D, Costello R W, Yost B L, Lobb R R, Tedder T F, Steeber D A, Bochner BS. Antibody to VLA-4 but not L-selectin protects neuronal M2 muscarinic receptor function in antigen challenged guinea-pig airways. J Clin Invest. 99:1997;2036-2044.
45. Jacoby D B, Gleich G J, Fryer A D. Human eosinophil major basic protein is an endogenous allosteric antagonist at the inhibitory muscarinic M2 receptor. J Clin Invest. 91:1993;1314-1318.
46. Maclagan J, Faulkner D. Effect of pirenzepine and gallamine on cardiac and pulmonary muscarinic receptors in the rabbit. Br J Pharmacol. 97:1989;506-512.
47. Matsumoto S, Nagayama T, Kanno T, Yamasaki M, Shimizu T. Evidence for the presence of function and the inhibitory M2 receptors in the rabbit airways and lungs. J Auton Nerve Syst. 53:1995;126-136.
48. Loenders B, Rampart M, Herman A G. Selective M3 muscarinic receptor antagonists inhibit smooth muscle contraction in rabbit trachea without increasing the release of acetylcholine. J Pharmacol Exp Ther. 263:1992;773-779.
49. Dorje F, Levey A I, Brann M R. Immunological detection of muscarinic receptor subtype proteins (m1-m5) in rabbit peripheral tissues. Mol Pharmacol. 40:1991;459-462.
50. Yasuda R P, Ciesla W, Flores L R, Wall SJ, Li M, Satkus S A, Weisstein J S, Spagnola B V, Wolfe B B. Development of antisera selective for m4 and m5 muscarinic cholinergic receptors: distribution of m4 and m5 receptors in rat brain. Mol Pharmacol. 43:1993;149-157.
51. Mak J C, Haddad E B, Buckley N J, Barnes P J. Visualization of muscarinic m4 mRNA and M4 receptor subtype in rabbit lung. Life Sci. 53:1993;1501-1508.
52. Lazareno S, Buckley NJ, Roberts F F. Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cells. Mol Pharmacol. 38:1990;805-815.
53. Haddad E B, Trifilieff A, Landry Y, Gies J P. Heterogeneity of guinea-pig lung muscarinic receptors revealed by [3H]4-DAMP-binding. Pulm Pharmacol. 6:1993;119-127.
54. Minette P J, Lammers J W J, Dixon C M S, McCusker M T, Barnes P J. A muscarinic agonist inhibits reflex bronchoconstriction in normal but not asthmatic subjects. J Appl Physiol. 67:1989;2461-2465.
55. 2receptors in subjects with mild bronchial hyperreactivity [abstract]. Eur Respir J. 12:1998;S10.