Lack of effect of clinical doses of cyclosporin A on erythrocyte Na+/K+-ATPase activity

Clinical Science

Volumn 97, Issue 3, 1999, Pages 283-290

  Ferrer Martínez, Andreu ^a   Felipe, Antonio ^a   Barceló, Pedro ^b   Casado, Francisco J ^a   Ballarín, José ^b   Pastor Anglada, Marçal ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b FUNDACIÓ PUIGVERT   (Spain)

Author keywords

Cyclosporin A; Erythrocyte; Kidney; Na+ K+ ATPase; Nephrotoxicity; Transplantation

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CELL ENZYME; CYCLOSPORIN A;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; ENZYME ACTIVITY; ENZYME INHIBITION; ERYTHROCYTE; HUMAN; HUMAN CELL; KIDNEY GRAFT; NEPHROTIC SYNDROME; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; SODIUM BLOOD LEVEL;

ADULT; CYCLOSPORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; NA(+)-K(+)-EXCHANGING ATPASE; NEPHROTIC SYNDROME; POSTOPERATIVE PERIOD;

EID: 0032869680     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS19990029     Document Type: Article

References (38)

1. Faulds, D., Goa, K. L. and Benfield, P. (1993) Cyclosporin: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders. Drugs 45, 953-1040
2. Borel, J. F. (1989) Pharmacology of cyclosporine (Sandimmune). Pharmacol. Rev. 41, 259-371
3. Schade, R. R., Guglielmi, D. H., Van Thiel, D. H. et al. (1983) Cholestasis in heart transplant recipients treated with cyclosporine. Transplant. Proc. 15, 2757-2760
4. Henny, F. C., Kleinbloesem, C. H., Moolenaar, A. J., Paul, L. C., Breimer, D. D. and Van Es, L. A. (1985) Pharmacokinetics and nephrotoxicity of cyclosporine in renal transplant recipients. Transplantation 40, 261-265
5. Kahan, B. D. (1989) Cyclosporine, N. Engl. J. Med. 321, 1725-1738
6. Porter, G. A. and Bennet, W. M. (1986) Chronic cyclosporine-associated nephrotoxicity. Transplant. Proc. 18, 204-207
7. Azer, S. A. and Stacey, N. H. (1991) Effect of cyclosporin A in vivo on taurocholate uptake by rat hepatocytes. Biochem. Pharmacol. 42, 2053-2057
8. Paller, M. S. and Murray, B. M. (1985) Renal dysfunction in animal models of cyclosporine toxicity. Transplant. Proc. 17, 155-159
9. Sumpio, B. E. (1988) Cyclosporine toxicity in the isolated perfused rat kidney. Transplant. Proc. 20, 712-716
10. Mihatsch, M. J., Thiel, G., Spichtin, H. P. et al. (1983) Morphological findings in kidney transplants after treatment with cyclosporine. Transplant, Proc. 15, 2821-2835
11. Moseley, R. H., Johnson, T. R. and Morrissette, J. M. (1990) Inhibition of bile acid transport by cyclosporine A in rat liver plasma membrane vesicles. J. Pharmacol. Exp. Ther. 253, 974-980
12. Liu, Y., Huang, L., Hoffman, T., Gosland, M. and Vore, M. (1996) MDR1 substrates/modulators protect against β-estradiol-17β-D-glucuronide cholcstasis in rat liver. Cancer Res. 56, 4992-4997
13. Shibata, N., Shimakawa, H., Ninouchi, T. and Yamaji, A. (1993) Erythrocyte uptake and protein binding of cyclosporin A (CyA) in human blood: factors affecting CyA concentration in erythrocytes. Biol. Pharm. Bull. 16, 702-707
14. Shibata, N., Minouchi, T., Yamaji, A. et al. (1995) Relationship between apparent total body clearance of cyclosporin A and its erythrocyte-to-plasma distribution ratio in renal transplant patients. Biol, Pharm. Bull. 18, 115-121
15. Suzuki, S., Oka, T., Ohkuma, S. and Kuriyama, K. (1987) Biochemical mechanisms underlying cyclosporine-induced nephrotoxicity: effect of concomitant administration of prednisolone. Transplantation 44, 363-368
16. +-ATPase activity by cyclosporin A. Kidney Int. 43, 246-251
17. +-ATPase of human erythrocytes by cyclosporine: possible role in hyperpotassemia in kidney transplant recipients. Transplant. Proc. 22, 1736-1739
18. Ferrer-Martínez, A., Felipe, A., Barceló, P., Casado, F. J., Ballarin, J. and Pastor-Anglada, M. (1996) Effects of cyclosporine A on Na,K-ATPasc expression in the renal epithelial cell line NBL-1. Kidney Int. 50, 1483-1489
19. - co-transporter in the renal epithelial cell line NBL-1 under osmotic stress. Biochem. J. 319, 337-342
20. Urien, S., Zini, R., Lemaire, M. and Tillement, J. P. (1990) Assessment of cyclosporine A Interactions with human plasma lipoproteins in vitro and in vivo in the rat. J. Pharmacol. Exp. Ther. 253, 305-309
21. +-D-glucose cotransporter. J. Biol. Chem. 265, 3270-3277
22. Agarwal, R. P., McPherson, R. A. and Threatte, G. A. (1986) Evidence of a cyclosporine-binding protein in human erythrocytes. Transplantation 42, 627-632
23. O'Leary, T. J., Ross, P. D., Lieber, M. R. and Levin, I. W. (1986) Effects of cyclosporine A on biomembranes: vibrational spectroscopic, calorimetric and hemolysis studies. Biophys. J. 49, 795-801
24. Yatscoff, R. W., Copeland, K. R. and Faraci, C. J. (1990) Abboth DTx monoclonal antibody assay evaluated for measuring cyclosporine in whole blood. Clin. Chem. 36, 1969-1973
25. + pump stoichiometry in adherent cells. Am. J. Physiol. 260, C1341-C1346
26. Adu, D., Turney, J. and McMaster, P. (1983) Hyperkalemia in cyclosporin-treated renal allograft recipients. Lancet ii, 370-371
27. Foley, R. J., Hamner, R. W. and Weinman, E. J. (1985) Serum potassium concentrations in cyclosporine- and azathioprine-treated renal transplant patients. Nephron 40, 280-285
28. Bantle, J. P., Ferris, T. F., Sutherland, D. E. R., Nath, K. A. and Najarian, J. S. (1985) Effects of cyclosporine on the renin-angiotensin-aldosterone system and potassium excretion of renal transplanted recipients. Arch. Intern. Med. 145, 505-508
29. Greiber, S., England, B. K., Price, S. R., Medford, R. M., Ebb, R. G. and Mitch, W. E. (1994) Na pump defects in chronic uremia cannot be attributed to changes in Na,K-ATPase mRNA or protein. Am. J. Physiol. 266, F536-F540
30. +-ATPase. Am. J. Physiol. 269, F673-F680
31. +-ATPase affects its conformation equilibrium. Proc. Natl. Acad, Sci. U.S.A. 93, 9132-9137
32. Batiuk, T. D., Pazderka, F., Enns, J., Decastro, L. and Halloran, P. E. (1995) Cyclosporine inhibition of calcincurin activity in human leukocytes in vivo is rapidly reversible. J. Clin. Invest. 96, 1254-1260
33. Batiuk, T. D., Urmson, J., Vincent, D., Yatscoff, R. W. and Halloran, P. F. (1996) Quantitating immunosuppression. Estimating the 50% inhibitory concentration for in vivu cyclosporine in mice. Transplantation 61, 1618-1624
34. Tumlin, J. A., Someren, J. T., Swanson, C. E. and Lea, J. P. (1995) Expression of calcineurin activity and alpha-subunit isoforms in specific segments of the rat nephron. Am. J. Physiol. 269, F558-F563
35. Batiuk, T. D., Pazderka, F., Enns, J., de Castro, L. and Halloran, P. F. (1996) Cyclosporine inhibition of leukocyte calcineurin is much less in whole blood than in culture medium. Transplantation 61, 158-161
36. Rokaw, M. D., West, M. E., Palevsky, P. M. and Johnson, J. P. (1996) FK-506 and rapamycin but not cyclosporin inhibit aldosterone-stimulated sodium transport in A6 cells. Am. J. Physiol. 271, C194-C202
37. Ziegler, K., Frimmer, M., Fritzsch, G. and Koepsell, H. (1988) Photoaffinity labelling of membrane proteins from rat liver and pig kidney with cyclosporinc diazirine. Transplantation 46, 15S-20S
38. Bang, H., Brune, K., Nager, C. and Feige, U. (1993) Interleukin-8 is a cyclosporin A binding protein. Experientia 49, 533-538