Facile substitution of N,N-dimethylanilines and phenols with trifluoroacetaldehyde ethyl hemiacetal

Synlett

Volumn , Issue 9, 1999, Pages 1403-1404

  Gong, Yuefa ^a   Kato, Katsuya ^a   Kimoto, Hiroshi ^a  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

Aromatic substitution; N,N dimethylaniline; Phenol; Trifluoroacetaldehyde ethyl hemiacetal; trifluoromethylbenzylic alcohol

Indexed keywords

ACETALDEHYDE; ALCOHOL; CARBONIC ACID; IMIDAZOLE DERIVATIVE; N,N DIMETHYLANILINE; PHENOL DERIVATIVE; POTASSIUM;

ARTICLE; CATALYSIS; CHEMICAL REACTION; GAS CHROMATOGRAPHY; LIQUID CRYSTAL; METHYLATION;

EID: 0032872848     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1999-2867     Document Type: Article

References (29)

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25. 2 to give the pure compound 3a.
26. 3 C% 54.77; H% 5.52, N% 6.39. Found C% 54.56, H% 5.46, N% 6.55.
27. 4. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (9:1 to 5:1 hexane: EtOAc), 6a (0.58g, 10%) and 4a (3.74g, 65%) being collected.
28. +, 55), 174 (18), 146 (40), 123 (95), 77 (100). HRMS. Calculated: 192.0398. Found: 192.0378.
29. +, 60), 151 (100). HRMS. Calculated: 220.0711. Found: 220.0711.