Tachykinins and in vivo gut motility

Digestive Diseases and Sciences

Volumn 44, Issue 8 SUPPL., 1999, Pages

  Sarna, Sushil K ^a,b  

^a CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Cyclical vomiting; Mass movements diarrhea; NK 1 receptors; NK 2 receptors; NK 3 receptors; Substance P; Vomiting

Indexed keywords

3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; NEUROKININ 1 RECEPTOR ANTAGONIST; TACHYKININ; TACHYKININ RECEPTOR;

ABDOMINAL CRAMP; CONFERENCE PAPER; DIARRHEA; INTESTINE CONTRACTION; INTESTINE MOTILITY; MOTOR ACTIVITY; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; VOMITING;

ADOLESCENT; ADULT; ANIMALS; CHILD; CHILD, PRESCHOOL; DIARRHEA; GASTROINTESTINAL MOTILITY; HUMANS; INFANT; PERIODICITY; RECEPTORS, TACHYKININ; SYNDROME; TACHYKININS; VOMITING;

EID: 0032872169     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (28)

1. Maggi CA, Patacchini R, Rovero P, Harnett KM: Tachykinin receptors and tachykinin receptor antagonists. J Auton Pharmacol 13:23-93, 1993
2. Nakanishi S: Mammalian tachykinin receptors. Annu Rev Neurosci 14:123-136, 1991
3. Giuliani S, Barbanti G, Turini D, Quartara L, Rovero P, Giachetti A, Maggi CA: NK2 tachykinin receptors and contraction of circular muscle of the human colon: Characterization of the NK2 receptor subtype. Eur J Pharmacol 203:365-370, 1991
4. Maggi CA, Patacchini R, Giachetti A, Meli A: Tachykinin receptors in the circular muscle of the guinea-pig ileum. Br J Pharmacol 101:996-1000, 1990
5. Hou J, Otterson MF, Sarna SK: Local effect of substance P on colonic motor activity in different experimental states. Am J Physiol 256:G997-G1004, 1989
6. Tsukamoto M, Sarna SK, Condon RE: A novel motility effect of tachykinins in normal and inflamed colon. Am J Physiol 272:G1607-G1614, 1997
7. Maggi CA, Patacchini R, Rovero P, Giachetti A: Tachykinin receptors and tachykinin receptor antagonist. J Auton Pharmacol 13:23-93, 1993
8. Bartho L, Holzer P: Search for a physiological role of substance P in gastrointestinal motility. Neuroscience 16:1-32, 1985
9. Guard S, Watson SP: Tachykinin receptor types: Classification and membrane signalling mechanisms. Neurochem Int 18:149-165, 1991
10. Szurszewski JH: A migrating electric complex of the canine small intestine. Am J Physiol 217:1757-1763, 1969
11. Sarna SK: Cyclic motor activity; migrating complex: 1985. Gastroenterology 89:894-913, 1985
12. Sarna SK, Otterson MF: Myoelectric and contractile activities. In Atlas of Gastrointestinal Motility in Health and Disease. MM Schuster (ed). Baltimore, Williams & Wilkins, 1993, pp 3-42
13. Sarna SK: Giant migrating contractions and their myoelectric correlates in the small intestine. Am J Physiol 253:G697-G705, 1987
14. Karaus M, Sarna SK: Giant migrating contractions during defecation in the dog colon. Gastroenterology 92:925-933, 1987
15. Quigley EMM, Phillips SF, Dent J: Distinctive patterns of interdigestive motility of the canine ileocolonic junction. Gastroenterology 87:836-844, 1984
16. Matsufuji H, Yokoyama J, Hirabayashi T, Watanabe S, Sakurai K: Cooperative roles of colon and anorectum during spontaneous defecation in conscious dogs. Dig Dis Sci 43:2042-2047, 1998
17. Bassotti G, Gaburri M, Imbimbo BP, Rossi L, Farroni F, Pelli MA, Morelli A: Colonic mass movements in idiopathic chronic constipation. Gut 29:1172-1179, 1988
18. Otterson MF, Leming S, Liu X, Mulder J: The role of peripheral NK1 receptors in radiation mediated changes in colonic motility. American Gastroenterological Association meeting, 1998 (abstract) (in press)
19. Tsukamoto M, Condon RE, Sarna SK: Tachykininergic regulation of motility in normal and inflamed ileum. 16th Int Symp Gastrointest Motil 1998 (abstract) (in press)
20. Grelot L, Dapzol J, Esteve E, Frugiere A, Bianchi AL, Sheldrick RL, Gardner CJ, Ward P: Potent inhibition of both the acute and delayed emetic responses to cisplatin in piglets treated with GR205171, a novel highly selective tachykinin NK1 receptor antagonist. Br J Pharmacol 124:1643-1650, 1998
21. Rudd JA, Jordan CC, Naylor RJ: The action of NK1 tachykinin receptor antagonist, CP 99,994, in antagonizing the acute and delayed emesis induced by cisplatin in the ferret. Br J Pharmacol 119:931-936, 1996
22. Gardner CJ, Armour DR, Beattie DT, Gale JD, Hawcock AB, Kilpatrick GJ, Twissell DJ, Ward P: GR205171: A novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity. Regul Pept 65:45-53, 1996
23. Hesketh P: Management of cisplatin-induced delayed emesis. Oncology 53(suppl 1):73-77, 1996
24. Singh L, Field MJ, Hughes J, Kuo BS, Suman-Chauhand N, Tuludhar BR, Wright DS, Naylor RJ: The tachykinin NK1 receptor antagonist PD 154075 blocks cisplatin-induced delayed emesis in the ferret. Fur J Pharmacol 321:209-216, 1997
25. Gardner CJ, Twissell DJ, Dale TJ, Gale JD, Jordan CC, Kilpatrick GJ, Bountra C, Ward P: The broad-spectrum anti-emetic activity of the novel non-peptide tachykinin NK1 receptor antagonist GR203040. Br J Pharmacol 116:3158-3163, 1995
26. Tattersall FD, Rycroft W, Hargreaves RJ, Hill RG: The tachykinin NK1 receptor antagonist CP-99,994 attenuates cisplatin induced emesis in the ferret. Eur J Pharmacol 250:R5-R6, 1993
27. Lang IM, Sarna SK, Condon RE: Gastrointestinal motor correlates of vomiting in the dog: quantification and characterization as an independent phenomenon. Gastroenterology 90:40-47, 1986
28. Otterson MF, Leming SC, Moulder JE: Central NK1 receptors mediate radiation induced emesis. Gastroenterology 112:A80, 1997 (abstract)