Growth hormone-releasing hormone and morphine attenuate growth hormone secretagogue-induced activation of the arcuate nucleus in the male rat

Neuroendocrinology

Volumn 70, Issue 2, 1999, Pages 101-106

  Bailey, Alex R T ^a,b   Honda, Kazufumi ^a   Smith, Roy G ^b   Leng, Gareth ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Arcuate nucleus; Growth hormone; Growth hormone secretagogues; Growth hormone releasing hormone; Opioids

Indexed keywords

GROWTH HORMONE; GROWTH HORMONE RECEPTOR; GROWTH HORMONE RELEASING FACTOR; GROWTH HORMONE SECRETAGOGUE; MORPHINE; PROTEIN C FOS; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARCUATE NUCLEUS; ARTICLE; CONTROLLED STUDY; GROWTH HORMONE RELEASE; HYPOPHYSIS; HYPOTHALAMUS; IMMUNOCYTOCHEMISTRY; MALE; NEGATIVE FEEDBACK; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ARCUATE NUCLEUS; ELECTROPHYSIOLOGY; FEEDBACK; GENE EXPRESSION; GENES, FOS; GROWTH HORMONE-RELEASING HORMONE; HORMONE ANTAGONISTS; HORMONES; IMMUNOHISTOCHEMISTRY; INDOLES; MALE; MORPHINE; NARCOTICS; OLIGOPEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; SPIRO COMPOUNDS;

EID: 0032868284     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000054464     Document Type: Article

References (30)

1. Tannenbaum GS, Ling N: The interrelationship of growth hormone (GH)-releasing factor and somatostatin in generation of the ultraradian rhythm of GH secretion. Endocrinology 1984;115:1952-1957.
2. Plotsky PM, Vale W: Patterns of growth hormone-releasing factor and somatostatin into the hypophysial circulation of the rat. Science 1985;230:461-463.
3. Pellegrini E, Bluet-Pajot MT, Mounier F, Bennet P, Kordon C, Epelbaum J: Central administration of a growth hormone (GH) receptor mRNA antisense increases GH pulsatility and decreases hypothalamic somatostatin expression in rats. J Neurosci 1996;16:8140-8148.
4. Katakami H, Downs TR, Frohman LA: Inhibitory effect of hypothalamic medial preoptic area somatostatin on growth hormone-releasing factor in the rat. Endocrinology 1988;123: 1103-1109.
5. Bowers CY, Momany FA, Reynolds GA, Hong A: On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology 1984;114:1537-1545.
6. Patchett AA, Nargund RP, Tata JR, Chen MH, Barakat KJ, Johnston DBR, Cheng K, Chan WWS, Butler B, Hickey G, Jacks T, Schleim K, Pong S-S, Chaung LYP, Chen HY, Frazier E, Leung KH, Chiu SHL, Smith RG: Design and biological activities of L-163, 191 (MK-0677) - a potent, orally-active growth-hormone secretagogue. Proc Natl Acad Sci USA 1995;92:7001-7005.
7. Dickson SL, Leng G, Robinson ICAF: Systemic administration of growth hormone-releasing peptide (GHRP-6) activates hypothalamic arcuate neurones. Neuroscience 1993;53: 303-306.
8. Bailey ART, Smith RG, Leng G: The non-peptide growth hormone secretagogue, MK-0677, activates hypothalamic arcuate nucleus neurones in vivo. J Neuroendocrinol 1988;10:111-118.
9. Dickson SL, Luckman SM: Induction of c-fos messenger ribonucleic acid in neuropeptide Y and growth hormone (GH)-releasing factor neurones in the rat arcuate nucleus following systemic injection of the GH secretagogue, GH-releasing peptide-6. Endocrinology 1997; 138:771-777.
10. Dickson SL, Viltart O, Bailey ART, Leng G: Attenuation of the growth hormone secretagogue induction of Fos protein in the rat arcuate nucleus by central somatostatin action. Neuroendocrinology 1997;66:188-194.
11. Zheng H, Bailey ART, Jiang M, Honda K, Chen HY, Trumbauer ME, Van der Ploeg LHT, Schaeffer JM, Leng G, Smith RG: Somatostatin receptor subtype-2 knockout mice are refractory to growth hormone negative feedback on arcuate neurones. Mol Endocrinol 1997;11:1709-1717.
12. Minami S, Kamegai J, Sugihara H, Hasegawa O, Wakabayashi I: Systemic injection of recombinant human growth hormone induces expression of the c-fos gene in the hypothalamic arcuate and periventricular nuclei in hypothysectomized rats. Endocrinology 1992;131: 247-253.
13. Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, Hamelin M, Hrenluk DL, Palyha OC, Anderson J, Paress PS, Diaz C, Chou M, Liu KK, McKee KK, Pong S-S, Chaung L-Y, Elbrecht A, Dashkevicz M, Heavens R, Rigby M, Sirinathsinghji DJS, Dean DC, Melillo DG, Patchett AA, Nargund R, Griffin PR, DeMartino JA, Gupta SK, Schaeffer JM, Smith RG, Van der Ploeg LHT: A pituitary gland and hypothalamic receptor that functions in growth hormone release. Science 1996;273:974-977.
14. Guan XM, Yu H, Palyha OC, McKee KK, Feighner SD, Sirinathsinghji DJS, Smith RG, Van der Ploeg LHT, Howard AD: Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Mol Brain Res 1997;48:23-29.
15. Willoughby JO, Medvedev A: Opioid receptor activation resets the hypothalamic clock generating growth hormone secretory bursts in the rat. J Endocrinol 1996;148:149-155.
16. Willoughby JO, Kappor R, Mackenzie L: Intrahypothalamic mu-, not delta- or kappa-opioid receptor activation causes growth hormone secretion. J Neuroendocrinol 1991;50:584-591.
17. Wimersma Greidanus TB, Grossman AB: Opioid regulation of pituitary function; in Ottoson D (ed): Progress in Sensory Physiology. Berlin, Springer, 1991, pp 1-64.
18. McCormick GF, Millard WJ, Badger TM, Bowers CY, Martin JB: Dose-response characteristics of various peptides with growth hormone-releasing activity in the unanesthetized male rat. Endocrinology 1985;117:97-105.
19. Daikoku S, Hisano S, Kawano H, Chikamori-Aoyama M, Kagotani Y, Zhan R, Chihara K: Ultrastructural evidence for neuronal regulation of growth hormone regulation. Neuroendocrinology 1988;47:405-415.
20. Lanzi R, Tannenbaum GS: Time course and mechanism of growth hormone's negative feedback effect on its own spontaneous release. 1992;130:780-788.
21. Burton KA, Steiner RA, Clifton DK: Double-label in situ hybridisation confirms that the GRF gene and the GH receptor gene are expressed in a subset of neurons in the arcuate nucleus (abstract No 1370). Proceedings of the 74th Annual Meeting of the Endocrine Society, 1992.
22. Chomczynski P, Downs TR, Frohman LA: Feedback regulation of growth hormone (GH)-releasing hormone gene expression in rat hypothalamus. Mol Endocrinol 1988;2:236-241.
23. Wood TL, Berelowitz M, Gelata MC, Roberts CT, LeRoith D, Millard WL, McKelvey JF: Hormonal regulation of rat hypothalamic neuropeptide mRNAs: Effect of hypophysectomy and hormone replacement on growth hormone-releasing factor, somatostatin and insulin-like growth factors. Neuroendocrinology 1991;53: 298-305.
24. Chan YY, Stenier RA, Clifton DK: Regulation of hypothalamic neuropeptide-Y neurons by growth hormone in the rat. Endocrinology 1996;137:1319-1325.
25. Kamegai J, Minami S, Sugihara H, Hasegawa O, Higuchi H, Wakabayashi I: Growth hormone receptor gene is expressed in neuropeptide-Y neurons in hypothalamic arcuate nucleus of rats. Endocrinology 1996;137:2109-2112.
26. Kamegai J, Minami S, Sugihara H, Higuchi H, Wakabayashi I: Growth hormone induces expression of the c-fos gene on hypothalamic neuropeptide-Y and somatostatin neurons in hypophysectomised rats. Endocrinology 1994; 135:2765-2771.
27. Chihara K, Minamitani N, Kaji H, Arimura A, Fulita T: Intraventricularly injected growth hormone stimulates somatostatin release into the portal blood. Endocrinology 1981;109: 2279-2281.
28. Minami S, Kamegai J, Hasegawa O, Sugihara H, Okada K, Wakabayashi I: Expression of growth hormone receptor gene in rat hypothalamus. J Neuroendocrinol 1993;5:691-696.
29. Minami S, Suzuki N, Sugihara H, Tamura H, Emoto N, Wakabayashi I: Microinjection of rat GH but not human IGF-1 into a defined area of the hypothalamus inhibits endogenous GH secretion in rats. J Endocrinol 1997;153:283-290.
30. Dickson SL, Leng G, Robinson IC: Electrical stimulation of the rat periventricular nucleus influences the activity of hypothalamic arcuate neurones. J Neuroendocrinol 1994;6:359-367.