Deficits in vertical and torsional eye movements after uni- and bilateral muscimol inactivation of the interstitial nucleus of Cajal of the alert monkey

Experimental Brain Research

Volumn 119, Issue 4, 1998, Pages 436-452

  Helmchen, C ^a   Rambold, H ^a   Fuhry, L ^a   Buttner U ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Interstitial nucleus of Cajal; Neural integrator; Ocular counterroll; Torsional nystagmus; Vestibulo ocular reflex

Indexed keywords

MUSCIMOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EYE MOVEMENT; EYE POSITION; GAZE; MEDIAL LONGITUDINAL FASCICULUS; MESENCEPHALON; MONKEY; NONHUMAN; NYSTAGMUS; PRIORITY JOURNAL; SACCADIC EYE MOVEMENT; VESTIBULAR STIMULATION; VESTIBULOOCULAR REFLEX;

ANIMALS; CALIBRATION; ELECTRIC STIMULATION; EYE MOVEMENTS; GABA AGONISTS; MACACA MULATTA; MICROINJECTIONS; MUSCIMOL; NYSTAGMUS, PATHOLOGIC; OCULOMOTOR MUSCLES; PHOTIC STIMULATION; REFLEX, VESTIBULO-OCULAR; SACCADES; TEGMENTUM MESENCEPHALI; VESTIBULE;

EID: 0031945196     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002210050359     Document Type: Article

References (50)

1. Anderson JH (1981a) Ocular torsion in the cat after lesions of the interstitial nucleus of Cajal. Ann NY Acad Sci 374:865-871
2. Anderson JH (1981b) Behavior of the vertical canal VOR in normal and INC-lesioned cats. In: Fuchs AF, Becker W (eds) Progress in oculomotor research. (Developments in neuroscience, vol 12). Elsevier, Amsterdam, pp 395-401
3. Anderson JH, Precht W, Pappas C (1979) Changes in the vertical vestibulo-ocular reflex due to kainic acid lesions of the interstitial nucleus of Cajal. Neurosci Lett 14:259-264
4. Arnold DB, Robinson DA (1997) The oculomotor integrator: testing of a neural network model. Exp Brain Res 113:57-74
5. Bartl K, Siebold C, Glasauer S, Helmchen C, Büttner U (1996) A simplified calibration method for 3D eye movement recordings using search coils. Vision Res 36:997-1006
6. Bello S, Paige GD, Highstein SM (1991) The squirrel monkey vestibulo-ocular reflex and adaptive plasticity in yaw, pitch and roll. Exp Brain Res 87:57-66
7. Brandt T, Dieterich M (1993) Skew deviation with ocular torsion: a vestibular brainstem sign of topographic diagnostic value. Ann Neurol 33:528-534
8. Büttner U, Helmchen C, Büttner-Ennever JA (1995) The localizing value of nystagmus in brainstem disorders. Neuro-ophthalmology 15:283-290
9. Büttner-Ennever JA (1992) Patterns of connectivity in the vestibular nuclei. Ann NY Acad Sci 656:363-378
10. Cannon SC, Robinson DA (1987) Loss of the neural integrator of the oculomotor system from brain stem lesions in monkey. J Neurophysiol 57:1383-1409
11. Chimoto S, Iwamoto Y, Yoshida K (1992) Projections of vertical eye movement-related neurons in the interstitial nucleus of Cajal to the vestibular nucleus in the cat. Neurosci Res 15:293-298
12. Crawford JD, Vilis T (1992) Symmetry of oculomotor burst neuron coordinates about Listing's plane. J Neurophysiol 68:432-448
13. Crawford JD, Vilis T (1993) Modularity and parallel processing in the oculomotor integrator. Exp Brain Res 96:443-456
14. Crawford JD, Cadera W, Vilis T (1991) Generation of torsional and vertical eye position signals by the interstitial nucleus of Cajal. Science 252:1551-1553
15. Fukushima K (1987) The interstitial nucleus of Cajal and its role in the control of movements of head and eyes. Prog Neurobiol 29:107-192
16. Fukushima K, Fukushima J (1991) Involvement of the interstitial nucleus of Cajal in the midbrain reticular formation in position-related, tonic component of vertical eye movement and head posture. In: Berthoz A, Graf W, Vidai PP (eds) Head neck sensory motor system. Oxford University Press, New York, pp 330-345
17. Fukushima K, Fukushima J (1992) The interstitial nucleus of Cajal is involved in generating downward fast eye movements in alert cats. Neurosci Res 15:299-303
18. Fukushima K, Ohno M, Takahashi K, Kato M (1982) Location and vestibular responses of interstitial and midbrain reticular neurons that project to the vestibular nuclei in the cat. Exp Brain Res 45:303-312
19. Fukushima K, Takahashi K, Fukushima J, Ohno M, Kimura T, Kato M (1986) Effects of lesion of the interstitial nucleus of Cajal on vestibular nuclear neurons activated by vertical vestibular stimulation. Exp Brain Res 64:496-504
20. Fukushima K, Harada C, Fukushima J, Suzuki Y (1990) Spatial properties of vertical eye movement-related neurons in the region of the interstitial nucleus of Cajal in awake cats. Exp Brain Res 79:25-42
21. Fukushima K, Kaneko CR, Fuchs AF (1992a) The neuronal substrate of integration in the oculomotor system. Prog Neurobiol 39:609-639
22. Fukushima K, Ohashi T, Fukushima J, Kase M (1992b) Ocular torsion produced by unilateral chemical inactivation of the interstitial nucleus of Cajal in chronically labyrinthectomized cats. Neurosci Res 13:301-305
23. Fukushima K, Ohashi T, Fukushima J (1994) Effects of chemical deactivation of the interstitial nucleus of Cajal on the vertical vestibulo-collic reflex induced by pitch rotation in alert cats. Neurosci Res 20:281-286
24. Fukushima K, Ohashi T, Fukushima J, Kaneko CR (1995) Discharge characteristics of vestibular and saccade neurons in the rostral midbrain of alert cats. J Neurophysiol 73: 2129-2143
25. Graf W, Ezure K (1986) Morphology of vertical canal related second order vestibular neurons in the cat. Exp Brain Res 63:35-48
26. Halmagyi GM, Aw ST, Dehaene I, Curthoys IS, Todd MJ (1994) Jerk-waveform see-saw nystagmus due to a unilateral meso-di-encephalic lesion. Brain 117:789-803
27. Haslwanter T, Straumann D, Hess BJM, Henn V (1992) Static roll and pitch in the monkey: shift and rotation of Listing's plane. Vision Res 32:1341-1348
28. Helmchen C, Glasauer S, Bartl K, Büttner U (1996a) Contralesionally beating torsional nystagmus in a unilateral rostral midbrain lesion. Neurology 47:482-486
29. Helmchen C, Rambold H, Büttner U (1996b) Saccade-related burst neurons with torsional and vertical on-directions in the interstitial nucleus of Cajal of the alert monkey. Exp Brain Res 112:63-78
30. Helmchen C, Fuhry L, Rambold H, Büttner U (1997) The effect of mesencephalic lesions on 3-D eye movements. In: Fetter M, Haslwanter T, Misslich H, Tweed D (eds) Three-dimensional kinematics of eye-, head-, and limb movements. Harwood academic publishers, pp 237-242
31. Iwamoto Y, Kitama T, Yoshida K (1990) Vertical eye movement-related secondary vestibular neurons ascending in the medial longitudinal fasciculus in the cat. II. Direct connections with extra-ocular motoneurons. J Neurophysiol 63:918-935
32. Judge SJ, Richmond BJ, Chu FC (1980) Implantation of magnetic search coils for measurement of eye position: an improved method. Vision Res 20:535-538
33. King WM, Leigh RJ (1982) Physiology of vertical gaze. In: Lennerstrand EG, Zee DS, Keller EL (eds) Functional basis of ocular motility disorders. Pergamon Press, Oxford, pp 267-276
34. Kokkoroyannis T, Scudder CA, Balaban CD, Highstein SM, Moschovakis AK (1996) Anatomy and physiology of the primate interstitial nucleus of Cajal. I. Efferent projections. J Neurophysiol 75:725-739
35. Leigh RJ, Brandt T (1993) A reevaluation of the vestibulo-ocular reflex: new ideas of its purpose, porperties, neural substrate, and disorders. Neurology 43:1288-1295
36. Leigh RJ, Seidman SH, Grant MP, Hanna JP (1993) Loss of ipsidirectional quick phases of torsional nystagmus with a unilateral midbrain lesion. J Vestib Res 3:115-121
37. Le Taillanter M (1991) The interstitial nucleus of Cajal of the cat. II. Effects of kainic acid lesions on vertical optokinetic nystagmus and after-nystagmus. Arch Ital Biol 129:87-96
38. Markham CH (1989) Anatomy and physiology of otolith-controlled ocular counter-rolling. Acta Otolaryngol [Suppl] 468:263-266
39. McCrea RA, Strassman A, Highstein SM (1987) Anatomical and physiological characteristics of vestibular neurons mediating the vertical vestibulo-ocular reflex of the squirrel monkey. J Comp Neurol 264:571-594
40. Mettens P, Godaux E, Cheron G, Galiana HL (1994) Effect of muscimol microinjections into the prepositus hypoglossi and the medial vestibular nuclei on cat eye movements. J Neurophysiol 72:785-802
41. Moschovakis AK, Highstein SM (1994) The anatomy and physiology of primate neurons that control rapid eye movements. Annu Rev Neurosci 17:465-488
42. Partsalis AM, Highstein SM, Moschovakis AK (1994) Lesions of the posterior commissure disable the vertical neural integrator of the primate oculomotor system. J Neurophysiol 71:2582-2585
43. Riordan-Eva P, Faldon M, Büttner-Ennever JA, Gass A, Bronstein AM, Gresty MA (1996) Abnormalities of torsional fast phase eye movements in unilateral rostral midbrain disease. Neurology 47:201-207
44. Seidman SH, Leigh RJ, Tomsak RL, Grant MP, Dell'Osso LF (1995) Dynamic properties of the human vestibulo-ocular reflex during head rotations in roll. Vision Res 35:679-689
45. Straube A, Kurzan R, Büttner U (1991) Differential effects of bicuculline and muscimol microinjections into the vestibular nuclei on simian eye movements. Exp Brain Res 86:347-358
46. Suzuki Y, Büttner-Ennever JA, Straumann D, Hepp K, Hess BJM, Henn V (1995) Deficits in torsional and vertical rapid eye movements and shift of Listing's plane after uni- and bilateral lesions of the rostral interstitial nucleus of the medial longitudinal fasciculus (riMLF). Exp Brain Res 106:215-232
47. Tweed D, Cadera W, Vilis T (1990) Computing three dimensional eye position quaternions and eye velocity from search coil signals. Vision Res 30:97-110
48. Uchino Y, Sasaki M, Isu N, Hirai N, Imagawa M, Endo K, Graf W (1994) Second-order vestihular neuron morphology of the extra-MLF anterior canal pathway in the cat. Exp Brain Res 97:387-396
49. Vilis T, Hepp K, Schwarz U, Henn V (1989) On the generation of vertical and torsional rapid eye movements in the monkey. Exp Brain Res 77:1-11
50. Zee DS, Friendlich AR, Robinson DA (1974) The mechanism of downbeat nystagmus. Arch Neurol 30: 227-237